2-Acetyl-4-chloropyridine

2-Acetyl-4-chloropyridine is one of the organic compounds. Its physical properties are quite characteristic and it has been applied in many fields.
Looking at its appearance, under normal temperature and pressure, it is mostly white to light yellow crystalline powder. This morphology can help to identify and distinguish it from many similar compounds.
As for the melting point, it is about 65-69 ° C. The melting point is the temperature limit at which a substance changes from a solid state to a liquid state. This melting point range of the compound provides an important basis for controlling temperature conditions and implementing separation or purification processes in specific experiments and industrial operations.
Its solubility is also a key property. In organic solvents such as ethanol and acetone, it exhibits good solubility. Ethanol and acetone are common organic solvents with moderate polarity. 2-Acetyl-4-chloropyridine can dissolve in both, which shows that its molecular structure and solvent molecules can form suitable interactions, such as hydrogen bonds, van der Waals forces, etc., so that it can be uniformly dispersed in the solvent system. However, its solubility in water is poor. In water, solvents with extremely strong polarity have weak interactions with the molecules of the compound, making it difficult to overcome their intermolecular forces to achieve dissolution.
2-Acetyl-4-chloropyridine has low volatility. Volatility is related to the tendency of a substance to change from a liquid or solid state to a gaseous state. The low volatility of this compound indicates that it is relatively stable at room temperature and does not easily escape into the air. This property is convenient for storage and use to ensure its quality and safety.
Furthermore, the density of this compound is about 1.28 g/cm ³. Density, the mass of a substance per unit volume. This value reflects its molecular compactness and also affects its distribution and behavior in specific systems such as mixed solutions.
In summary, the physical properties of 2-acetyl-4-chloropyridine, such as appearance, melting point, solubility, volatility, and density, are interrelated and together determine their performance in various chemical processes and practical applications. This provides a solid foundation for researchers and industrial producers to effectively utilize this substance.

2-Acetyl-4-chloropyridine is also an organic compound. Its synthesis method has been studied by chemists in the past.
One method starts with 4-chloropyridine and can be obtained by acylation. First, 4-chloropyridine and acetic anhydride are co-placed in the reaction kettle, and an appropriate amount of catalyst is added, such as anhydrous aluminum trichloride. At an appropriate temperature, usually about 60 to 80 degrees Celsius, stir. Among them, anhydrous aluminum trichloride catalyzes that the acyl group of acetic anhydride is connected to the carbon atom adjacent to the nitrogen atom of 4-chloropyridine, and the reaction gradually becomes complete after several days. After cooling, it is extracted with a suitable solvent such as dichloromethane, and then washed, dried, and distilled to obtain pure 2-acetyl-4-chloropyridine.
Another method is to use 2-methyl-4-chloropyridine as a raw material. First, an oxidizing agent, such as potassium permanganate, oxidizes its methyl group to a carboxyl group in an alkaline environment to obtain 4-chloropyridine-2-carboxylic acid. The carboxylic acid is then reacted with sulfoxide chloride to convert the carboxyl group to an acyl chloride. Then reacted with a suitable reducing agent, such as lithium aluminum hydride, at low temperature to reduce the acyl chloride to an aldehyde group. Finally, 2-acetyl-4-chloropyridine can also be obtained by using an oxidizing agent, such as manganese dioxide and aldehyde oxide as acetyl group. However, this process step is slightly complicated, and fine temperature control and reaction conditions are required to ensure the smooth reaction of each step.
Another pyridine derivative is used as the starting material and obtained by multi-step reaction such as halogenation and acylation. The pyridine derivative is first halogenated, chlorine atoms are introduced at a suitable position, and then the acetyl group is introduced by acylation reaction. These methods have their own advantages and disadvantages, depending on the availability of raw materials, the cost and the difficulty of reaction.

2-Acetyl-4-chloropyridine is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry. Due to its unique chemical structure, it can participate in a variety of chemical reactions and help synthesize various bioactive compounds, making great contributions to the creation of new drugs.
In the field of pesticide chemistry, 2-acetyl-4-chloropyridine also has important uses. It can be converted into pesticide ingredients with insecticidal, bactericidal or herbicidal effects through a specific reaction path, providing assistance for agricultural pest control and weed control to ensure the healthy growth and harvest of crops.
Furthermore, in the field of materials science, this compound may be used as a basic raw material for the construction of functional materials. By polymerizing or reacting with other substances, materials with special properties, such as optoelectronic materials, are formed, which play a potential role in cutting-edge technologies such as electronics and optics. All of these demonstrate the important value of 2-acetyl-4-chloropyridine in many fields, and are indispensable elements for the development of chemical synthesis and related industries.

2-Acetyl-4-chloropyridine is also an organic compound. When storing and transporting, many matters should be paid attention to.
First words storage, this compound should be stored in a cool, dry and well ventilated place. Cover its properties or be affected by temperature and humidity, if placed in a warm and humid place, it may cause deterioration. Keep away from fires and heat sources to prevent fires. Because of its flammability, it is easy to cause danger in case of open flames and hot topics. And it should be stored separately from oxidants, acids, bases, etc., and cannot be mixed. It may react with various chemicals or chemically, which will damage its quality or even cause danger. The storage place should be equipped with suitable materials to contain leaks to prevent accidents.
As for transportation, it is necessary to ensure that the container is well sealed to prevent its leakage and volatilization. During transportation, the speed of the vehicle should not be too fast, and do not brake suddenly to avoid damage to the container due to vibration and collision. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment. Drivers and escorts must be familiar with its characteristics and emergency measures. During transportation, they should be strictly guarded and not leave without authorization.
In short, in the storage and transportation of 2-acetyl-4-chloropyridine, it is necessary to follow relevant specifications and requirements, and operate carefully to ensure safety and avoid dangerous accidents.

There is a question today, what is the market price range of 2-acetyl-4-chloropyridine. This is a product in the field of fine chemicals, and its price varies according to quality, purity, supply and demand, and transaction scale.
In the past, in small-scale transactions, if the purity is ordinary, the price per gram is about tens of yuan. However, if the purity is high, reaching the scientific research level, the price per gram may reach more than 100 yuan.
If the transaction scale is in the kilogram level, due to the scale effect, the price per kilogram may be in the thousands. If its demand is strong and supply is scarce, its price will rise; if supply exceeds demand, the price will decline.
In addition, the prices charged by different suppliers are also different. Well-known large factories, because of their good quality control, high brand reputation, or high pricing; while small factories, although the price or low, but the quality also needs to be carefully inspected.
All in all, in order to determine its exact price range, it is necessary to carefully study the current market supply and demand, quality standards and the specific situation of suppliers in order to obtain it.