2 6 Difluoropyridine 4 Boronic Acid Pinacol Ester
pyridine pyrrole pyrazine piperidine piperazine

2,6-Difluoropyridine-4-boronic acid, pinacol ester

    Specifications

    HS Code

    860663

    Chemical Formula C11H14BF2NO2
    Molecular Weight 239.04
    Appearance Solid (Typical)
    Purity Typically High Purity in Reagent Grade
    Melting Point Data Depends on Purity and Measuring Conditions
    Solubility Soluble in Some Organic Solvents like Dichloromethane, Tetrahydrofuran
    Stability Stable Under Normal Conditions, Protect from Moisture
    Hazard Class May Have Irritant Properties, Check SDS for Details
    Cas Number 1073354-50-2
    Usage Used in Organic Synthesis for Cross - Coupling Reactions

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    Frequently Asked Questions

    As a leading 2,6-Difluoropyridine-4-boronic acid, pinacol ester supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 2,6-difluoropyridine-4-boronic acid pinacol ester?
    2% methyl 2C6-diethoxybenzene-4-sulfonate, which was not available in the era of Tiangongkai. However, from today's perspective, its uses are generally as follows.
    First, in the field of organic synthesis, it is often used as a key intermediate. In its molecular structure, ethoxy and methyl sulfonate groups give it unique reactivity, and can be derived from a wide range of organic compounds through various chemical reactions, such as nucleophilic substitution, esterification, etc. Such as the synthesis of drugs with specific structures and fine chemicals, which can be used as starting materials to follow established reaction paths to construct complex molecular structures, which are important cornerstones of organic synthetic chemistry.
    Second, it is also of considerable value in the field of materials science. Due to the hydrophilicity of methyl sulfonate group and the hydrophobicity of ethoxy group, the amphiphilic structure makes it possible to prepare surfactants or amphiphilic polymers with special properties. Such materials have potential applications in emulsion polymerization, drug delivery systems, self-assembled materials, etc. They can reduce the surface tension of liquids, promote the mixing of insoluble substances, or build stable micro-nano structure systems to achieve specific functions.
    Third, in some industrial production processes, or play the role of additives. For example, in the coatings and ink industries, its addition may improve product rheological properties, drying speed, adhesion, and other characteristics, enhance product quality and performance, and meet the needs of different industrial scenarios.
    What are the synthesis methods of 2,6-difluoropyridine-4-boronic acid pinacol ester?
    2% 2C6-diethoxybenzene-4-sulfonate sodium, this is an organic compound. The synthesis method, under the paradigm of the ancient book "Tiangong Kaiwu", can be expressed as follows:
    Start, select the refined benzene as the base material, and introduce the sulfonic acid group by the method of sulfonation. Put the benzene and an appropriate amount of fuming sulfuric acid in a special reactor in a certain ratio. The kettle must maintain a specific temperature and pressure so that the two can fully blend and react. During this process, keep a close watch and control the temperature in a suitable range to prevent side reactions from breeding.
    When the sulfonic acid group is successfully introduced, 4-sulfonic acid benzene is obtained. Then, add an appropriate amount of ethanol and a strong base, such as sodium hydroxide. The molar ratio of ethanol to 4-sulfonated benzene, when precisely prepared, must also be appropriate for the amount of strong base. After condensation, the ethoxy group of ethanol can gradually replace part of the sulfonate group, and finally obtain 2% 2C6-diethoxybenzene-4-sulfonic acid.
    However, this product is not 2% 2C6-diethoxybenzene-4-sulfonic acid, and it must be neutralized again. Place 2% 2C6-diethoxybenzene-4-sulfonic acid in another reaction vessel, and slowly add a sodium salt solution, such as sodium carbonate solution. Stir while adding, so that the two fully react, the sulfonic acid group combines with sodium ions, and then forms 2% 2C6-diethoxybenzene-4-sodium sulfonate.
    After the reaction is completed, use suitable separation and purification means, such as crystallization, filtration, washing, etc., to obtain a pure 2% 2C6-diethoxybenzene-4-sodium sulfonate product. The whole operation must strictly follow the procedures and pay attention to safety to obtain the ideal synthetic effect.
    What is the market price of 2,6-difluoropyridine-4-boronic acid pinacol ester?
    Today, there are 2,6-diethylnaphthalene-4-sulfonate. How is the market? I will discuss it for you.
    The determination of the market depends on many factors. First, the cost of raw materials. If the raw materials of this compound are not easy to obtain or difficult to harvest, its price will be high. If the raw materials are widely sourced and easily available, the price may be slightly flat.
    Second, the difficulty of preparation. If the preparation requires exquisite methods, complex sequences, or rare reagents and harsh conditions, the production cost will increase greatly, and the market will also rise. On the contrary, if the preparation is convenient, the price is expected to be close to the people.
    Third, the supply and demand of the market. If there is a strong demand for this product in the fields of chemical industry, medicine, etc., but the supply is limited, the price will rise. If there is little demand and sufficient supply, the price may decline.
    Fourth, the production scale also has an impact. In large-scale production, due to the scale effect, the unit cost may be reduced, and the market may be more competitive; in small-scale production, the unit cost is higher, and the price will also be affected by it.
    However, I do not have the exact market information, but can only say that the price varies according to the above factors. To know the exact market, you can consult chemical raw material suppliers, trading platforms, or people in related industries to find out.
    How is the stability of 2,6-difluoropyridine-4-boronic acid pinacol ester?
    The stability of 2% 2C6-divinylpyridine-4-sulfonate pyridine buzzing salt is related to many physicochemical properties. Let me analyze it in detail.
    The stability of this compound first involves its chemical structure. The part of 2,6-divinylpyridine contains conjugated double bonds, and the conjugated system can cause electron cloud delocalization and increase molecular stability. However, the double bonds are reactive, and the stability of pyridine buzzing salt is damaged by electrophilic reagents, free radicals, etc. 4-sulfonate pyridine buzzing salt is positively charged, and the sulfonate group has strong electron-absorbing properties, which reduces the electron cloud density of the pyridine ring and increases the stability of the pyridine buzzing salt. However, the positive electric center will also lead to the attack of nucleophiles and cause structural changes.
    Temperature has a great impact on its stability. Heating up can increase the thermal motion of molecules, so that molecules can obtain enough energy to exceed the reaction energy barrier, causing decomposition, polymerization and other reactions to accelerate and reduce stability. At high temperatures, double bonds or thermal polymerization reactions destroy the original structure. At low temperatures, the molecular thermal motion is slow, the reaction rate is slow, and the stability is relatively increased. The pH value of the
    environment is also critical. In acidic environments, the positive electric centers of pyridinium sulfonate salts are less affected by protonation, and the structure is relatively stable. However, in an alkaline environment, hydroxide ions either attack the positive electric center of pyridine buzzing salt, or react with double bonds, causing structural damage and greatly reducing stability.
    Lighting cannot be ignored either. Light contains energy, or causes molecular electron transitions, producing excited molecules, which greatly increases activity and triggers photochemical reactions, such as double bond photopolymerization, which damages its stability.
    In summary, the stability of 2,6-divinylpyridine-4-sulfonate pyridine buzzing salt is restricted by many factors. To increase its stability, temperature control, pH adjustment, and protection from light are required to ensure its structural stability during storage and use.
    What are the storage conditions for 2,6-difluoropyridine-4-boronic acid pinacol ester?
    2% 2C6-divinylpyridine-4-sulfonate pyridine buzz salt should be stored in a cool, dry and well-ventilated place. Do not expose to sunlight, and avoid near fire and heat sources to prevent its properties from mutating.
    This product may be stable at normal temperature. However, if the temperature is too high, it may cause decomposition. It is better to control it in a suitable temperature range, between 15 and 25 degrees Celsius. Humidity should also be paid attention to. Excessive humidity, or allowing it to absorb moisture, affects the quality, so the ambient humidity should be maintained between 40% and 60%.
    In addition, when storing, it should be separated from oxidants, acids, bases and other substances to avoid chemical reactions and damage their effectiveness. When storing, it should also be properly sealed to avoid excessive contact with air to prevent oxidation and other things. After taking it, seal it immediately and return it to the original storage place to ensure its constant quality. In this way, the 2% 2C6-divinylpyridine-4-sulfonate pyridine buzzing salt can be well protected so that it can develop its due effectiveness when used.