2 Acetylpyridine
pyridine pyrrole pyrazine piperidine piperazine

2-acetylpyridine

    Specifications

    HS Code

    176944

    Chemical Formula C7H7NO
    Molar Mass 121.14 g/mol
    Appearance Colorless to light yellow liquid
    Boiling Point 203 - 204 °C
    Melting Point -15 °C
    Density 1.073 g/cm³
    Solubility In Water Slightly soluble
    Solubility In Organic Solvents Soluble in ethanol, ether, etc.
    Flash Point 85 °C
    Odor Characteristic odor

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    Frequently Asked Questions

    As a leading 2-acetylpyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of 2-acetylpyridine?
    2-Acetylpyridine is an organic compound. It has special chemical properties, which are described in detail by you.
    First of all, its physical properties, 2-acetylpyridine is a colorless to light yellow liquid at room temperature, with a unique odor. Its boiling point is quite high, about 220-222 ° C. Due to the existence of certain forces between molecules, more energy is required to make it boil. Its density is also characterized, about 1.0316g/cm ³. Compared with water, it can be separated according to density differences in mixed systems.
    When it comes to chemical properties, its molecules contain pyridine rings and acetyl groups, which give it various reactivity. The pyridine ring is aromatic and can undergo electrophilic substitution reaction. Because the nitrogen atom has lone pairs of electrons, the electron cloud density on the ring is uneven, and the substitution reaction mostly occurs at the β-position of the pyridine ring. If it is with halogenated hydrocarbons under appropriate conditions, electrophilic substitution can occur, and halogen atoms can be introduced into the pyridine ring.
    The presence of acetyl groups makes 2-acetylpyridine participate in many carbonyl-related reactions. It can be added to nucleophiles, such as with alcohols under acid catalysis, acetals or hemiacetals can be formed. In case of reducing agents, such as sodium borohydride, the carbonyl group of the acetyl group can be reduced to a hydroxyl group to obtain the corresponding alcohol compound. < Br >
    Furthermore, 2-acetylpyridine can coordinate with metal ions. The nitrogen atom of the pyridine ring can provide lone pairs of electrons to form coordination bonds with metal ions. This property is very useful in the field of catalysis. It can be used as a ligand to stabilize metal catalysts and change the activity and selectivity of catalysts.
    2-acetylpyridine has important applications in organic synthesis, medicinal chemistry, materials science and other fields due to its unique chemical properties. It can be used as a synthesis intermediate to produce various functional compounds.
    What are the applications of 2-acetylpyridine?
    2-Acetylpyridine is an organic compound that has many uses in many fields. In the field of medicine, it is often a key intermediate in the synthesis of drugs. Due to its unique structure, it can participate in a variety of chemical reactions and help build complex drug molecular structures. For example, when developing antibacterial and anti-inflammatory drugs, 2-acetylpyridine can be converted into compounds containing special pharmacoactive groups through specific reactions, thus exerting therapeutic effects.
    In the field of materials science, 2-acetylpyridine is also quite important. It can be used to prepare functional materials, such as some materials with special optical and electrical properties. By polymerizing or reacting with other compounds, the properties of materials can be adjusted to meet different application requirements, such as in optoelectronic devices, sensors, etc. < Br >
    In chemical production, it can participate in many organic synthesis reactions as a raw material for organic synthesis. It can be used to prepare fragrances and add unique aroma to products; it can also be used to synthesize dyes, giving them unique colors and properties to meet the needs of textile, printing and dyeing industries.
    In the field of analytical chemistry, 2-acetylpyridine can be used as an analytical reagent. With its selective reaction with specific substances, it can be used to detect, isolate and identify other compounds, providing an effective means for chemical analysis work.
    What is the preparation method of 2-acetylpyridine?
    2-Acetylpyridine is 2-acetylpyridine. There are several common methods for preparing 2-acetylpyridine.
    First, pyridine is used as a group to react with acetic anhydride under specific conditions. This reaction requires the assistance of suitable catalysts, such as anhydrous zinc chloride. In a reactor, add pyridine and acetic anhydride in a certain proportion, heat and maintain a certain temperature range, so that the two can fully react. The nitrogen atom of pyridine has lone pairs of electrons, and the carbonyl carbon in acetic anhydride has a certain positive electricity. The two interact and go through a complex reaction process to finally generate 2-acetylpyridine. In this process, the control of temperature is crucial. If it is too high, side reactions will increase, and if it is too low, the reaction rate will be slow, which needs to be precisely regulated.
    Second, 2-methylpyridine can also be used as raw material. 2-Acetylpyridine can be obtained by oxidation reaction. Suitable oxidizing agents, such as specific metal oxides or peroxides, are often used. In the reaction system, 2-methylpyridine and an appropriate amount of oxidizing agent are added. Under certain reaction conditions, the methyl group of 2-methylpyridine is oxidized to an acetyl group to obtain the target product. This reaction requires attention to the optimization of the amount of oxidizing agent and reaction conditions to ensure higher yield and purity.
    Furthermore, 2-acetylpyridine methanol is used as the starting material. 2-acetylpyridine can be prepared by oxidation reaction. Commonly used oxidants such as chromic acid, etc. In a suitable solvent, 2-pyridine methanol reacts with an oxidant, and the hydroxyl group is oxidized to a carbonyl group to form 2-acetylpyridine. During this reaction operation, attention should be paid to the process of the reaction and the separation and purification of the product to obtain pure 2-acetylpyridine.
    What are the physical properties of 2-acetylpyridine?
    2-Acetylpyridine is an organic compound with unique physical properties, so let me tell you one by one.
    The appearance of this substance is often a light yellow to amber liquid, with a certain transparency in appearance, and it exists stably in ordinary environments. Its unique smell emits a special aromatic smell, which is discernible.
    When it comes to the melting point, it is about -21 ° C. Under this low temperature, the substance can still maintain a liquid state. The boiling point is between 212-214 ° C. It needs to reach this temperature range before it can boil and transform into a gaseous state. Its density is about 1.0316g/cm ³, which is slightly heavier than water. If placed in one place with water, it will sink underwater.
    2 - acetylpyridine also has characteristics of solubility, soluble in many organic solvents, such as ethanol, ether, etc., and can be mutually soluble with it. In the field of organic synthesis, this property provides convenience for its participation in various reactions. However, its solubility in water is limited and only slightly soluble.
    In addition, the vapor pressure of the substance has a specific value at a specific temperature, which is related to its balance between the gas and liquid phases. Its refractive index is also an important physical parameter, about 1.5212, and the corresponding refraction phenomenon occurs when light passes through.
    In conclusion, the physical properties of 2-acetylpyridine play an important role in the research and application of organic chemistry, laying the foundation for its related reactions and uses.
    What is the market outlook for 2-acetylpyridine?
    2-Acetylpyridine is also a chemical substance. Looking at its market prospects, there are many reasons to argue.
    In terms of its use, this substance is quite useful in the field of pharmaceutical and chemical industry. When medicine is prepared, it can be a key intermediate. In today's world, the demand for medicine is constant, people are paying more and more attention to health matters, and pharmaceutical research and development is also becoming more and more refined. Therefore, drugs made with 2-acetylpyridine as an intermediate, if they are symptomatic and effective, will surely win the favor of the market, and their demand will also rise.
    In the chemical industry, 2-acetylpyridine can be used to synthesize special materials. Nowadays, technology is new, and the need for new materials is endless. Whether it is electronic materials, optical materials or other high-tech materials, all have their needs. If the developer can make good use of this material and produce materials with excellent performance, the market will be wide.
    However, changes in the market are not only beneficial, but also challenging. The production process may have technical thresholds. If the manufacturer fails to grasp the advanced process, it may be difficult to ensure the quality assurance of mass production, resulting in high cost and low output, which is at a disadvantage in the market competition. And there may be similar substitutes in the market. If the substitutes are cheap and high quality, they will also share their market share.
    But overall, with the advance of science and technology and changes in demand, if 2-acetylpyridine can be properly responded to in the R & D, production and other links, its market prospects are promising, or it can occupy a place in the pharmaceutical and chemical industry market and contribute to the development of the industry.