2-amino-3-bromopyridine

2-Amino-3-bromopyridine is an important class of organic compounds. It has the following physical properties:
Under normal temperature, it is mostly white to light yellow crystalline powder, which is easy to identify and process.
When it comes to the melting point, it is about 124-128 ° C. As a key physical constant of the substance, the melting point plays a significant role in identification and purity determination. This temperature range indicates that under specific heating conditions, the substance will change from solid to liquid, reflecting the characteristics of intermolecular forces.
As for solubility, 2-amino-3-bromopyridine is slightly soluble in water. Water is a common solvent, and its slightly soluble properties suggest that the molecular polarity does not match well with water molecules. However, it is soluble in organic solvents such as ethanol and dichloromethane. Ethanol contains hydroxyl groups, and dichloromethane has a certain polarity, which can form appropriate intermolecular interactions with the compound, such as hydrogen bonds, van der Waals forces, etc., thereby promoting dissolution.
Although the exact value of its density is unknown, as an organic compound, it can be presumed to be similar to the density of common organic solids. The density is related to the relationship between mass and volume of substances, which is of great significance for storage, transportation and process design.
In air, 2-amino-3-bromopyridine is relatively stable, but it gradually changes with time, or due to factors such as light and humidity. Because it contains amino and bromine atoms, the amino group is alkaline to a certain extent, and the activity of bromine atoms is also high, or it participates in chemical reactions, resulting in gradual changes in its properties.
In addition, its odor is weak, not pungent and unpleasant, which is quite advantageous for operation and use environment creation.

2-Amino-3-bromopyridine is also an organic compound. Its chemical properties are unique and of great research value.
This compound contains amino and bromine atoms, which have a great influence on its chemical properties. Amino is an electron-supplying group, which is alkaline and can form salts with acids. Because nitrogen atoms have lone pairs of electrons, they can participate in nucleophilic reactions, such as reacting with halogenated hydrocarbons to form new carbon-nitrogen bonds.
And bromine atoms are electron-withdrawing groups, which reduce the electron cloud density of pyridine rings. Under suitable conditions, bromine atoms can undergo nucleophilic substitution reactions. When encountering nucleophilic reagents, bromine atoms can be replaced to form different derivatives.
In addition, the pyridine ring of 2-amino-3-bromo-pyridine also has its characteristics. Pyridine rings are aromatic and relatively stable, but they can also participate in the typical reactions of some aromatic compounds, such as electrophilic substitution reactions. However, due to the positioning effect of amino and bromine atoms, the reaction check point is different from that of ordinary pyridine.
Due to its special chemical properties, 2-amino-3-bromo-pyridine is widely used in drug synthesis, materials science and other fields, and is an important intermediate in organic synthesis.

2-Amino-3-bromopyridine is an important intermediate in organic synthesis. There are several methods for its common synthesis.
One is to use pyridine as the starting material. Shilling pyridine through nitration reaction to obtain nitropyridine. In this step, it is necessary to choose an appropriate nitrifying agent, such as the mixed acid of concentrated nitric acid and concentrated sulfuric acid, and control the reaction temperature, time and other conditions, so that the nitro is introduced at the appropriate position of the pyridine ring. After reducing the nitro group to an amino group, catalytic hydrogenation can be used, with palladium carbon as a catalyst, reacting at a suitable hydrogen pressure and temperature; chemical reduction can also be used, such as iron filings and hydrochloric acid as reducing agents, aminopyridine can be obtained through this step. Then the aminopyridine is reacted with a brominating reagent, such as liquid bromine in the presence of an appropriate solvent and catalyst, to achieve the substitution of bromine atoms in the amino ortho-position, and finally 2-amino-3-bromopyridine is obtained.
The second one uses 2-aminopyridine as the starting material. This compound can be prepared from the corresponding pyridine derivative through multi-step reaction. After obtaining 2-aminopyridine, it is directly reacted with the brominating reagent. However, due to the positioning effect of the amino group, the bromination reaction may require appropriate protection and deprotection of the amino group. The amino group is often protected by groups such as acetyl, and then brominated, brominated, and deprotected, so as to obtain the target product 2-aminopyridine.
The third or from other derivatives of pyridine, through multi-step functional group transformation. For example, other functional groups that are easy to convert are introduced first, and then the desired 2-aminopyridine structure is gradually constructed through substitution, oxidation, reduction and other reactions. Each method has its own advantages and disadvantages, and the synthesis needs to be carefully selected according to the availability of raw materials, the difficulty of reaction, the yield and cost.

2-Amino-3-bromopyridine is also a wonder, and it has its uses in various fields.
In the field of medicine, it is the key raw material for the synthesis of wonderful medicines. The unique structure of Gainpyridine, the nitrogen atom has a lone pair of electrons, which can interact with biological macromolecules. And the amino group and bromine atom can also be chemically reacted to introduce specific groups to make special drugs. Such as antibacterial agents, or anti-cancer drugs, 2-amino-3-bromopyridine may be the starting substance, and after multiple steps of delicate reactions, it will eventually become a cure and save people.
In the realm of pesticides, it also has a place. Based on it, highly effective insecticides and bactericides can be made. The chemical stability and biological activity of the pyridine ring make the synthetic pesticide effective on pests or pathogens, and the impact on the environment is controllable. Its bromine atom can enhance the lipid solubility of the molecule, which is conducive to penetrating the epidermis or cell wall of pests and pathogens, and the amino group can adjust the polarity and reactivity of the molecule, making the pesticide more targeted and active.
In the field of material chemistry, 2-amino-3-bromo-pyridine is also a useful material. In polymer synthesis, it can be used as a monomer or a crosslinking agent. The pyridine ring can participate in the polymerization reaction, build a special polymer structure, and endow the material with unique properties, such as good thermal stability, mechanical properties or electrical properties. And the amino and bromine atoms can be used as reaction check points to further modify the polymer to meet the needs of different applications, such as the preparation of optoelectronic materials, high-performance engineering plastics, etc.
In the field of catalysis, it may be a ligand that coordinates with metal ions to form a high-efficiency catalyst. The electronic effect and spatial structure of the pyridine ring can adjust the electron cloud density and three-dimensional environment of the metal center, thereby affecting the activity and selectivity of the catalytic reaction. The presence of amino and bromine atoms can finely regulate the properties of ligands, making catalysts suitable for a variety of chemical reactions, such as coupling reactions in organic synthesis.
From this perspective, although 2-amino-3-bromopyridine is small, it plays an important role in many fields such as medicine, pesticides, materials, catalysis, etc., contributing to the advancement of science and technology and the benefit of people's livelihood.

2-Amino-3-bromopyridine, the price of this product in the market depends on various factors, which is difficult to hide.
The first one to bear the brunt is its purity. If the purity is very high, near the extreme, and the impurities are minimal, the price will be high. Cover high-purity products, in many fine chemical processes, pharmaceutical research and development fields, are indispensable products. Its quality is high, and it can ensure the purity and efficiency of subsequent products. Therefore, if you ask for it, the price will also rise.
Furthermore, the state of market supply and demand has a deep impact on its price. If the demand for 2-amino-3-bromopyridine surges in many pharmaceutical companies and chemical workshops for a while, and the supply is difficult to respond to in time, showing a state of shortage, the price will rise like a rising tide. On the contrary, if the demand is weak and the supply is full, the price will decline to promote its circulation.
The difficulty of production also affects its price. If the method of preparing 2-amino-3-bromopyridine is cumbersome, requires multiple processes, and each step needs to be precisely controlled. It consumes many rare raw materials and a lot of manpower and material resources. The cost is high, and its price cannot be lower.
In addition, the availability and abundance of competing products in the market also depend on their price. If there are many similar alternatives and the price is good and easy to obtain, then 2-amino-3-bromopyridine is a competitive market, and the price may need to be reduced as appropriate.
Looking at the past market, the fluctuation of its price varies due to the changes of the above reasons. Therefore, in order to know the current inter-market price determination of 2-amino-3-bromopyridine, it is necessary to carefully observe the dynamics of the chemical raw material market and consult all suppliers in order to obtain a more accurate number to meet the needs of business.