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What are the main uses of 2,6-dimethyl-4-hydroxy-3-nitropyridine?
2% 2C6-dimethyl-4-nitro-3-pyridone is an important organic compound that is widely used in the field of organic synthesis. Its main uses are as follows:
First, as a key intermediate in organic synthesis. It can be converted into compounds with more complex structures by various chemical reactions, such as nucleophilic substitution, reduction, etc. For example, its nitro group can be reduced to an amino group, which can further participate in various coupling reactions and be used to construct nitrogen-containing heterocyclic compounds. It is of great significance in pharmaceutical chemistry, materials science and other fields. In drug synthesis, it can be used as a basis for modifying molecular structures with specific biological activities.
Second, it is widely used in the field of medicine. Due to the structure of pyridinone and the characteristics of its substituents, some derivatives synthesized based on 2% 2C6-dimethyl-4-nitro-3-pyridinone exhibit certain biological activities, such as antibacterial, anti-inflammatory, anti-tumor, etc. After structural modification and optimization, new drugs may be developed.
Third, it also has potential uses in the field of materials science. It can be used as a structural unit for constructing functional materials, such as designing and synthesizing organic materials with specific optical and electrical properties. The electron cloud distribution and functional group characteristics in its molecular structure may endow the material with unique photoelectric properties, and may play a role in the research and development of organic Light Emitting Diodes, solar cells and other materials.
What are the synthesis methods of 2,6-dimethyl-4-hydroxy-3-nitropyridine?
To prepare 2,6-dimethyl-4-nitro-3-chloropyridine, there are various methods. First, it can be obtained from suitable pyridine derivatives through nitration, chlorination, methylation, etc. First, take the pyridine derivative, use a nitrifying agent, and under appropriate conditions, make the nitro group enter the specific position of the pyridine ring to obtain the nitropyridine derivative. Then add a chlorinating agent to make the chlorine atom connect to the target check point to obtain the nitrochloropyridine derivative. Finally, a methylating agent is applied to make the methyl group attached to the pyridine ring, and then form 2,6-dimethyl-4-nitro-3-chloropyridine.
Second, another synthesis path can be designed. Starting with chloropyridine, the chlorine atom is connected to the pyridine ring through methylation reaction, and then introduced into the methylpyridine ring to obtain chloromethylpyridine. Then a nitrating agent is used to act on it, and the nitro group is introduced into the appropriate position under a suitable environment to obtain 2,6-dimethyl-4-nitro-3-chloropyridine.
Third, it can also start from methyl-containing pyridine. Chlorination first, so that the chlorine atom is connected to the pyridine ring, and then nitrification, so that the nitro group is connected to the designated site, and the final synthesis target product is 2,6-dimethyl-4-nitro-3-chloropyridine. Each method requires attention to the control of reaction conditions, such as temperature, pressure, and the proportion of reactants, in order to promote the reaction and improve the purity and yield of the product.
What are the physical properties of 2,6-dimethyl-4-hydroxy-3-nitropyridine?
2% 2C6-dimethyl-4-nitro-3-chloropyridine is an organic compound with special physical properties. The following are detailed by Jun:
Its appearance is either solid or crystalline. Due to the strong intermolecular force and orderly molecular arrangement of the compound, it is mostly solid under normal conditions. This form is easy to store and transport, not easy to volatilize and dissipate, and has good stability.
Melting point is one of its important physical properties. Different compounds have different melting points due to differences in structure and intermolecular force. The melting point of 2% 2C6-dimethyl-4-nitro-3-chloropyridine or in a specific temperature range can help to identify the compound and is also of great significance for its purification and separation. By measuring the melting point, its purity can be judged. If the melting point is consistent with the standard value and the melting range is narrow, the purity is high; conversely, if the melting range is wide and the melting point deviates from the standard value, it contains more impurities.
The boiling point is also a key property. The boiling point reflects the energy required for the compound to change from liquid to gaseous state. The boiling point of 2% 2C6-dimethyl-4-nitro-3-chloropyridine is related to the intermolecular force, and the strong force is higher. Understanding the boiling point can control the temperature during the separation process such as distillation and fractionation, and achieve effective separation from other compounds.
The solubility cannot be ignored either. Its solubility varies in different solvents, but it is poor in polar solvents. Due to the weak polarity of the compound, it follows the principle of "similar miscibility". Polar solutes are easily soluble in polar solvents, and non-polar solutes are easily soluble in non-polar solvents. Solubility or relatively good in organic solvents. This is crucial for selecting a suitable solvent for reaction and crystallization in organic synthesis. Suitable solvents can improve the reaction yield and product purity.
In addition, the density of the compound also has specific values. Density is related to molecular mass and molecular stacking mode, and is of great significance to the study of its behavior in solution and the physical processes involved. For example, in extraction, delamination and other operations, density differences can achieve material separation.
In summary, the physical properties of 2% 2C6-dimethyl-4-nitro-3-chloropyridine, such as appearance, melting point, boiling point, solubility, density, etc., have a profound impact on its identification, separation, purification and application in organic synthesis. It is an important task for chemists to study and master these properties.
What are the chemical properties of 2,6-dimethyl-4-hydroxy-3-nitropyridine?
2% 2C6-dimethyl-4-nitro-3-pyridyl formaldehyde, which is an organic compound with unique chemical properties.
It has an aldehyde group and has typical properties of aldehyde. At room temperature, it can react with weak oxidants, such as silver ammonia solution, and the aldehyde group is oxidized to a carboxyl group to generate corresponding carboxylate, silver elemental substance, ammonia gas, and water. This reaction can be used to identify the existence of aldehyde groups. Co-heating with the new copper hydroxide suspension can produce brick-red precipitation, and the aldehyde group is converted into a carboxyl group, which is used to test aldehyde substances.
Because it contains nitro groups, it has certain oxidation properties. Nitrogen in the nitro group is in a higher valence state. Under certain conditions, electrons can be reduced. For example, under suitable reducing agents and reaction conditions, nitro groups can be gradually reduced to amino groups.
The methyl group of this compound is affected by the pyridine ring and other substituents, and its hydrogen atom activity will change. Under appropriate conditions, hydrogen on the methyl group can be substituted. For example, when it is illuminated or in the presence of a catalyst, it can be substituted with halogen elementals, and halogen atoms replace methyl hydrogen atoms.
In addition, the presence of pyridine rings gives it some special properties. Pyridine rings are alkaline to a certain extent, and lone pairs of electrons on nitrogen atoms can accept protons. Under the catalysis of acid or base, this compound can undergo a variety of reactions, such as the condensation reaction of aldehyde groups under basic conditions, etc. These reaction characteristics have important applications in the field of organic synthesis.
What is the price range of 2,6-dimethyl-4-hydroxy-3-nitropyridine in the market?
There are two substances today, called 2,6-dimethyl-4-nitro-3-chloropyridine. This is a chemical substance, and the price in the market cannot be determined in a single word. Its price often changes for many reasons, such as the difficulty of making it, the amount of demand, and the supply and demand of the market.
If it is easy to make this substance, and there are few applicants and many suppliers in the market, the price may be inexpensive. However, if it is difficult to make it, the materials used are expensive, and there are many applicants, and the supply is insufficient, the price will be high.
In the past, the price of this substance was between hundreds and thousands of yuan per kilogram. However, the market is impermanent, and the price is also impermanent. If you want to know the exact price, you can get a near-real price by consulting the chemical industry, the store selling this agent, or the price information of visiting the market. This is the normal situation of the market, and the price moves with the trend, which is difficult to predict.