2 6 Dimethoxypyridine 3 Boronic Acid
pyridine pyrrole pyrazine piperidine piperazine

2,6-Dimethoxypyridine-3-boronic acid

    Specifications

    HS Code

    100410

    Chemical Formula C7H10BNO4
    Molar Mass 181.97 g/mol
    Appearance White to off - white solid
    Solubility In Water Moderate solubility in polar solvents
    Pka Value Related to its boronic acid group, around 8 - 9
    Melting Point Typically in the range of 160 - 170 °C
    Density Estimated density around 1.3 - 1.4 g/cm³
    Stability Stable under normal conditions, sensitive to strong acids and bases
    Reactivity Reactive towards electrophiles, used in cross - coupling reactions

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    General Information
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    Frequently Asked Questions

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    What are the chemical properties of 2,6-dimethoxypyridine-3-boronic acid?
    2% 2C6-diethoxyacetophenone-3-carboxylic acid, which is an organic compound with unique chemical properties. It is white to light yellow crystalline powder and exhibits chemical activity under specific conditions.
    From the perspective of reactivity, the carboxyl group of the compound is acidic and can be neutralized with bases. In case of alkali substances such as sodium hydroxide, the hydrogen atom in the carboxyl group will combine with hydroxide ions to form water, which itself becomes the corresponding carboxylate. This reaction is commonly used in acid-base neutralization steps in organic synthesis for the preparation of carboxylate derivatives.
    At the same time, the ethoxy group of the 2% 2C6-diethoxyacetophenone part can participate in nucleophilic substitution reactions under suitable conditions. In the presence of nucleophiles, ethoxy groups may be replaced to form new organic compound structures. This property provides the possibility for the construction of more complex organic molecules, which have important applications in organic synthesis in the fields of medicinal chemistry and materials science.
    Furthermore, carbonyl (C = O) is also an important reaction check point for this compound. Carbonyl groups have a certain polarity, and carbon atoms are partially positive and vulnerable to nucleophiles. For example, in some reduction reactions, carbonyl groups can be reduced to alcohol hydroxyl groups, which can significantly change the chemical properties and functions of the compound.
    In terms of stability, the compound is relatively stable at room temperature and pressure without special chemical environment. However, when exposed to high temperatures, strong oxidants or specific catalysts, decomposition or other complex chemical reactions may occur. During storage and use, appropriate conditions should be selected according to their chemical properties to prevent deterioration or dangerous reactions.
    What are the main uses of 2,6-dimethoxypyridine-3-boronic acid?
    2% 2C6-diethoxyacetophenone-3-carboxylic acid, this is an organic compound. Its main uses are as follows:
    First, in the field of drug synthesis, it can be called a key intermediate. Taking the preparation of a specific type of analgesic drug as an example, with the help of a series of chemical transformations, this compound can be integrated into the molecular structure of the drug, thereby giving the drug the biological activity and pharmacological properties required to play a role in relieving pain.
    Second, in the field of materials science, it can be used to synthesize polymer materials with unique properties. Through a carefully designed polymerization reaction, it is introduced into the polymer chain as a structural unit, so that the prepared material has special optical, electrical or mechanical properties, providing a basis for the research and development of new materials. Third, it is an extremely important research object for organic synthetic chemistry. Chemists use it as a starting material to develop novel organic synthesis methods by exploring different reaction conditions and paths, expanding the knowledge boundaries and technical means of organic chemistry, and promoting the continuous progress and development of organic synthetic chemistry.
    What are the synthesis methods of 2,6-dimethoxypyridine-3-boronic acid?
    To prepare 2,6-diethoxyacetophenone-3-carboxylic acid, the following ancient methods can be used.
    First, acetophenone derivatives are used as starting materials. First, acetophenone is applied to a suitable solvent and interacts with a base to generate the corresponding enolate. Subsequently, ethoxylation reagents, such as a combination of halogenated ethane and sodium alcohol, are added after nucleophilic substitution, and ethoxy groups can be introduced into the 2,6 position of the benzene ring to obtain 2,6-diethoxyacetophenone. Then, with suitable carboxylation reagents, such as carbon dioxide and strong bases, under specific conditions, 2,6-diethoxyacetophenone is applied to the 3 position to introduce carboxyl groups. This is the conventional route for preparing the target product.
    Second, you can also start from aromatic compounds. Select suitable aromatic hydrocarbons, and introduce ethoxy-containing acyl groups through Friedel-Crafts acylation reaction to build the basic structure of 2,6-diethoxy acetophenone. This reaction requires Lewis acid, such as anhydrous aluminum trichloride as a catalyst, to be carried out in a suitable temperature and solvent. After that, as in the previous method, carboxylation steps, carboxyl groups are introduced at 3 positions.
    Furthermore, the method of gradually constructing carbon chains can be considered. First prepare ethoxy-containing phenyl ring intermediates, and then react with carboxyl-containing precursors to gradually increase the carbon chain and build the target molecule. For example, ethoxy-containing phenylboronic acid is first synthesized, and a suitable halogenated acrylate is coupled with Suzuki to form a carbon-carbon bond, and then hydrolyzed to obtain the target 2,6-diethoxy acetophenone-3-carboxylic acid.
    Preparation of this compound, each method has its own advantages and disadvantages, and it is necessary to carefully select the appropriate synthesis route according to the actual availability of raw materials, the ease of control of reaction conditions, and the purity requirements of the product.
    What is the market price of 2,6-dimethoxypyridine-3-boronic acid?
    At present, the price of 2,6-dimethoxypyridine-3-boronic acid in the market often varies due to many factors. It is related to the source of materials, the precision of the process, the balance of demand and supply, and also involves the state of the market.
    If the material is wide and easy to obtain, the process is simple and efficient, and the supply exceeds the demand, the price will level or drop. However, if the source is thin, it is difficult to make, and the demand is more and less, the price will rise.
    Looking at the cities, the price often fluctuates between the number of gold per gram and tens of gold. In large factories, the quantity is large and the quality is high, and the price may be stable and suitable; in small workshops, the quantity is small and the quality is uneven, and the price may be variable.
    Also, differences in regions and differences in taxes also make prices variable. Prosperous cities have prosperous supply and demand, and prices may be high; remote places have difficulty in circulation, and prices may also be different. Therefore, if you want to know the exact price, you must carefully observe the time and city, and compare the reports of various families to obtain the actual price.
    What are the precautions for storing and transporting 2,6-dimethoxypyridine-3-boronic acid?
    2% 2C6-dimethoxyacetophenone-3-sulfonic acid is a rare chemical raw material. During storage and transportation, many matters need to be carefully paid attention to.
    Bear the brunt, and the control of temperature and humidity is the key. This material prefers a dry and cool environment. If it is exposed to high temperature and high humidity, it may cause changes in its properties or even cause chemical reactions. For example, in midsummer, it is necessary to use air conditioners and dehumidification equipment to maintain the storage environment temperature at around 20 degrees Celsius and humidity within 50% to prevent its quality from being damaged.
    Furthermore, the storage place should be kept away from fire sources, heat sources and oxidants. Because of its flammability, it is flammable in case of open flames, hot topics, contact with oxidants, or react violently, just like dry firewood in case of fire, so fireworks are strictly prohibited in the warehouse, and the distance between it and the oxidant should not be less than 3 meters.
    During transportation, the packaging must be solid and reliable. Choose suitable packaging materials, such as special plastic drums or iron drums lined with special materials, to prevent bumps and collisions from causing package damage and material leakage. When loading and unloading, it should also be handled with care to prevent brutal operation.
    In addition, this substance may be toxic and corrosive. Operators must be equipped with protective equipment, such as gas masks, acid and alkali-resistant gloves, protective work clothes, etc., to prevent human contact and injury. Transportation vehicles also need to be equipped with emergency treatment equipment and tools, such as fire extinguishers, adsorption materials, etc., for emergencies.
    Storage and transportation of 2% 2C6-dimethoxyacetophenone-3-sulfonic acid, all links must be rigorous. If there is a slight mistake, it may cause a disaster and cannot be ignored.