2,6-Dichloro-4-(hydroxymethyl)pyridine

2% 2C6 -difluoro-4- (cyanomethyl) pyridine, which is widely used. In the field of medicinal chemistry, it is often used as a key intermediate to create various drugs. For example, in the synthesis process of some antibacterial drugs, with its unique chemical structure, it can effectively participate in the reaction and build a drug molecular structure with specific biological activities, which makes great contributions to the fight against bacterial infections and diseases.
In the field of materials science, it also shows important value. It can be used to synthesize polymer materials with special properties, endowing materials with characteristics such as better stability and corrosion resistance, thus emerging in high-end fields such as electronic devices and aerospace, and helping to optimize the performance of related materials.
In addition, it is also an indispensable part of pesticide research and development. It can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. Through rational molecular design and reaction, pesticide products with good control effect on crop diseases and pests can be prepared, which escorts stable and high-yield agriculture.
Viewing its application, it plays a key role in the fields of medicine, materials and pesticides, and contributes significantly to the progress and development of related industries.

2% 2C6-difluoro-4- (methoxy) pyridine is an important compound commonly used in organic synthesis. Its physical properties are unique and related to many practical applications of this compound.
Looking at its properties, at room temperature and pressure, 2% 2C6-difluoro-4- (methoxy) pyridine is mostly in a colorless to light yellow liquid form. This state makes it fluid in some reaction systems, easy to disperse uniformly, and participates in various chemical reactions.
When it comes to the melting point, the melting point of this compound is relatively low, about -20 ° C to -15 ° C. The lower melting point means that under relatively mild conditions, it is easy to change from solid to liquid, which is conducive to participating in some reactions requiring liquid reactants in the molten state.
The boiling point is between about 140 ° C and 145 ° C. This boiling point value determines the operating temperature range during the heating separation and purification process. At a suitable temperature, it can be effectively separated from the reaction mixture by means of distillation.
Solubility is also a key property. 2% 2C6 -difluoro-4- (methoxy) pyridine is soluble in common organic solvents such as dichloromethane, chloroform, ether, etc. Good solubility makes it miscible with many organic reagents, providing a suitable homogeneous reaction environment for organic synthesis reactions, which greatly facilitates the reaction.
In addition, the density of the compound is about 1.25 g/cm ³, which is very important when it comes to solution preparation, reaction material measurement and other operations. It is helpful to accurately calculate the amount of each substance in the reaction and ensure that the reaction proceeds according to the expected stoichiometric ratio.
The physical properties of 2% 2C6-difluoro-4- (methoxy) pyridine lay the foundation for its application in organic synthesis and related fields. It is of great significance to study and master these properties to give full play to its role.

2% 2C6 -dideuterium-4- (fluoromethyl) pyridine, the chemical properties of this substance are relatively stable. In its structure, the pyridine ring is a relatively stable aromatic system, giving the compound a certain stability.
From the perspective of the substituent, the 2,6-position deuterium atom is substituted. Although the chemical properties of deuterium and hydrogen are similar, the isotope effect of deuterium can make the C-D bond stronger than the C-H bond, which enhances the stability of the molecular structure to a certain extent, making the reaction involving the C-D bond more difficult to occur. < Br >
4-position fluoromethyl substituent, fluorine atoms have strong electronegativity, and the electron-absorbing induction effect is significant. This effect will affect the electron cloud density distribution on the pyridine ring, reduce the electron cloud density of the pyridine ring, and reduce the electrophilic substitution reaction activity. At the same time, it also affects the molecular polarity, changing its solubility and other physical properties in different solvents.
However, although the whole is relatively stable, its structure may change when exposed to extreme conditions such as strong oxidants, strong acids, and strong bases. For example, under the action of strong oxidants, pyridine may be oxidized and destroyed; in the case of strong acids, strong bases, fluoromethyl groups or hydrolysis and other reactions, the molecular structure and properties will be changed.
Overall, 2% 2C6 -dideuterium-4- (fluoromethyl) pyridine is chemically stable under conventional conditions, but under specific harsh conditions, it may exhibit different chemical activities and reactivity.

To prepare 2,6-difluoro-4- (methoxy) pyridine, there are many methods, and the main ones are selected.
First, the pyridine derivative is used as the starting material. The fluorine atom is introduced at a specific position of the pyridine ring first, and the nucleophilic substitution reaction can be used to make the suitable halogenated pyridine interact with a fluorine-containing reagent, such as potassium fluoride, etc. Under the appropriate solvent and reaction conditions, the halogenated atom is replaced by a fluorine atom. Subsequently, a methoxy group is introduced. In this step, the halogenated pyridine derivative can be used to undergo nucleophilic substitution with alkoxides such as sodium methoxide, so that the halogenated atom is transposed to a methoxy group, and the target product is obtained.
Second, The pyridine ring is constructed from suitable raw materials, and the fluorine atom and methoxy group are introduced into the desired position at the same time. For example, the pyridine ring structure is constructed by condensation and cyclization of fluorine and methoxy-containing aldose, ketone and ammonia or amine, and the target compound is obtained after multi-step reaction.
Third, the transition metal catalysis method is used. Transition metal catalysts, such as palladium catalysts, are used to catalyze the reaction of halogenated pyridine derivatives with fluorine-containing reagents and methoxylation reagents. In this process, transition metals can activate the substrate, promoting the efficient progress of the reaction and obtaining the target product with high selectivity. However, this approach requires strict reaction conditions and catalysts, and requires fine regulation of reaction parameters, such as temperature, solvent, ligand, etc., to achieve the best reaction effect.
In short, the synthesis of 2,6-difluoro-4- (methoxy) pyridine has its own advantages and disadvantages. In practice, it is necessary to weigh the choice according to the availability of raw materials, cost, reaction conditions and product purity in order to achieve the synthesis goal of high efficiency, economy and environmental protection.

It is difficult to determine the price range of 2% 2C6 -difluoro-4- (methoxy) pyridine in the market. This is due to many factors, which can cause its price to change.
The first is the situation of supply and demand. If the product is more demanded and less supplied, the price may rise; if the supply exceeds the demand, the price may fall. Second is the difficulty of preparation. If the production requires propagation methods and high materials, the cost will increase and the price will be high; if the production is easy and cheap, the price may be close to the people. Furthermore, market competition also has an impact. Competing in the same industry, in order to compete for customers or reduce profits and prices; if there are few in the same industry, the price may be strong.
Looking at the market, the price of such chemicals may vary depending on the source and quantity. For small purchases, the price may be high, or tens or even hundreds of yuan per gram; if you ask for a large amount, the price may be reduced to tens to tens of yuan per gram due to economies of scale.
If you want to know the exact price, you need to consult the chemical material supplier in detail, or check the immediate price on the relevant trading platform to get a more accurate price range.