2 6 Dichloro 4 Nitropyridine
pyridine pyrrole pyrazine piperidine piperazine

2,6-Dichloro-4-nitropyridine

    Specifications

    HS Code

    929785

    Chemical Formula C5H2Cl2N2O2
    Molar Mass 192.988 g/mol
    Appearance Yellow solid
    Melting Point 122 - 126 °C
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform

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    General Information
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    Frequently Asked Questions

    As a leading 2,6-Dichloro-4-nitropyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2,6-dichloro-4-nitropyridine?
    2% 2C6-difluoro-4-cyanopyridine is an important organic compound with key uses in the fields of medicine, pesticides, and materials.
    In the field of medicine, it is often used as a key intermediate for the synthesis of many drugs. For example, in the preparation of some anti-cancer drugs, 2% 2C6-difluoro-4-cyanopyridine can be converted into structural units with specific pharmacological activities through a series of chemical reactions. By precisely regulating the activity and selectivity of drug molecules, it can improve drug efficacy and reduce side effects. In the development of anti-cardiovascular drugs, it can also participate in the construction of a core skeleton, endowing drugs with better biological activity and pharmacokinetic properties.
    In the field of pesticides, 2% 2C6-difluoro-4-cyanopyridine is an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. After chemical modification and derivatization, insecticides with strong contact and stomach toxicity to pests can be prepared, or fungicides with good control effect on plant diseases. Such pesticides are environmentally friendly and have low residues, which can effectively protect crops while reducing adverse effects on the ecological environment.
    In the field of materials, 2% 2C6-difluoro-4-cyanopyridine can be used to synthesize high-performance organic optoelectronic materials. In the field of organic Light Emitting Diode (OLED), introducing it into the molecular structure of materials can optimize the electron transport performance and luminous efficiency of materials, and improve the brightness, contrast and service life of OLED devices. In the field of organic solar cells, it helps to improve the energy level matching and charge transfer of materials, thereby improving the photoelectric conversion efficiency of solar cells.
    In summary, 2% 2C6-difluoro-4-cyanopyridine has shown broad application prospects in many fields such as medicine, pesticides, and materials due to its unique chemical structure and reactivity, which is of great significance for promoting the development of related industries.
    What are the synthesis methods of 2,6-dichloro-4-nitropyridine?
    2% 2C6-difluoro-4-chloroaniline is an important intermediate in organic synthesis. The common synthesis methods include the following:
    First, 2,6-difluoroaniline is used as the starting material. After the diazotization reaction, the amino group is converted into a diazonium salt, and then interacts with a halogenating agent such as cuprous chloride to undergo a Sandmeier reaction, and the diazonium group is replaced by a chlorine atom to obtain 2,6-difluoro-4-chloroaniline. The reaction conditions of this route are relatively mild and the product purity is quite high, but the raw material 2,6-difluoroaniline is expensive, resulting in high production costs.
    Second, 4-chloro-2-nitroaniline is used as the starting material. First, a fluorination reagent, such as potassium fluoride, is used in the presence of a specific solvent and catalyst to carry out a fluorination reaction. The hydrogen atom at the nitro-ortho position is replaced by a fluorine atom to form 2-fluoro-4-chloro-2-nitroaniline. Subsequently, through a reduction reaction, the commonly used reducing agents such as iron powder, zinc powder and hydrochloric acid, or catalytic hydrogenation, the nitro group is reduced to an amino group, and the final product is 2,6-difluoro-4-chloroaniline. The raw materials of this method are relatively easy to obtain and the cost is slightly lower. However, the reaction steps are many, the operation process is complicated, and some reducing agents will produce a large amount of waste, which will cause pressure on the environment.
    Third, 2,6-dichloroaniline is used as the raw material. Selective fluorination is carried out by fluorination reagents, so that two of the chlorine atoms are replaced by fluorine atoms, and then 2,6-difluoro-4-chloroaniline is obtained. The key to this method is the selective control of the fluorination reaction. It is necessary to precisely regulate the reaction conditions and select the appropriate catalyst to achieve the ideal reaction effect. If the selectivity is not good, it is easy to generate a variety of by-products, which increases the difficulty of separation and purification.
    What are the physical and chemical properties of 2,6-dichloro-4-nitropyridine?
    2% 2C6-dioxy-4-chlorophenylpyridine is an organic compound with unique physicochemical properties.
    Looking at its physical properties, under normal conditions, this compound is mostly solid, and the structure is relatively stable due to intermolecular forces. Its melting point is closely related to the accumulation and interaction of molecules. It has been found by experiments that the melting point is within a specific range. This property is crucial for separation, purification and identification, and can be determined by melting point to determine its purity. In addition, solubility is also a key property. In common organic solvents, such as ethanol and acetone, their solubility varies, and their solubility in water is very small. This is due to the difference between molecular polarity and water molecular polarity. This property has a great impact on its application in different systems.
    When it comes to chemical properties, chlorine atoms in 2% 2C6-dioxy-4-chlorophenylpyridine are active and can undergo nucleophilic substitution reactions. When encountering nucleophilic reagents, chlorine atoms are easily replaced to form new derivatives, which provides the possibility for the construction of complex molecular structures in organic synthesis. In addition, pyridine rings are aromatic and can participate in various aromatic reactions, such as electrophilic substitution reactions. Under appropriate conditions, reagents can attack pyridine rings to generate different substitution products, providing a way for organic synthesis chemists to create a variety of compounds. Oxygen atoms in their molecules also affect the reactivity, or participate in coordination, forming complexes with metal ions, which have potential applications in catalysis and materials science.
    In summary, the physical and chemical properties of 2% 2C6-dioxy-4-chlorophenylpyridine are rich and diverse, and they show broad application prospects in many fields such as organic synthesis, materials science, and medicinal chemistry. Chemists can use their characteristics to develop new compounds and explore new applications.
    What are the precautions for storing and transporting 2,6-dichloro-4-nitropyridine?
    2% 2C6-dideuterium-4-nitrophenol, when storing and transporting, pay attention to many matters.
    The first storage environment. It should be placed in a cool, dry and well-ventilated place. Because the cool environment can avoid high temperature to cause its properties to change, the dry state can avoid moisture to cause qualitative change, and the good ventilation can timely disperse the harmful gases that may accumulate. If placed in a humid and warm place, or cause it to decompose and deteriorate, it will damage its quality and utility.
    Furthermore, when storing, it should be stored separately from oxidizing agents, acids, bases and other substances. 2% 2C6-dideuterium-4-nitrophenol is chemically active, encounters with oxidants, or reacts violently, causing the risk of combustion and explosion; contact with acids and alkalis may also cause chemical reactions, affecting its stability and safety.
    When transporting, the packaging must be tight. Suitable packaging materials are required to ensure that it is not damaged and leaked during transportation due to vibration, collision. If the packaging is not good, once it leaks, it will not only pollute the environment, but also pose a threat to the health of transporters and surrounding people.
    Transportation vehicles also need to be carefully selected. Those with appropriate safety facilities and protective devices should be selected, and drivers and escorts should be familiar with the characteristics and emergency treatment methods of 2% 2C6-dideuterium-4-nitrophenol. During transportation, follow the specified route to avoid densely populated areas and important facilities to ensure safety.
    What are the effects of 2,6-dichloro-4-nitropyridine on the environment and human health?
    2% 2C6-dichloro-4-nitrophenol, which has an impact on both the environment and human health.
    At the environmental end, its chemical properties are stable, difficult to degrade, and easy to accumulate in the environment. It can flow into water and soil by means of rainwater initialize, causing water quality and soil pollution. In water bodies, it will interfere with the normal physiological activities of aquatic organisms, destroy the balance of aquatic ecosystems, and cause abnormal behavior of aquatic organisms, inhibition of reproduction, and even death. In soil, it will affect the structure and function of soil microbial community, hinder the normal material cycle and nutrient transformation in soil, and then affect plant growth.
    It is related to human health. 2% 2C6-dichloro-4-nitrophenol is toxic. After entering the human body through skin contact, respiratory inhalation or accidental ingestion, it will interfere with the normal physiological metabolism of the human body. It can damage the nervous system, cause symptoms such as headache, dizziness, fatigue, and insomnia; it can also affect the function of organs such as the liver and kidneys, and cause substantial damage to organs after long-term exposure. In addition, it may be potentially carcinogenic and teratogenic, especially harmful to pregnant women and fetuses, or cause abnormal fetal development.
    Therefore, when producing and using products containing 2% 2C6-dichloro-4-nitrophenol, it is necessary to strictly follow safety regulations, take protective measures, and strengthen the supervision of its emissions to reduce the harm to the environment and human health.