2,6-Dimethyl-3-nitropyridine

2% 2C6-dimethyl-3-nitropyridine, this substance is colorless to light yellow liquid, has a special odor, and has a certain volatility. Its melting point is about -20 ° C, boiling point is between 215-217 ° C, density is about 1.12g/cm ³, stable at room temperature and pressure.
However, it is also dangerous. This substance is flammable and has the risk of explosion in case of open flame or hot topic. And toxic. If accidentally inhaled, ingested or absorbed through the skin, it may cause damage to the human body, damage or involve the nervous system, respiratory system, etc. When operating, extra caution is required. It must be operated in a well-ventilated environment and strictly in accordance with safety procedures. Necessary protective measures should also be taken, such as wearing protective glasses, gloves and gas masks.
In addition, 2% 2C6-dimethyl-3-nitropyridine, as an important intermediate in organic synthesis, is widely used in medicine, pesticides, dyes and other fields. It can be synthesized by pyridine and specific reagents through nitrification reaction, methylation reaction and other steps.

2% 2C6-dimethyl-3-nitropyridine is an organic compound with the following chemical properties:
1. ** Basic **: The pyridine ring nitrogen atom has unshared electron pairs, has a certain alkalinity, and can react with acids to form salts. If reacted with hydrochloric acid, the corresponding pyridine hydrochloride is formed. This property makes it stable in acidic environments, and can be separated and purified by means of salt properties.
2. ** Nucleophilic Substitution Reaction **: Nitro is a strong electron-absorbing group, which reduces the electron cloud density of the pyridine ring, especially the nitro o-ortho and para-position. The fourth position of 2,6-dimethyl-3-nitropyridine is affected by nitro groups, the electron cloud density is low, and it is vulnerable to attack by nucleophilic reagents, resulting in nucleophilic substitution reactions. Nucleophilic reagents such as sodium alcohols and amines can replace atoms or groups at specific positions on the pyridine ring to form new organic compounds, which is an important reaction path for organic synthesis.
3. ** Reduction Reaction **: Nitro groups can be reduced. Commonly used reducing agents include iron/hydrochloric acid, hydrogen/catalyst (such as palladium carbon), etc. Using hydrogen/palladium carbon as a reducing agent, the nitro group is reduced to an amino group to obtain 2,6-dimethyl-3-aminopyridine. This product is widely used in the field of drug synthesis and organic synthesis, and can be used as an intermediate to synthesize more complex compounds.
4. ** Oxidation reaction **: The pyridine ring is relatively stable, but it can be oxidized under specific conditions when exposed to strong oxidants. Under the action of appropriate oxidants (such as potassium permanganate), side chain methyl groups may be oxidized to carboxyl groups to form carboxyl-containing pyridine derivatives, introducing new functional groups for organic synthesis and expanding their reactivity and application range.

The common synthesis method of 2% 2C6-dimethyl-3-nitropyridine is not directly recorded in Tiangong Kaiwu, but in the ancient classical Chinese style, the synthesis method can be described as follows:
To obtain 2,6-dimethyl-3-nitropyridine, first take pyridine as the base, pyridine has the structure of nitrogen heterocyclic ring, the properties are different, and it is the foundation of synthesis. In an appropriate reactor, put an appropriate amount of pyridine, and use alcohol as the solvent, such as ethanol, to create a mild reaction environment.
Gradually add methylating reagents, such as iodomethane, to it, and carefully control the temperature. By water bath, the temperature should be maintained between 30 and 40 degrees Celsius. Iodomethane interacts with pyridine, and after nucleophilic substitution, the methyl group is gradually connected to the 2nd and 6th positions of the pyridine ring, and then becomes 2,6-dimethyl pyridine.
Then, the reaction of nitrification is carried out. Move 2,6-dimethyl pyridine to another clean reactor, mix concentrated sulfuric acid with concentrated nitric acid to form a mixed acid, and slowly drop it into the kettle. This process requires special attention to temperature control, and cool it in an ice bath so that the temperature does not exceed 10 degrees Celsius to prevent side reactions. Nitric acid is catalyzed by concentrated sulfuric acid to dissociate nitroyl positive ions, which have strong electrophilicity and attack the third position of 2,6-dimethyl-3-nitropyridine. After a series of electron rearrangements, 2,6-dimethyl-3-nitropyridine is finally obtained.
After the reaction is completed, the product is separated by distillation according to the different boiling points of each substance. After recrystallization, the product is purified with a suitable solvent, such as ethyl acetate, to obtain pure 2,6-dimethyl-3-nitropyridine.

2% 2C6-dimethyl-3-nitropyridine is useful in various fields.
In the field of medicine, it can be a key intermediate for the synthesis of drugs. For example, in the preparation of some antibacterial drugs, this compound can undergo a series of chemical reactions to introduce specific functional groups and shape the structure of drug molecules to obtain expected pharmacological activity. Because of its properties of the pyridine ring and the methyl and nitro groups attached to it, it can endow the drug with a specific spatial configuration and electronic effects, affecting the ability of the drug to bind to the target, so it is often useful in the development and synthesis of antibacterial drugs.
In the field of pesticides, it also plays an important role. It can be used as a raw material for the synthesis of new pesticides. By chemical modification, compounds with insecticidal, bactericidal or herbicidal activities can be derived. Pyridine structures often interfere with the physiological processes of pests or pathogens, or affect their nervous system, or destroy their cell metabolism, achieving the purpose of controlling pests and diseases, assisting agricultural production, and improving crop yield and quality.
In the field of materials science, 2% 2C6-dimethyl-3-nitropyridine can participate in the synthesis of functional materials. For example, polymerize with other organic monomers to form polymer materials with special photoelectric properties. Due to the fact that the nitro group in the structure can adjust the electron cloud distribution of the material, and the methyl group affects the solubility and thermal stability of the material, the obtained material may be used in organic Light Emitting Diodes, solar cells and other optoelectronic devices, showing unique optical and electrical properties, and contributing to the development of materials science.

I have heard your inquiry about the market price of 2,6-dimethyl-3-nitropyridine. However, the price of this product often changes for many reasons, and it is difficult to hide it in one word.
First, the supply and demand of the market is the key to the price. If there are many people who need it, but the supply is small, the price will increase; conversely, if the supply exceeds the demand, the price will decrease. Second, the cost of production is also the main factor of the price. The price of raw materials, labor costs, equipment consumption, etc., are all related to cost. If the cost is high, the price is also high; if the cost is reduced, the price may be reduced. Third, the competition in the market also has an impact. If there are many companies and the competition is fierce, the price may be lowered to attract customers; if there are few companies and they have the potential to monopolize, the price may be controllable and high.
In addition, changes in policies, changes in the current situation, or fluctuations in prices. Therefore, if you want to know the exact price, you should carefully examine the actual situation of the city, consult the industry, and consult the market newspapers, so that you can obtain a more accurate price. At this moment, it is difficult for me to give you a definite figure. I hope you can observe it yourself according to the above method.