2,6-Dibromo-3-aminopyridine

2% 2C6-dibromo-3-nitropyridine is a key organic synthesis intermediate that has important uses in many fields such as medicinal chemistry and materials science.
In the field of medicinal chemistry, it is mainly used to synthesize pharmaceutical molecules with specific biological activities. With the bromine atoms and nitro groups in its structure, molecules can be modified and expanded through various chemical reactions. For example, bromine atoms are highly active and can participate in nucleophilic substitution reactions, whereby various functional groups are introduced to optimize the activity, selectivity and pharmacokinetic properties of drugs. For example, when developing anti-tumor drugs, this intermediate can be used to build a library of compounds with unique structures, and potential anti-cancer active molecules can be obtained through screening. For example, in the development of antimicrobial drugs, specific groups are introduced to enhance the affinity and inhibitory effect of drugs on bacterial targets.
In the field of materials science, 2% 2C6-dibromo-3-nitropyridine can be used to prepare functional organic materials. The presence of nitro groups gives molecules specific electronic properties, while bromine atoms help to form specific intermolecular interactions, such as halogen bonds. This allows for the preparation of materials with unique electrical and optical properties. For example, it can be used to prepare organic semiconductor materials, which have potential applications in devices such as organic field effect transistors (OFETs) and organic Light Emitting Diodes (OLEDs). By rationally designing the material structure based on the intermediate, key performance indicators such as carrier mobility and luminous efficiency of the material can be adjusted, which lays the foundation for the development of high-performance organic electronic devices.

2% 2C6-dibromo-3-nitropyridine is an important intermediate in organic synthesis. The synthesis method is as follows:
First, pyridine is used as the starting material. Pyridine has a unique aromatic structure and can be brominated under appropriate conditions. By carefully selecting suitable brominating reagents, such as liquid bromine ($Br_2 $), and in the presence of suitable catalysts, such as iron powder ($Fe $) or iron tribromide ($FeBr_3 $), the 2nd and 6th positions of pyridine can be introduced into the bromine atom. This reaction process requires strict control of the reaction temperature and reaction time, because temperature and time have a great influence on the selectivity and yield of the reaction. If the temperature is too high, side reactions such as excessive bromination may occur; if the temperature is too low, the reaction rate will be slow and it will be difficult to achieve the desired reaction effect. After this step, 2,6-dibromopyridine can be obtained.
Subsequently, the nitration reaction of 2,6-dibromopyridine is carried out. It is crucial to choose the appropriate nitrification reagent. The commonly used nitrification reagent is mixed acid, that is, a mixture of concentrated sulfuric acid ($H_2SO_4 $) and concentrated nitric acid ($HNO_3 $). Under low temperature conditions, 2,6-dibromopyridine is carefully added to the mixed acid. At this time, the nitro group ($- NO_2 $) selectively replaces the hydrogen atom at the third position on the pyridine ring, resulting in the successful preparation of 2,6-dibromopyridine. During the nitration reaction, it is necessary to pay close attention to the change of the reaction temperature, because the nitration reaction is a strong exothermic reaction. If the temperature is not controlled properly, it may cause violent reactions and even lead to safety accidents.
In addition, there are other synthetic routes. For example, pyridine can be nitrified first to obtain 3-nitropyridine, and then 3-nitropyridine can be brominated to obtain the target product 2,6-dibromo-3-nitropyridine. However, in practice, due to the difference in electron cloud density at different positions on the pyridine ring, the reaction selectivity and reaction condition control of this sequence are different from the former, and need to be adjusted and optimized according to the specific situation.

2% 2C6-dibromo-3-nitropyridine is an organic compound. Its physical properties are as follows:
In terms of appearance, this compound is often in a solid state, and the specific color may vary slightly due to various factors such as purity, or it is a white to light yellow solid. Its melting boiling point is a key physical parameter. Despite the relevant accurate data, it needs to be carefully experimentally determined or referred to professional chemical literature. Due to the specific functional groups such as bromine and nitro, it has a specific polarity. This polarity has a great influence on its solubility. In common organic solvents, it may have a certain solubility, such as in halogenated hydrocarbon solvents such as dichloromethane and chloroform, or it has a good solubility. In alcoholic solvents, the solubility may be slightly inferior, but in water, due to the difference between polarity and water, the solubility may not be good.
In terms of density, due to the large relative atomic weight of bromine atoms, its density is higher than that of common organic compounds. And because its molecular structure contains bromine and nitro, it is also an important consideration for the stability of light and heat. Nitro has strong electron absorption, or the molecular chemical properties are more active. Under heat or light conditions, it may initiate chemical reactions, such as the reduction reaction of nitro groups. The physical properties of this compound need to be considered thoroughly in the process of preparation, separation, purification and application in the fields of organic synthesis and medicinal chemistry.

Today there are 2,6-dibromo-3-aminopyridine, and the price of its market is what everyone thinks. However, the price of the market often varies for various reasons, and it is difficult to hide it in one word.
First, the place where it is produced is different, and the price is different. If it is produced in a place rich in materials and well-made, its price may be slightly cheaper. The raw materials are easily available, the labor is saved, and the cost is reduced and the price is self-reducing. If it is produced in a place where materials are lacking and skills are poor, the price may increase. Because you need to ask for raw materials far away, it takes effort, and the cost is high, the price is high.
Second, the amount you ask for is also related to the price. If in the market, everyone needs this product, and the demand exceeds the supply, the price will rise. Such as the pharmaceutical industry, the research of new drugs needs this, and many pharmaceutical companies compete for it, the price will be high. On the contrary, if the demand is thin, the supply will exceed the demand, and the price will drop.
Third, the quality of the quality also makes the price different. Those who are of high quality, with a high standard, are good for all uses, and the price will be high. Those who are of poor quality, do not meet the standard, use them in short supply, and the price will be low.
And the state of the market, the change of time, can make the price move. Therefore, if you want to know the market price of 2,6-dibromo-3-aminopyridine, you should carefully consider the situation, inquire about all business, and observe the market movement, in order to obtain a more accurate price.

2% 2C6-dibromo-3-nitropyridine must pay attention to the following things during storage and transportation:
First, the packaging must be solid and tight. This compound is more active in nature. If the packaging is omitted, it is very likely to react with the external environment or cause leakage, endangering the surrounding environment and personal safety. Therefore, the packaging material needs to have good sealing and corrosion resistance to prevent it from reacting chemically with the packaging material itself.
Second, the storage environment should be carefully selected. It should be stored in a cool, dry and well-ventilated place. Because it is quite sensitive to temperature and humidity, high temperature is easy to promote its decomposition, and humidity can cause its deliquescence and deterioration. At the same time, it is necessary to keep away from fire and heat sources, and must not mix with oxidants, acids, alkalis and other substances. Due to its active chemical properties, contact with the above substances may cause violent chemical reactions and even explosions.
Third, the transportation process should not be underestimated. The transportation vehicle should be clean, dry, and equipped with corresponding protective facilities to prevent bumps, vibrations, rain and other conditions during transportation. Transportation personnel should also be familiar with the characteristics of this compound and emergency treatment methods. If an accident occurs on the way, they can respond quickly and properly.
Fourth, do a good job of marking and warning. Whether it is storage or transportation containers, warning labels such as "toxic and harmful", "flammable and explosive" should be clearly marked, so that everyone who comes into contact can know the danger and take appropriate protective measures.
In short, 2% 2C6 -dibromo-3 -nitropyridine needs to be treated strictly during storage and transportation, from packaging, storage environment, transportation process to label warnings, in order to ensure its safety and avoid accidents.