2-acetyl-5-bromopyridine

2-Acetyl-5-bromopyridine is an organic compound with unique chemical properties and a wide range of uses in the field of organic synthesis.
This compound contains a pyridine ring, which is aromatic and has certain stability and electron delocalization characteristics. The 5-position bromine atom is highly active. Due to the strong electronegativity of the bromine atom, it is partially positively charged with the carbon band connected to the pyridine ring, which is prone to nucleophilic substitution reactions. For example, when encountering nucleophiles, the bromine atom can be replaced to form a new carbon-heteroatomic bond, which lays the foundation for the construction of complex organic molecular structures.
The presence of the 2-position acetyl group adds carbonyl chemical properties to the compound. Carbonyl groups are polar and electrophilic, and can undergo many reactions, such as addition reactions with nucleophiles. Under specific conditions, they can be reduced to alcohol hydroxyl groups or condensed with compounds containing active hydrogen, which can be used to synthesize organic compounds with specific structures and functions.
In addition, 2-acetyl-5-bromopyridine can participate in metal catalytic coupling reactions due to the interaction of pyridine rings, bromine atoms and acetyl groups. Under suitable catalysts, ligands and reaction conditions, it can be coupled with other organic halides or olefins to achieve carbon-carbon bond formation, which is of great significance in the fields of drug synthesis and materials science. It can construct a molecular skeleton of bioactive drugs or prepare organic materials with special optoelectronic properties.
Due to its diverse chemical properties, 2-acetyl-5-bromopyridine plays an important role in organic synthesis chemistry, providing an effective way for the synthesis of novel and practical organic compounds.

2-Acetyl-5-bromopyridine is an important compound in organic synthesis, and its common synthesis methods are as follows.
First, 5-bromopyridine-2-carboxylic acid is used as the starting material. First, this acid is esterified with ethanol under the catalysis of concentrated sulfuric acid to generate 5-bromopyridine-2-carboxylic acid ethyl ester. This reaction needs to be controlled at a suitable temperature range, generally about 60-80 ° C, and refluxed for several hours to make the reaction fully proceed. Then, the ester is reduced by metal hydrides such as LiAlH to obtain 5-bromopyridin-2-methanol. The reduction reaction requires the slow addition of LiAlHin an anhydrous and oxygen-free environment at a low temperature such as about 0 ° C to ensure a smooth reaction. Finally, through Swern oxidation, 5-bromopyridin-2-methanol is oxidized to 2-acetyl-5-bromopyridine using oxalyl chloride, dimethyl sulfoxide and other reagents. This oxidation reaction requires the addition of oxalyl chloride and dimethyl sulfoxide at a low temperature such as -78 ° C. After a period of reaction, alcohol is added for oxidation.
Second, 2-methyl-5-bromopyridine is used as the starting material. Acetylation reagents such as acetyl chloride or acetic anhydride can be used to carry out the Friedel-Crafts acylation reaction under the catalysis of Lewis acids such as AlCl or FeCl. This reaction is carried out under anhydrous conditions, generally at room temperature to about 50 ° C, and is monitored and adjusted according to the reaction process. It should be noted that the amount of Lewis acid and the reaction conditions will affect the selectivity and yield of the reaction.
Third, it is synthesized by a coupling reaction catalyzed by transition metals. For example, 5-bromopyridine derivatives are coupled with acetyl borate esters or acetyl halides in the presence of transition metal catalysts and ligands such as palladium or nickel. This kind of reaction requires the selection of suitable bases and solvents, common bases such as potassium carbonate, sodium carbonate, etc., solvents such as dioxane, N, N-dimethylformamide, etc. The reaction temperature is generally 80-120 ℃, and the reaction system needs to be strictly dehydrated and deoxygenated to improve the reaction efficiency and product purity.

2-Acetyl-5-bromopyridine is one of the organic compounds. It has applications in many fields, as detailed below.
In the field of pharmaceutical chemistry, this compound is often used as a key intermediate. Due to its unique structure, it can add functional groups through chemical reactions, and then build complex drug molecular structures. Taking the development of anti-cancer drugs as an example, based on the characteristics of its pyridine ring, acetyl group and bromine atoms, it can be modified to combine with specific targets of cancer cells to inhibit the growth and proliferation of cancer cells.
In the field of materials science, 2-acetyl-5-bromopyridine also has important uses. Or used in the preparation of organic optoelectronic materials, the pyridine ring gives it good electron transport properties, and the acetyl group and bromine atoms can adjust the energy level structure and optical properties of the material. In this way, by polymerization or compounding, Light Emitting Diode materials, solar cell materials, etc. with excellent performance can be prepared, and the photoelectric conversion efficiency can be improved.
In the field of pesticide chemistry, it can be used as a starting material for the synthesis of new pesticides. With its chemical activity, it can synthesize pesticides with high toxic effect on pests or inhibitory effect on plant pathogens. Due to its special structure, it may reduce the harm to the environment and improve the selectivity and safety of pesticides.
In addition, in organic synthetic chemistry, 2-acetyl-5-bromopyridine, as an important building block, participates in the construction of many complex organic molecules. By selecting suitable reaction conditions and reagents, chemists use the nucleophilic substitution reaction of bromine atoms and the related conversion reaction of acetyl groups to expand the structural diversity of molecules and provide a rich material basis for the development of organic synthetic chemistry.

2-Acetyl-5-bromopyridine is also an organic compound. To know its market price, it is quite complicated, due to the interaction of many factors.
First, the source of raw materials and cost are of great importance. The preparation of this compound requires specific raw materials. If the raw materials are scarce, or the origin changes, or the market supply and demand imbalance can cause fluctuations in the price of raw materials, which in turn affects the price of 2-acetyl-5-bromopyridine. If the raw materials are collected from remote places, the transportation is difficult, the cost will increase, and the price of the product will also rise.
Second, the simplicity and advanced degree of the production process are also key. Sophisticated and efficient production processes can improve output efficiency, reduce energy consumption and waste, and reduce costs, making prices more affordable. However, if the process is outdated, inefficient, and costly, the market price will naturally be high.
Third, the amount of market demand determines the price. If an industry has strong demand for 2-acetyl-5-bromopyridine, such as pharmacy for specific drug synthesis, the demand increases sharply and the supply is temporarily difficult, the price will rise; conversely, the demand is low and the supply is excessive, and the price will be under pressure.
Fourth, the competitive situation should not be underestimated. If there are many manufacturers in the market and the competition is fierce, each manufacturer will compete for a share, or the price will be used as a weapon, which will prompt the price to decline; if only a few manufacturers monopolize production, the price will be easily controlled at a high level.
Fifth, the macroeconomic environment also has an impact. Currency exchange rate fluctuations, inflation or deflation can change production costs and market purchasing power, thus affecting the market price of 2-acetyl-5-bromopyridine.
In summary, the market price of 2-acetyl-5-bromopyridine changes dynamically due to many factors such as raw materials, processes, demand, competition and economic environment, and it is difficult to say a word to hide its specific price. To know the exact price, it is necessary to inspect the market in real time and consult industry merchants or professional institutions in order to obtain a more accurate figure.

2-Acetyl-5-bromopyridine is an organic compound. Regarding its safety and toxicity, I will explain in detail.
The toxicity of this compound may exist in many aspects. From the chemical structure analysis, the bromine atom is connected to the pyridine ring, which has a certain biological activity and can affect the biochemical process of the organism. Bromine atoms can also enhance the lipophilicity of the compound, making it easier to penetrate the biofilm, and then have an effect on cells. The presence of acetyl groups may affect the metabolic pathway of the compound, or trigger specific chemical reactions in the organism.
As for safety, special attention should be paid when handling this compound. It may be irritating, and if it touches the skin, it can cause redness and pain. Once in contact with the eyes, the harm is more serious, or the eye tissue is damaged, affecting vision. If it inhales dust or vapor, or irritates the respiratory tract, it can cause symptoms such as cough and breathing difficulties. After swallowing, it may cause corrosion and irritation to the digestive tract, endangering health.
Also be cautious when storing. Keep in a cool, well-ventilated place, away from sources of fire and oxidants to prevent dangerous chemical reactions. When operating, wear appropriate protective equipment, such as protective gloves, goggles and protective clothing, to reduce the risk of exposure.
In summary, 2-acetyl-5-bromopyridine is toxic and potentially dangerous, and strict safety procedures must be followed when using and storing it to ensure the safety of personnel and the environment from contamination.