2 6 Dimethoxypyridine
pyridine pyrrole pyrazine piperidine piperazine

2,6-dimethoxypyridine

    Specifications

    HS Code

    300138

    Name 2,6 - dimethoxypyridine
    Molecular Formula C7H9NO2
    Molecular Weight 139.15
    Appearance Colorless to light yellow liquid or solid
    Boiling Point 211 - 213 °C
    Melting Point 19 - 21 °C
    Density 1.103 g/cm³
    Flash Point 86 °C
    Solubility In Water Slightly soluble
    Odor Characteristic odor
    Pka 3.45 (approximate value in water for pyridinium ion)

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    General Information
    Where to Buy 2,6-dimethoxypyridine in China?
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    Frequently Asked Questions

    As a leading 2,6-dimethoxypyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2,6-dimethoxypyridine?
    2% 2C6-dimethoxypyridine has a wide range of main uses. This substance is a key raw material and intermediate in the field of organic synthesis.
    Looking at the scope of organic synthesis, 2% 2C6-dimethoxypyridine can be used as an extremely important building block when building the molecular structure of many complex organic compounds. For example, in the process of synthesizing natural products or drug molecules with specific biological activities, it can participate in various chemical reactions, such as nucleophilic substitution reactions, oxidation reactions, reduction reactions, etc., by virtue of its unique chemical structure, thereby helping to achieve the precise construction of target compounds.
    In the field of medicinal chemistry, 2% 2C6-dimethoxypyridine is used in many drug development projects. Because its structure can be chemically modified to meet the needs of different drug targets, it provides rich possibilities for the development of new drugs. For example, in the synthesis of some anti-cancer drugs and anti-infective drugs, its shadow can be found, which plays a crucial role in enhancing drug activity and improving pharmacokinetic properties.
    In the field of materials science, 2% 2C6-dimethoxypyridine also has outstanding performance. When preparing some functional polymer materials, it can be introduced into the main chain or side chain of the polymer to endow the material with good solubility, thermal stability, and specific optical and electrical properties. For example, when preparing optoelectronic functional materials, its unique electronic structure can be used to optimize the charge transport performance of the material, thereby improving the application efficiency of the material in optoelectronic devices.
    In summary, 2% 2C6-dimethoxypyridine occupies a pivotal position in many aspects such as chemical research and industrial production due to its important uses in organic synthesis, medicinal chemistry, and materials science.
    What are the physical properties of 2,6-dimethoxypyridine?
    2% 2C6 -dimethoxypyridine is an organic compound. Its physical properties are quite unique, let me tell you in detail.
    Looking at its properties, under room temperature and pressure, it is mostly colorless to light yellow liquid, with a clear and transparent texture, like a clear spring, without impurities visible to the naked eye. Its smell is also unique, emitting a special aroma. Although this aroma is not rich and pungent, it is also clearly recognizable, leaving a unique imprint on the sense of smell.
    Talking about the melting point, the melting point of this compound is low, about -40 ° C. Just like the ice and snow that are easy to melt under the warm sun in winter, the temperature rises slightly, and it quietly changes from solid to liquid. The boiling point is relatively high, about 170-172 ℃. When it is heated and the temperature gradually rises to the boiling point, it sublimates from liquid to gaseous like a phoenix.
    Again, the density of 2% 2C6-dimethoxypyridine is slightly higher than that of water, about 0.996g/cm3. Like a stable stone, it will slowly sink when thrown into water. Its solubility cannot be ignored, and it can be soluble in common organic solvents, such as ethanol and ether. It is like a fish entering water and fuses with organic solvents. However, the solubility in water is relatively small, and the two seem to be distinct and difficult to completely blend.
    In addition, the vapor pressure of 2% 2C6-dimethoxypyridine also has its characteristics. Under normal temperature conditions, the vapor pressure is low, indicating that its volatility is relatively weak and it is not easy to dissipate quickly into the air like light smoke. This physical property makes it relatively stable during storage and use, reducing losses and risks caused by volatilization.
    Is the chemical property of 2,6-dimethoxypyridine stable?
    2% 2C6-dimethoxypyridine, is this substance stable?
    To determine whether this substance is stable or not, it is necessary to investigate its molecular structure and reaction characteristics in detail. For 2% 2C6-dimethoxypyridine, the 2nd and 6th positions of the pyridine ring are replaced by methoxy groups. The pyridine ring has aromatic properties, the electron cloud distribution is uniform, and the structure is relatively stable. The methoxy group, as the power supply group, can increase the electron cloud density of the pyridine ring.
    The stability of the physical properties also involves the reaction conditions. Under normal temperature and pressure, if there is no strong oxidant, strong acid, strong base and other extreme reagents, it can be relatively stable. The aromatic system and the electronic effect of the substituent of the Gain pyridine ring can resist the weak influence of the outside world in general environment.
    But in case of high temperature and strong oxidizing agent, the aromaticity of the pyridine ring may be destroyed. If it is co-heated with the mixed acid of concentrated nitric acid and concentrated sulfuric acid, or causes the substitution reaction on the ring, the aromatic structure is damaged and the stability is lost. In addition, in case of active metal-organic reagents, such as Grignard reagents, because pyridine nitrogen has lone pair electrons, it can complex with metal reagents, causing the reaction of the pyridine ring and impairing its stability.
    In summary, the physical properties of 2% 2C6-dimethoxy pyridine are still stable under conventional conditions, but the stability is easily affected by special reaction conditions and reagents.
    What are the synthesis methods of 2,6-dimethoxypyridine?
    There are several common methods for the synthesis of 2% 2C6-diethoxybenzaldehyde:
    One is to use phenol as the starting material. Phenol is first reacted with haloethane under basic conditions. This is a nucleophilic substitution reaction. The oxygen atom of the phenolic hydroxyl group is nucleophilic and can attack the carbon atom of the haloethane to form ethoxybenzene. The ethoxybenzene is then acylated by Fu-g, and anhydrous aluminum trichloride is used as a catalyst to react with ethylene chloride to introduce an acyl group into the benzene ring, thereby generating 2-ethoxy-6-chloroformylacetophenone. After hydrolysis, decarboxylation and other steps, 2% 2C6-diethoxy benzaldehyde can be obtained. This route step is slightly complicated, but the raw materials are easy to obtain, the reaction conditions are relatively mild, and it is quite commonly used in laboratory synthesis.
    The second is resorcinol as the starting material. Resorcinol reacts with haloethane to form 2% 2C6-diethoxy phenol. Then, through the Wilsmeier-Hacker reaction, N, N-dimethylformamide (DMF) and phosphorus oxychloride are used as reagents to introduce formyl groups at the ortho-position of phenolic hydroxyl groups. This reaction cleverly uses the active intermediate formed by DMF and phosphorus oxychloride to attack the benzene ring and efficiently generate the target product 2% 2C6-diethoxybenzaldehyde. This method has short steps and considerable yields, which is quite advantageous for industrial production or large-scale preparation.
    The third is to use the Grignard reagent method. Halogenated acetophenone is used as raw material to prepare Grignard reagent, and then reacts with ethyl orthoformate to obtain 2% 2C6-diethoxybenzaldehyde after hydrolysis. This approach requires strict anhydrous and anaerobic conditions, and requires high requirements for reaction equipment and operation. However, its selectivity is good. If the conditions are properly controlled, high purity products can be obtained.
    What is the price range of 2,6-dimethoxypyridine in the market?
    There are two things today, called 2,6-diethoxybenzoyl. What is the price in the market? Let me tell you.
    This 2,6-diethoxybenzoyl is quite useful in the field of chemical industry. Its price is not the same, and it often varies depending on the quality of the product, the amount, and the supply and demand of the market. If it is of high quality and pure, the price may be slightly higher; if the quality is inferior and miscellaneous, the price is slightly lower.
    Looking at the market conditions, when the quantity is small, the price per gram may be between tens of dollars and hundreds of dollars. If the purchase quantity is huge, such as in kilograms, the price per kilogram may be around thousands to thousands of dollars. However, this is not a fixed number, the market conditions are ever-changing, and it is unpredictable.
    Or when the supply exceeds demand in the market, the price will tend to decline. In order to sell their goods quickly, merchants often reduce profits in order to sell. On the contrary, if the demand is too much, the goods are scarce and there are many people in need, and the price will skyrocket.
    And the difference in origin and the change of seasons are also related to the price. If it is shipped from a distance, the freight will be imposed, and the price will be high; if it is produced locally, or due to the convenience of the location, the price will be slightly lower. During the season, the abundance of raw materials and the increase or decrease in labor costs can cause price fluctuations. < Br >
    In order to determine the price of 2,6-diethoxybenzoyl, it is necessary to carefully check the market conditions and compare the prices of various companies to understand the approximation.