2,6-Dibromo-4-methylpyridine

2% 2C6-dibromo-4-methylpyridine is an organic compound with specific physical properties. It is mostly a crystalline solid at room temperature, and its appearance is usually white to light yellow. This color is related to purity. Those with high purity are light in color. The melting point of
is critical, between 105 and 107 degrees Celsius. This value is an important basis for identifying and purifying this compound. When heated to this temperature range, the substance melts from solid to liquid. The boiling point of
is about 280 degrees Celsius, indicating that when heated to this temperature at normal pressure, the compound will change from liquid to gas. However, due to its possible decomposition at high temperatures, the distillation operation needs to be cautious, or distillation under reduced pressure is required to reduce the boiling point and ensure the stability of the compound.
In terms of solubility, it is insoluble in water. Due to the existence of pyridine ring and bromine atom and methyl group in its molecular structure, the molecular polarity is very different from that of water. According to the principle of "similar miscibility", it is insoluble in water. However, it is soluble in common organic solvents, such as dichloromethane, chloroform, ether, acetone, etc. In organic synthesis reactions, these organic solvents often act as reaction media to help it fully dissolve and make the reaction proceed smoothly.
In addition, the density of 2% 2C6-dibromo-4-methyl pyridine is greater than that of water. If mixed with water, it will sink to the bottom. Its chemical properties are relatively stable at room temperature and pressure, and when it encounters strong oxidizing agents, strong acids, and strong bases, or chemical reactions occur, it is necessary to avoid contact with such substances during storage and use.

2% 2C6-dibromo-4-methylphenol, its main uses are as follows:
First, in the field of pharmaceutical synthesis, this compound is often a key intermediary. It can be modified and transformed by specific chemical reaction steps, and then participate in the construction of many biologically active drug molecules. For example, in the synthesis path of some antibacterial drugs, the chemical structure of 2% 2C6-dibromo-4-methylphenol allows it to be cleverly combined with other organic reagents. After a series of reactions, it generates drug components with antibacterial efficacy, providing an important material basis for pharmaceutical research and development.
Second, in the field of materials science, it also has important applications. Because its molecular structure contains bromine atoms and phenolic hydroxyl groups, this gives it some special properties. For example, in the preparation of flame retardant materials, 2% 2C6-dibromo-4-methylphenol can be integrated into it as an active component of flame retardants. When the material encounters a fire source, bromine atoms will undergo a series of chemical reactions at high temperature to form a barrier layer, inhibiting the progress of combustion reactions, thereby improving the flame retardant performance of the material. It is widely used in various plastic products, fiber fabrics, etc., to enhance its fire safety performance.
Thirdly, in organic synthesis chemistry experiments, 2% 2C6-dibromo-4-methylphenol is a commonly used reagent. Because of its active functional groups, chemists can use it to carry out various reaction studies and explore the synthesis methods and paths of new organic compounds. By changing the reaction conditions and the combination of reactants, 2% 2C6-dibromo-4-methylphenol can be used as the starting material to synthesize organic compounds with diverse structures and functions, promoting theoretical research and technological innovation in the field of organic chemistry.

To prepare 2,6-dibromo-4-methylphenol, the methods are as follows:
First, start with p-methylphenol. The target can be obtained by the reaction of p-methylphenol brominated. First, put p-methylphenol and an appropriate amount of bromine in a suitable solvent, such as dichloromethane, and add bromine dropwise at low temperature and slowly. Because the phenolic hydroxyl group is a strong activating group, the electron cloud density of the phenyl ring is greatly increased, and the bromine is easy to electrophilically attack the phenyl ring. By controlling the amount of bromine and the reaction conditions, bromine can mainly replace the hydroxyl ortho-position on the phenyl ring to obtain 2,6-dibromo-4-methylphenol. The reaction conditions are mild and easy to operate, but the amount of bromine and the reaction temperature need to be precisely controlled, otherwise it is easy to cause the formation of polybrominates.
Second, starting from p-toluidine. First, p-toluidine is diazotized, and p-toluidine is formed into a diazonium salt with sodium nitrite and hydrochloric acid at low temperature. After a Sandmeier reaction with cuprous bromide and hydrobromic acid, the diazonium group is replaced by a bromine atom to obtain p-bromotoluene. The p-bromotoluene is then alkylated by Fu-g, and the aluminum trichloride is used as a catalyst to react with acetyl chloride to introduce an acetyl group into the methyl para-position to obtain 4-bromo-4 '-methylacetophenone. The ketone is reduced by Clemenson, and the carbonyl group is reduced to methylene with zinc amalgam and concentrated hydrochloric acid to obtain 4-bromo-4 '-methyltoluene. Finally, through oxidation, hydrolysis and other steps, the methyl is oxidized to the carboxyl group, and then decarboxylated to obtain p-bromophenol, and p-bromophenol is brominated to obtain 2,6-dibromo-4-methylphenol. This path step is complicated, but the position of the substituent can be precisely controlled, and the product purity may be higher.
Third, m-bromomethylbenzene is used as the raw material. M-bromotoluene is first nitrified. Concentrated sulfuric acid and concentrated nitric acid are mixed as nitrifying reagents. At a suitable temperature, the nitro group mainly enters the methyl metaphase to obtain 4-bromo-2-nitrotoluene. The nitro compound is reduced, and iron and hydrochloric acid are used as reducing agents, and the nitro group is changed to an amino group to obtain 4-bromo-2-aminotoluene. After diazotization and hydrolysis, the amino group is converted into a hydroxyl group to obtain 2-bromo-4-methylphenol. Finally, bromination can produce 2,6-dibromo-4-methylphenol. There are many steps in this way, and the reaction conditions of each step need to be carefully controlled to ensure the smooth progress of the reaction and the purity of the product.

2% 2C6-dibromo-4-methylphenol requires attention to many points during storage and transportation.
One is related to storage. This substance should be stored in a cool, dry and well-ventilated place. Due to its relatively active chemical properties, it is easy to cause it to deteriorate in a high temperature and humid environment. If placed in a high temperature, or cause it to undergo chemical reactions, it will affect the quality; in a humid environment, it is prone to moisture hydrolysis, which in turn changes its chemical structure and properties. And it needs to be kept away from fires and heat sources. Because of its flammability, it may cause combustion hazards in case of open flames and hot topics. It should be stored separately from oxidants and acids to avoid reactions caused by mixed storage, resulting in dangerous conditions.
Second, about transportation. The transportation process must ensure that the packaging is complete and sealed. If the packaging is damaged and the substance leaks, it may not only pollute the environment, but also pose a threat to the health of the transportation personnel. Vehicles selected during transportation must have corresponding fire and explosion-proof facilities to deal with possible unexpected situations. During transportation, it should be protected from exposure to the sun, rain and high temperature. Summer transportation should be carried out in the morning and evening to avoid high temperature periods and reduce risks. At the same time, transportation personnel must undergo special training to be familiar with the characteristics of the substance and emergency treatment methods. In case of leakage and other accidents, they can be dealt with quickly and scientifically to reduce hazards.

Today I have a question, what is the approximate market price of 2,6-dibromo-4-methylpyridine? This is a rather professional chemical product, and its price varies due to factors such as quality, supply and demand, and market environment.
Under normal market conditions, if it is an ordinary purity industrial-grade product, its price may be several hundred yuan per kilogram. If it is high purity, it is used in fine chemical synthesis, pharmaceutical research and development, etc., the price will rise sharply. High purity products may reach a range of several yuan per gram or even tens of yuan, which is converted to several thousand yuan per kilogram.
For example, when the market demand for this product is strong and the supply is relatively tight, the price often rises. On the contrary, if there is excess capacity and demand is weak, prices will decline. Furthermore, the prices produced by different manufacturers are also different due to differences in process and quality. For large factories, those with stable quality may have higher prices; for small factory products, the prices may be slightly lower.
In order to determine its precise market price, when consulting relevant chemical product suppliers, traders, or referring to real-time quotations on chemical product trading platforms, a more accurate number can be obtained.