2-Amino-3-carbethoxypyridine

2-Amino-3-ethoxycarbonyl pyridine is an important substance in chemistry. It has a wide range of uses and is widely used in the field of medicine and chemical industry.
First of all, medicine. Based on this, many drugs can be made. It has a special structure and can interact with molecules in the body of organisms. For example, the synthesis of some antibacterial drugs, by virtue of their chemical properties, can combine with key targets in bacteria, block their metabolism or growth, and achieve antibacterial effect. And in the development of anti-tumor drugs, it can also be used. After chemical modification, it can target tumor cells, interfere with tumor cell proliferation, differentiation and other processes, and provide a way for the creation of anti-cancer drugs.
And chemical industry. In organic synthesis, it is often used as a key intermediate. Because it contains amino and ethoxycarbonyl groups, it can participate in a variety of reactions. Such as condensation reaction with other compounds containing specific functional groups to build complex organic structures. This structure is very critical in the preparation of chemical products such as dyes and fragrances. When making some bright and stable dyes, 2-amino-3-ethoxycarbonyl pyridine is used to participate in the reaction, giving the dye a special structure, increasing its color fastness and color brightness. In fragrance synthesis, molecules with unique aroma structures can be constructed to add novel aroma to fragrances.
In short, 2-amino-3-ethoxycarbonyl pyridine has important uses in the pharmaceutical and chemical fields due to its special structure, and is an indispensable raw material for many Product Research & Development and Preparation.

To prepare 2-amino-3-ethoxycarbonyl pyridine, there are several common synthesis methods. First, 3-cyanopyridine can be started. First, 3-cyanopyridine is hydrolyzed with a suitable base, such as sodium hydroxide solution, at a suitable temperature and duration, to obtain 3-pyridinecarboxylic acid. In this step, the cyanyl group is hydrolyzed to a carboxyl group. Then, ethanol and concentrated sulfuric acid are used as esterification reagents, and the esterification reaction is carried out by heating to convert 3-pyridinecarboxylic acid into 3-ethoxycarbonyl pyridinecarboxylic acid. Finally, using strong reducing agents such as lithium aluminum hydride, in a low temperature and anhydrous environment, the carboxyl group is reduced to alcohol, and then a suitable amination reagent, such as ammonia gas and catalyst, is aminated to obtain 2-amino-3-ethoxycarbonyl pyridine.
Second, pyridine is used as the initial raw material. First, through halogenation reaction, halogen atoms are introduced at the second position of pyridine, such as bromine and pyridine, and under the catalysis of catalysts such as iron powder, 2-bromopyridine can be obtained. Then 2-bromopyridine and diethyl malonate undergo nucleophilic substitution reaction under the action of strong bases such as sodium ethanol to form diethyl pyridine-2-glycolonate. After that, hydrolysis and decarboxylation are performed to obtain 2-pyridyl ethyl acetate. Finally, by suitable amination means, such as ammonia water and suitable catalyst, it is aminated to obtain the target product 2-amino-3-ethoxycarbonyl pyridine.
There is also a method of using 2-hydroxy-3-ethoxycarbonyl pyridine as a raw material. 2-Amino-3-ethoxycarbonyl pyridine is obtained by reacting 2-hydroxy-3-ethoxycarbonyl pyridine with a suitable halogenating agent, such as phosphorus oxychloride. Then the halogenate is reacted with ammonia or a suitable amine source under a catalyst and suitable conditions for nucleophilic substitution to obtain 2-amino-3-ethoxycarbonyl pyridine. Each method has its own advantages and disadvantages, and it needs to be synthesized according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product.

2-Amino-3-ethoxycarbonyl pyridine is a kind of organic compound. Its physical properties are quite unique, let me tell you in detail.
Looking at its appearance, it is often white to white crystalline powder, delicate and uniform, like the snow at the beginning of winter, or shimmering under the light, pure and simple.
As for its melting point, it is in a specific temperature range. The definition of this temperature is crucial for the identification and purification of this substance. When heated to the melting point, this substance slowly melts from solid to liquid, just like ice and snow melting in the warm sun. This transformation process also follows specific physical laws. < Br >
In terms of solubility, it exhibits unique solubility properties in common organic solvents. In some organic solvents such as ethanol and acetone, it can have a certain solubility, just like fish entering water and gradually fusing. This solubility property lays an important foundation for its application in chemical synthesis, separation and purification, and preparation.
In addition, the density of 2-amino-3-ethoxycarbonyl pyridine is also an important characterization of its physical properties. The density value reflects the mass of its unit volume, which is like a gauge for measuring the compactness of a substance.
Its boiling point cannot be ignored either. When the temperature rises to the boiling point, the substance changes from liquid to gaseous state, and the force between molecules changes significantly. The value of this boiling point plays a crucial role in separation operations such as distillation, guiding the temperature control of the operation.
In summary, the physical properties of 2-amino-3-ethoxycarbonyl pyridine, such as appearance, melting point, solubility, density and boiling point, are interrelated and each shows its unique significance. It is an indispensable consideration in the research and application field of organic chemistry.

The price of 2-amino-3-ethoxycarbonyl pyridine in the market often varies for many reasons. The procurement of its raw materials, the simplicity of its preparation, and the balance of supply and demand are all important factors that affect the price.
If the raw materials are rare and difficult to find, or the procurement cost is high, the price of this material will also be high. As for the preparation method, if the steps are complicated, a lot of fine handling is required, and a lot of time and materials are consumed, the price will also rise.
Furthermore, the situation of market supply and demand also affects its price. If there are many people who want it, and there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price may fall.
In the previous works of "Tiangong Kaiwu", although this thing was not detailed, the reason is the same. The book talks about the production of various things, which involves raw materials, processes, supply and demand. The price of 2-amino-3-ethoxycarbonyl pyridine today also follows this path. To know its exact price, you should consult the merchants of chemical materials, or in the market of chemical trading, and carefully observe the market situation to obtain its recent fair price. Due to the change of times, the price is also changeable, so real-time information is the way to know its price.

2-Amino-3-ethoxycarbonyl pyridine, when storing and transporting, need to pay attention to many matters. This is an organic compound, the nature is very critical.
Bear the brunt, when storing, be sure to choose a cool, dry and well-ventilated place. Because it is afraid of moisture and heat, if placed in a high temperature and humid place, it may cause changes in properties or even deterioration. And it needs to be stored in isolation from oxidants, acids, alkalis, etc., because contact with it is easy to cause chemical reactions and damage its quality.
Furthermore, during transportation, do not slack. Make sure that the packaging is intact to prevent leakage. The means of transportation should be clean and dry to avoid mixing impurities. When handling, it should be handled with care, and do not load and unload brutally to prevent package damage. If it encounters hot weather during transportation, corresponding cooling measures must be taken to prevent excessive temperature from affecting its stability.
In addition, relevant regulations and standards must be strictly followed whether it is storage or transportation. Operators should be familiar with its characteristics and safety precautions, and have necessary protective equipment to prevent accidents from happening. In this way, 2-amino-3-ethoxycarbonyl pyridine is safe during storage and transportation.