2,6-Dihydroxy-3-cyano-4-(trifluoromethyl)pyridine

2% 2C6-difluoryl-3-alkyl-4- (trifluoromethyl) pyridine, which has a wide range of uses. In the field of medicine, it is a key pharmaceutical intermediate. The structure of Geinpyridine has good biological activity and pharmacokinetic properties. By modifying and modifying the structure of the compound, new drugs with specific pharmacological activities can be created. For example, the synthesis of some antibacterial and anti-inflammatory drugs often uses it as a starting material to build complex drug molecular structures through multi-step reactions, so as to accurately act on disease targets and exert therapeutic effects.
In the field of pesticides, it also occupies an important position. As pesticide intermediates, high-efficiency, low-toxicity and environmentally friendly pesticide varieties can be synthesized. Pyridine pesticides often have excellent insecticidal, bactericidal and herbicidal activities, which can effectively control crop diseases and insect pests, and improve crop yield and quality. For example, some pyridine pesticides can interfere with the normal function of the nervous system of insects, causing paralysis and death, and are less toxic to mammals, which is conducive to ecological and environmental protection.
In the field of materials science, 2% 2C6-difluoro-3-alkyl-4- (trifluoromethyl) pyridine also shows unique value. It can be used to prepare polymer materials with excellent properties, such as fluoropolymers. The introduction of fluorine atoms can significantly improve the chemical stability, thermal stability and surface properties of materials. Fluoropolymers are often used in the manufacture of high-performance coatings, plastics, etc., and are widely used in high-end fields such as aerospace, electronics and appliances, providing key support for the development of related industries.

To prepare 2,6-difluoro-3-alkyl-4- (trifluoromethyl) pyridine, there are three methods.
One is the halogenated aromatic hydrocarbon nucleophilic substitution method. Using halogenated pyridine as the substrate, react with fluorine-containing nucleophilic reagents under appropriate conditions. For example, the halogenated pyridine with high halogen atom activity is selected. In an organic solvent, under the action of a base and a catalyst, it meets the fluoride nucleophilic reagent, and the halogen atom is replaced by a fluorine group. In this process, the properties of the solvent, the strength of the base, and the choice of the catalyst are all key. A good solvent needs to have good solubility to the substrate and the reagent, the base needs to be able to capture the protons of the nucleophilic reagent, and the catalyst accelerates the reaction and increases the amount of product.
The second is the method of building a pyridine ring. Take suitable fluorine-containing and alkyl-containing, trifluoromethyl-containing small molecules as raw materials and react to form a pyridine ring through cyclization. For example, fluorine-containing β-dicarbonyl compounds and nitrogen-containing reagents are cyclized under acidic or alkaline conditions. Acids or bases catalyze the condensation of molecules to build a pyridine skeleton. This approach has a variety of raw materials, and the reaction conditions vary from raw material to raw material. Reaction conditions, such as temperature, pH value, etc., need to be carefully regulated to ensure that the
The third is the functional group conversion method. The compound containing the pyridine ring is first prepared, and then the required fluoro group, alkyl group and trifluoromethyl group are introduced through a series of functional group conversion. If pyridine is used as the starting material, the halogen atom is first introduced by halogenation, and then the nucleophilic substitution of the halogen atom is changed to a fluoro group; the alkyl group and trifluoromethyl group can be introduced by alkylation and trifluoromethylation. There are many steps in this process, and attention should be paid to the selectivity and yield of each step, and the separation and purification of the intermediate product is also important to ensure the purity and yield of the final product.

2% 2C6-difluoryl-3-alkyl-4- (trifluoromethyl) pyridine This substance has unique and diverse properties. Its physical properties, at room temperature, are mostly liquid, occasionally solid, or transparent as water, or slightly yellowish, depending on its purity and structure.
Looking at its boiling point, it is slightly different from ordinary pyridine derivatives due to intermolecular forces. The addition of alkyl and fluoryl groups makes the intermolecular van der Waals force easier. The boiling point is often lower than that of the same family without fluorine, but higher than that of simple hydrocarbons. If it is common sense, its boiling point may be around a hundred degrees, depending on the length and branching of the specific alkyl group.
As for the melting point, the introduction of fluorine atoms makes the lattice arrangement change. Fluorine has strong electronegativity, which increases the polarity of molecules. The intermolecular interaction in the lattice is complicated, and the melting point fluctuates greatly. Simple alkyl groups, or near normal temperature, and long-chain or multi-branched alkyl groups, have a melting point or drop, or have a liter. It is difficult to generalize.
Its solubility is multi-soluble in organic solvents, such as dichloromethane, chloroform, and acetone. Due to the principle of similar miscibility, this pyridine derivative is quite polar, and can form hydrogen bonds or dipole-dipole interactions with polar organic solvents, so it is well miscible with each other. However, in water, due to its hydrophobic alkyl and fluorine groups, the solubility is very small, only a little soluble, floating on water, or slightly opaque state.
Its chemical properties, fluorine groups are active and have strong electron absorption, resulting in uneven electron cloud density of the pyridine ring, and the reactivity becomes easy. Electrophilic substitution on the ring is more difficult than that of ordinary pyridine, and often requires strong activation conditions or special catalysts. In the case of nucleophilic substitution, fluorine atoms can be used as leaving groups. In suitable bases and solvents, new substitutions can be generated with nucleophilic reagents such as alkoxides and amines.
And it contains trifluoromethyl, which has high stability and special electronic effects, which can affect the overall reactivity of molecules. For example, in oxidation and reduction reactions, it can be used as protecting groups or affect the reaction check point and rate, making the reaction path different from conventional pyridine compounds.

I look at what you said about "2,6-difluoro-3-alkyl-4- (trifluoromethyl) pyridine", which is a chemical substance. However, it is not easy to know its price range in the market. The price often varies due to many factors.
First, the price of raw materials has a great impact. If the raw materials for generating this compound are difficult to obtain, the price also varies. If the raw materials are scarce and rare, their price will be high; if they are easy to obtain, the price may be slightly flat.
Second, the difficulty of preparation is also critical. If the preparation process is complicated, special equipment and processes are required, and the technical requirements are extremely high, the manpower and material resources are consumed, and the price is high; if the preparation is relatively simple, the price may be close to the people.
Third, the supply and demand relationship in the market is an important factor. If the demand for this product is strong and the supply is limited, the price will rise; if the demand is flat and the supply is sufficient, the price may decline.
However, it is difficult to determine the exact price range. However, with common sense, if it is a special product of fine chemical industry, the preparation is complex and the demand is specific, the price may reach tens or even hundreds of yuan per gram; if it is common and easy to prepare, it may range from tens or even tens of yuan per gram. This is all speculation and is for reference only. The actual price can only be known after detailed investigation of the chemical market trading conditions and the quotations of relevant manufacturers.

2% 2C6-difluoryl-3-alkyl-4- (trifluoromethyl) pyridine This compound is in the chemical industry, and many manufacturers have their own strengths.
In the land of Huaxia, there is Beijing Rui'erfeng Chemical, which is good at fine chemical industry, exquisite process, and excellent raw material selection. For the production of 2% 2C6-difluoryl-3-alkyl-4- (trifluoromethyl) pyridine, the quality is strictly controlled, and the analysis and detection are microscopic. The product has high purity and few impurities. It is very popular in the manufacture of electronic and pharmaceutical intermediates.
Shanghai's search banner biochemical technology, rich in products and strong in research and development. For this compound, the R & D investment is large, the technology is updated quickly, it can meet the diverse needs of the market, the specifications are diverse, the packaging is excellent, and it has a good reputation in scientific research institutions, universities and other academic research fields.
Wengjiang Chemical Reagents in Guangdong, mainly for reagent production, complete production line, strict quality system. When producing 2% 2C6-difluoryl-3-alkyl-4- (trifluoromethyl) pyridine, it follows standard specifications, pays attention to the balance of cost and efficiency, and the product is cost-effective. It is widely used in chemical experiments, industrial small tests, etc.
There are also strong overseas, such as Sigma-Aldrich in the United States, which is famous and has a global circulation of products. For 2% 2C6-difluoryl-3-alkyl-4- (trifluoromethyl) pyridine, the research and development background is thick, the quality is high, and the certification is complete. It has a strong position in high-end scientific research, multinational pharmaceutical companies and other high-end markets.
TCI Chemicals is famous for fine chemicals. Its production of 2% 2C6-difluoryl-3-alkyl-4- (trifluoromethyl) pyridine, focusing on quality and innovation, exquisite technology and comprehensive service, has occupied a place in the international chemical market.