2 6 Di Tert Butylpyridine
pyridine pyrrole pyrazine piperidine piperazine

2,6-Di-tert-butylpyridine

    Specifications

    HS Code

    808497

    Chemical Formula C15H25N
    Molecular Weight 219.37 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 257 - 258 °C
    Melting Point −27 °C
    Density 0.886 g/cm³
    Flash Point 109 °C
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
    Pka ~4.2 (estimated, used for acid - base behavior indication)

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    General Information
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    Frequently Asked Questions

    As a leading 2,6-Di-tert-butylpyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2,6-di-tert-butylpyridine?
    2% 2C6-diacetylpyridine is an important chemical raw material in the field of organic synthesis. It has many main uses and is of key significance in both materials science and medicinal chemistry.
    In the field of materials science, this compound can be used as a building block for the preparation of functional materials with specific properties. Due to its unique molecular structure, it can endow materials with special properties such as fluorescence properties, electrical conductivity, and gas adsorption properties. For example, by coordinating with other organic ligands, metal-organic framework materials (MOFs) can be synthesized. Such MOFs materials exhibit excellent performance in gas storage, separation, and catalysis. The MOFs constructed by 2% 2C6-diacetylpyridine can efficiently adsorb specific gas molecules and achieve precise separation and storage of gases by virtue of their ordered pore structure and adjustable chemical properties.
    In the field of pharmaceutical chemistry, 2% 2C6-diacetylpyridine can be used as a key intermediate for drug synthesis. The active functional groups contained in its structure provide an opportunity for the modification and optimization of drug molecules. By chemically modifying it, different substituents can be introduced to adjust the physicochemical properties and biological activities of drug molecules. Many studies have shown that the derivatives synthesized from this compound as the starting material have good inhibitory or regulatory effects on specific disease targets, and are expected to be developed into new drugs.
    In conclusion, 2% 2C6-diacetylpyridine plays an indispensable role in the fields of materials science and medicinal chemistry due to its unique chemical structure, providing important support for the development of related fields.
    What are the physical properties of 2,6-di-tert-butylpyridine?
    2% 2C6-diacetylpyridine, an organic compound. Its physical properties are as follows:
    Viewed at room temperature, it is mostly in the state of light yellow to yellow crystalline powder, which is easy to observe and handle.
    Smell, with the smell of specific organic compounds, although not pungent and intolerable, it is also one of its characteristics.
    Measure its melting point, about 88-92 ℃. The characteristics of the melting point are of great significance in the identification and purification of this compound. The purity can be judged by the measurement of the melting point.
    As for the boiling point, it is about 272-274 ℃. The value of the boiling point is a key reference in the distillation operation of separating and refining the compound. < Br > talks about solubility, which is soluble in common organic solvents such as ethanol, chloroform, and dichloromethane. This solubility facilitates its use as a reactant or solvent in organic synthesis reactions, because it can be well mixed with other organic reagents to promote the smooth progress of the reaction. However, the solubility in water is very small, which is due to the fact that the molecular structure contains more hydrophobic groups.
    2% 2C6-diacetylpyridine has a moderate density, and the specific value will vary slightly depending on the measurement conditions. Density data are of great significance to the measurement and ratio of materials in chemical production and experimental operations.
    The above physical properties are indispensable basic information for studying the chemical behavior of 2% 2C6-diacetylpyridine, conducting related experiments and applying it in actual production.
    Is the chemical properties of 2,6-di-tert-butylpyridine stable?
    The chemical properties of 2% 2C6-diethylamino pyridine are quite stable. Because of its structure, the pyridine ring has aromatic properties, which endows the molecule with certain stability. Diethylamino is used as a substituent and is connected to the pyridine ring. Although a certain activity check point is introduced, the aromatic conjugate system of the pyridine ring can effectively disperse the electron cloud and reduce the reactivity of the activity check point.
    From the perspective of spatial structure, the steric resistance effect of the diethylamino group also contributes to its stability. When the steric resistance makes the external reagent close to the activity check point, it is necessary to overcome the spatial obstacle, reduce the reaction probability, and thus improve the stability. Under common environmental conditions, such as room temperature, normal pressure and ordinary light, 2% 2C6-diethylaminopyridine can maintain its own structure and does not easily decompose or rearrange.
    However, its stability may be challenged in extreme chemical environments such as strong oxidants, strong acids, and strong bases. Strong oxidants can disrupt the conjugated system of the pyridine ring, while strong acids and strong bases may protonate or deprotonate with diethylamino groups, and even trigger reactions such as ring opening of the pyridine ring. However, under normal chemical operation and storage conditions, 2% 2C6-diethylaminopyridine can be regarded as a relatively stable chemical compound, which makes it widely used in many fields such as organic synthesis and catalysis without the worry of easy structural change.
    What are the preparation methods of 2,6-di-tert-butylpyridine?
    The preparation methods of 2% 2C6-diacetylpyridine are as follows:
    First, pyridine is used as the starting material. Take an appropriate amount of pyridine, put it in a specific reaction vessel, and add a suitable acylating agent, such as acetyl chloride or acetic anhydride. The reaction system needs to be acylated under precisely controlled temperature and pressure conditions. During the reaction, a specific position on the pyridine ring will be substituted with the acyl group. After careful separation and purification steps, 2% 2C6-diacetylpyridine can be obtained. The reaction conditions of this path are relatively strict, and the requirements for reaction equipment and operation technology are quite high. However, the raw material pyridine is more common and has a relatively wide range of sources.
    Second, 2-methylpyridine is used as the starting material. 2-methylpyridine is put into the reactor, and the methyl group is first converted into a carboxyl group through an oxidation step to obtain 2-pyridinecarboxylic acid. Then, 2-pyridinecarboxylic acid and acetylation reagent are acylated under the action of a suitable catalyst. The acetyl group is introduced at the 6 position of the pyridine ring, and the reduction series of reactions is repeated. Finally, 2% 2C6-diacetylpyridine is prepared. This method is slightly complicated, but the controllability of the intermediate product is better, and the yield of each step is relatively stable.
    Third, with the help of a new strategy of organic synthesis, metal-organic complexes are used as catalysts to prepare cross-coupling reactions. Select suitable halogenated pyridine derivatives and acetylation reagents, and under the catalysis of metal-organic catalysts, cross-coupling reactions occur to directly construct the structure of 2% 2C6-diacetylpyridine. This approach has high reaction efficiency and good selectivity, but the catalyst cost is high, and the reaction requires extremely strict anhydrous and anaerobic conditions in the reaction environment.
    What are the precautions for storing and transporting 2,6-di-tert-butylpyridine?
    2% 2C6-di-tert-butylphenol has many points to pay attention to during storage and transportation.
    When storing, the first environment. It must be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its flammability, if the ambient temperature is too high or in case of open fire, it is easy to cause fire and endanger the surrounding safety. Explosion-proof type should be used for lighting, ventilation and other facilities in the warehouse, and the switch should also be located outside the warehouse to prevent the spark generated by electrical equipment from igniting this thing.
    Furthermore, pay attention to the isolation of other substances. Do not mix with oxidizers, acids, etc. Oxidants are highly oxidizing, and acids are chemically active. Both may chemically react with 2% 2C6-di-tert-butylphenol, causing it to deteriorate and even cause danger. For example, when encountering strong oxidants, it may cause a violent oxidation reaction, releasing a lot of heat, and then causing an explosion.
    When transporting, the packaging must be tight. Packaging materials that meet relevant safety standards should be used to ensure that there will be no damage and leakage due to bumps and collisions during transportation. Transportation vehicles must also be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment.
    During transportation, the choice of driving routes cannot be ignored. To drive according to the specified route, do not stop near densely populated areas and important places. If a leak occurs during transportation, drivers and passengers should take immediate emergency measures, evacuate the surrounding people, isolate the leaked contaminated area, strictly restrict access, and quickly report to the relevant departments.
    In short, 2% 2C6-di-tert-butylphenol is a safety concern during storage and transportation, and must not be taken lightly. It is necessary to operate in strict accordance with relevant norms and requirements to ensure foolproof.