2,6-Dichloro-4-iodopyridine

2% 2C6-difluoro-4-chloropyridine is an organic compound. Its chemical properties are as follows:
First, it has a halogenated pyridine structure, and the pyridine ring gives it a certain alkalinity. Nitrogen atoms can bind protons and form pyridine salts in acidic environments. This property is crucial in some reactions and separation processes.
Second, fluorine atoms at positions 2 and 6 are highly active with chlorine atoms at positions 4. Fluorine atoms have strong electronegativity, which can enhance molecular polarity, and the C-F bond energy is large and relatively stable. However, under certain conditions, such as coexistence with nucleophiles, nucleophilic substitution reactions can still occur. The 4-position chlorine atom is equally active, and the nucleophilic reagent is easy to attack the check point, causing the chlorine atom to be replaced and generating new organic compounds. Common nucleophilic reagents such as alkoxides and amines can be used to introduce different functional groups to expand the chemical synthesis path of the compound.
Third, the reactions participated in by this substance are often selective. The electron cloud of the pyridine ring is unevenly distributed, resulting in different check points for the nucleophilic substitution reaction. Due to the induction effect of fluorine and chlorine atoms and the conjugation effect, specific locations are more susceptible to attack by nucleophilic reagents, and this selectivity provides convenience for the precise construction of target molecules in organic synthesis. Fourth, under suitable catalyst and reaction conditions, 2% 2C6-difluoro-4-chloropyridine can participate in the coupling reaction, such as coupling with organometallic reagents containing boron and tin, thereby forming carbon-carbon bonds or carbon-heteroatomic bonds, laying the foundation for the synthesis of complex organic molecules.

2% 2C6-dichloro-4-nitroaniline, which has a wide range of uses. In the dye industry, it is a key intermediate for the preparation of a variety of dyes. For example, when synthesizing azo dyes, with its special chemical structure, through a series of chemical reactions, it can produce colorful and stable dyes. It is widely used in textiles, printing and dyeing and other fields to give rich colors to fabrics.
In the field of pesticides, it is also an important raw material. It can be used to synthesize pesticides with bactericidal and insecticidal effects. Because the molecular structure contains specific functional groups, it has inhibitory or killing effects on certain pests and pathogens, which helps to control pests and diseases in agricultural production and ensure crop yield and quality.
In the pharmaceutical and chemical industry, although it is not a direct pharmaceutical component, it provides the basis for the synthesis of some pharmaceutical intermediates. Its chemical properties can participate in specific reactions, lay the foundation for the construction of complex drug molecular structures, and promote the development of pharmaceutical research and development and production.
In short, 2% 2C6-dichloro-4-nitroaniline plays a key role in many fields of the chemical industry, contributing greatly to the improvement of product performance and functional expansion in various industries.

2% 2C6-difluoro-4-cyanopyridine is an important organic synthesis intermediate, and its synthesis methods are diverse. The following are common ones:
** 1. Take 2,6-difluoropyridine as the starting material **
1. ** Cyanogen halide method **:
React 2,6-difluoropyridine with cyanogen halides (such as cyanogen bromide, cyanogen chloride) in the presence of suitable bases (such as potassium carbonate, sodium carbonate) and organic solvents (such as acetonitrile, N, N-dimethylformamide). The base can capture the hydrogen on 2,6-difluoropyridine, making it a nucleophilic reagent to attack the cyanyl group in the halogenated cyanide, and the halogen atoms leave to form 2,6-difluoro-4-cyanopyridine. The reaction temperature is generally controlled at 60-100 ° C. This process needs to be carried out under anhydrous and oxygen-free conditions to avoid side reactions.
2. ** Trimethylsilocyanide method **:
2,6-difluoropyridine reacts with trimethylsilocyanide (TMSCN) under the action of metal catalysts (such as palladium and nickel catalysts). The metal catalyst first forms an active intermediate with trimethylsilocyanide, and then undergoes nucleophilic substitution with 2,6-difluoropyridine, and the silicon group leaves to form the target product. The reaction is usually carried out under mild conditions, with a temperature of about 40-60 ° C. The reaction solvent can be selected from toluene, dichloromethane, etc.
** Second, using pyridine derivatives as raw materials **
1. ** Pre-halogenation and then cyanidation method **:
Using a suitable pyridine derivative as the starting material, fluorine atoms are first introduced into the pyridine ring through a halogenation reaction (such as using chlorine gas, bromine or corresponding halogenation reagents) to generate 2,6-dihalogenated pyridine. Subsequently, in the presence of a phase transfer catalyst (e.g. tetrabutylammonium bromide), a cyanide reagent (e.g. potassium cyanide, sodium cyanide, etc.) is used to replace the halogen atom with a cyanide group to obtain 2,6-difluoro-4-cyanopyridine. The halogenation reaction temperature varies depending on the halogenation reagent, generally at 0-50 ° C; the cyanide reaction temperature is usually controlled at 80-120 ° C.
2. ** Direct cyanide method **:
For pyridine derivatives with suitable substituents, they can be directly reacted with the cyanide reagent under strongly basic conditions to generate 2,6-difluoro-4-cyanopyridine in one step. This method requires the choice of suitable base (such as sodium hydride, potassium tert-butyl alcohol, etc.) and reaction solvent (such as dimethyl sulfoxide), and the reaction temperature is generally 50-100 ℃. However, this method requires more stringent structural requirements for raw material pyridine derivatives, and specific substituents are required to promote the reaction.

What you are asking about is the market price of 2,6-difluoro-4-pyrimidinonitrile. However, the price of this product often varies due to various factors such as time and place, supply and demand, quality, etc. It is difficult to determine a fixed price.
In the easy market, if the raw materials are abundant, the production plants are numerous, the supply is sufficient, and there are few buyers, the price may decline. On the contrary, if the raw materials are scarce, the production is difficult, and there are many people who need them, the price will rise.
In addition, regional differences also have an impact. In prosperous cities and convenient transportation places, the logistics is smooth, the cost or low, and the price is also different. In remote places, transshipment is difficult, and the price may be higher.
And the difference in quality is also related to the price. Those with excellent purity and few impurities will be priced higher than those with crude.
If you want to know the exact price, you can consult chemical material suppliers, trade brokers, or platforms that check chemical product price information to get a more accurate figure. In short, its price is variable and depends on the specific situation.

2% 2C6-difluoro-4-chloropyridine is a special organic compound. When storing and transporting, many key matters need to be paid attention to:
First, storage. Due to its nature or certain activity, it should be placed in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent reactions caused by excessive temperature. The temperature of the warehouse should be strictly controlled, usually not exceeding 30 ° C. The humidity should also be maintained within a reasonable range to avoid excessive moisture and deterioration of the compound. At the same time, it should be stored separately from oxidizing agents, acids, alkalis, etc., and must not be mixed. Due to the chemical reaction of these substances or with 2% 2C6-difluoro-4-chloropyridine, dangerous conditions appear. In addition, the storage area should be equipped with suitable containment materials so that it can be dealt with in time when a leak occurs.
Second, transportation. Be sure to ensure that the packaging is complete and sealed before transportation to prevent leakage during transportation. Vehicles used during transportation should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. Be careful during driving to avoid bumps and collisions to prevent packaging damage. During transportation, you should follow the specified route and do not stop in densely populated areas and places with open flames. Transport personnel also need to undergo professional training, be familiar with the characteristics of the compound and emergency treatment methods, pay close attention to the status of the goods during transportation, and take effective measures immediately if any abnormalities are detected.