2 6 Dichloro 3 Trifluoromethyl Pyridine
pyridine pyrrole pyrazine piperidine piperazine

2,6-dichloro-3-(trifluoromethyl)pyridine

    Specifications

    HS Code

    373338

    Chemical Formula C6H2Cl2F3N
    Molar Mass 215.987 g/mol
    Appearance Colorless to light yellow liquid
    Boiling Point 193 - 195 °C
    Melting Point N/A
    Density 1.498 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents
    Vapor Pressure Low
    Flash Point 84 °C
    Stability Stable under normal conditions

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    General Information
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    Frequently Asked Questions

    As a leading 2,6-dichloro-3-(trifluoromethyl)pyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2,6-dichloro-3- (trifluoromethyl) pyridine?
    2% 2C6 -dioxo-3- (triethylmethyl) pyridine, which has important uses in many fields.
    In the field of medicine, it can be called a key intermediate in drug synthesis. Take some antibacterial drugs as an example, with the help of it, a specific chemical structure can be constructed, which greatly enhances the inhibitory and killing effect of the drug on bacteria. Or some neurological drugs, which can help form unique molecular configurations, act more precisely on nerve targets, regulate nerve transmission, and then treat related neurological diseases.
    In the field of materials science, it is also an important raw material. When preparing high-performance polymer materials, the introduction of this substance can significantly improve the properties of the materials. For example, to enhance the thermal stability of materials, so that materials can still maintain good physical properties and chemical stability in high temperature environments; to improve the mechanical strength of materials, so that materials are more durable, widely used in aerospace, automotive manufacturing and other industries that require strict material properties.
    In the field of organic synthesis, it is like a "magic key", opening the door to the synthesis of complex organic compounds. With its unique chemical structure and reactivity, it can participate in many organic reactions, helping to synthesize various organic compounds with special functions and structures, providing a powerful tool for organic chemistry research and innovation.
    2% 2C6 -dioxo-3- (triethylmethyl) pyridine plays an irreplaceable key role in many fields such as medicine, materials science, and organic synthesis due to its unique chemical properties, promoting the sustainable development and progress of these fields.
    What are the physical properties of 2,6-dichloro-3- (trifluoromethyl) pyridine?
    2% 2C6 -dideuterium-3- (triethoxy) pyridine is an organic compound with the following physical properties:
    In appearance, it often appears as a colorless to light yellow transparent liquid, which exists stably at room temperature and pressure. This form is convenient for its operation and application in many chemical reactions and industrial processes.
    In terms of melting point, it is about -48 ° C. This lower melting point causes it to be liquid at room temperature, which greatly affects its storage and transportation conditions. It is necessary to avoid low temperature environments to prevent solidification. The boiling point of
    is between 260 and 262 ° C. A higher boiling point indicates that a higher temperature is required to convert it from liquid to gaseous state. This property is of great significance in chemical operations such as distillation and separation, which is conducive to the separation of impurities with low boiling points. The density of
    is about 1.12 g/cm ³, which is slightly heavier than water. In the process of mixing and delamination, its density characteristics determine its position and distribution in the system, and have a profound impact on the design and operation of related processes.
    In terms of solubility, it is soluble in some organic solvents, such as ethanol, ether, etc., but insoluble in water. This difference in solubility is a key consideration in the extraction, purification and selection of reaction media, and can be used to separate and purify the compound. The refractive index of
    is about 1.521-1.523. This optical property has potential applications in the field of optical materials and analytical testing. By measuring the refractive index, the purity and concentration of the compound can be identified.
    What are the synthesis methods of 2,6-dichloro-3- (trifluoromethyl) pyridine?
    To prepare 2,6-difluoro-3- (triethoxyformyl) pyridine, there are various methods. Common ones include the following:
    First, a compound containing a pyridine structure is used as the starting material and a fluorine atom is introduced through a halogenation reaction. If a suitable pyridine derivative is selected, under specific reaction conditions, it can be treated with a halogenating agent to replace a specific position on the pyridine ring with a fluorine atom to construct a 2,6-difluoropyridine skeleton. Subsequently, triethoxyformyl is introduced through an acylation reaction. The acylation process requires the selection of suitable acylation reagents and catalysts. In the appropriate reaction environment, it can react with 2,6-difluoropyridine to achieve the synthesis of the target product.
    Second, the strategy of gradually constructing a pyridine ring can also be used. Start with a small molecule compound containing fluorine, and gradually build a pyridine ring structure through a multi-step reaction, such as nucleophilic substitution and cyclization. In the process of constructing a pyridine ring, the reaction sequence and conditions are cleverly designed, and difluoro groups and triethoxy formyl groups are introduced simultaneously or sequentially. This strategy requires precise control of each step of the reaction to ensure that the reaction proceeds in the expected direction to obtain a product with higher yield and purity.
    Third, the reaction catalyzed by transition metals can be considered. Transition metal catalysts often show unique performance in organic synthesis. For example, with suitable transition metal catalysts, fluorine-containing substrates are coupled to compounds containing pyridine fragments to form the key skeleton of the target molecule. At the same time, using the selectivity of transition metal catalysis to achieve functionalization at specific locations, 2,6-difluoro-3- (triethoxyformyl) pyridine can be efficiently synthesized.
    All these synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to carefully choose the appropriate synthesis path according to many factors such as the availability of raw materials, the ease of control of reaction conditions, cost considerations, and the purity requirements of the target product, in order to achieve the purpose of efficient and economical synthesis.
    What are the precautions for storing and transporting 2,6-dichloro-3- (trifluoromethyl) pyridine?
    2% 2C6 -dioxo-3- (triethoxy) pyridine This product requires many precautions during storage and transportation.
    First chemical stability. Its structure contains specific functional groups, which may react violently or even cause ignition and explosion when exposed to high temperature, open flame or strong oxidant. Therefore, storage should be in a cool, dry and well-ventilated place, away from fire and heat sources, and should not be mixed with oxidants.
    Second and packaging integrity. Packaging must be tight to prevent leakage. Once leaked, the substance may react with surrounding substances, which will not only damage product quality, but also endanger the environment and personal safety. When transporting, it is also necessary to ensure that the packaging is not damaged by bumps and collisions.
    Furthermore, it is related to protective measures. Storage and transportation personnel should wear appropriate protective equipment, such as protective clothing, gloves and goggles. Because it may be irritating to the skin, eyes and respiratory tract, inadvertent contact can cause discomfort and even injury.
    In addition, it is also crucial to know emergency treatment methods. In the event of a leak, when the leak area is quickly isolated and personnel are restricted from entering and leaving, emergency personnel need to wear self-contained positive pressure breathing apparatus, wear anti-toxic clothing, and take appropriate methods to contain and remove according to the leakage situation.
    In short, during the storage and transportation of 2% 2C6-dioxy-3- (triethoxy) pyridine, it is necessary to be cautious and operate in strict accordance with regulations to ensure personnel safety, environmental damage and product quality.
    What are the environmental effects of 2,6-dichloro-3- (trifluoromethyl) pyridine?
    2% 2C6-dichloro-3- (triethoxy) pyridine, this substance is particularly critical to the environment and cannot be ignored.
    In the atmosphere, if it evaporates and escapes, some of it will chemically react with active substances in the atmosphere, generate new pollutants, or participate in photochemical reactions, resulting in the intensification of harsh environmental phenomena such as photochemical smog, affecting air quality, endangering human respiratory and eye health.
    In aquatic ecosystems, it can enter water bodies through surface runoff, wastewater discharge, etc. Because of its stable chemical structure, it is not easy to degrade, and will persist in water for a long time, it is significantly toxic to aquatic organisms. It may cause abnormal behavior, growth impairment, and even death of fish, shellfish, and other organisms, thereby destroying the balance of aquatic ecosystems and affecting the stability of the food chain.
    The soil environment is also affected by it. If the substances containing this substance enter the soil, it will adsorb on the surface of soil particles, change the physical and chemical properties of the soil, hinder the normal activities of microorganisms and material circulation in the soil, be unfavorable to the growth and development of plant roots, or reduce the yield and quality of crops, and pass through the food chain, threatening human health.
    And because it is difficult to degrade naturally, it is easy to accumulate in the environment, and affect the environmental quality and ecological balance for a long time. Therefore, such compounds should be strictly controlled in the production, use, discharge and other links, and try to reduce their harm to the environment to protect the tranquility of the ecological environment.