2 6 Bis Trifluoromethyl Pyridine
pyridine pyrrole pyrazine piperidine piperazine

2,6-bis(trifluoromethyl)pyridine

    Specifications

    HS Code

    163164

    Chemical Formula C7H3F6N
    Molecular Weight 213.096
    Appearance Colorless to light yellow liquid
    Boiling Point 110 - 112 °C
    Density 1.409 g/cm³
    Solubility Soluble in organic solvents
    Flash Point 20.8 °C
    Refractive Index 1.389

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    General Information
    Where to Buy 2,6-bis(trifluoromethyl)pyridine in China?
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    Frequently Asked Questions

    As a leading 2,6-bis(trifluoromethyl)pyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2,6-bis (trifluoromethyl) pyridine?
    The main uses of 2% 2C6-bis (triethylamino) pyridine are as follows:
    This compound is used in the field of organic synthesis and its use is quite critical. First, it can be used as an efficient organic base catalyst. In many organic reactions, such as esterification and amidation reactions, it can effectively catalyze the reaction process, improve the reaction rate, and also have excellent regulation on the selectivity of the reaction. Due to its structural properties, it can moderately bind the reactants and promote the reaction to proceed in the direction of the desired product.
    Second, in some metal-catalyzed reaction systems, 2% 2C6-bis (triethylamino) pyridine can be used as a ligand. After coordination with metal ions, it can significantly change the electron cloud density and spatial structure of metal catalysts, thereby optimizing the performance of catalysts, enhancing catalytic activity and selectivity, and playing an indispensable role in the coupling reaction of transition metal catalysis.
    Furthermore, in the field of materials science, it may be involved in the preparation of functional materials. By reacting with other organic or non-organic components, materials with specific structures and properties can be constructed, such as for the preparation of polymer materials with special optical and electrical properties, etc., to provide assistance for the performance optimization and functional expansion of materials.
    In conclusion, 2% 2C6-bis (triethylamino) pyridine has shown important application value in many fields such as organic synthesis and materials science, promoting the research and development of related fields.
    What are the physical properties of 2,6-bis (trifluoromethyl) pyridine?
    2% 2C6 -di (triethylamino) pyridine, which is an organic compound. Its physical properties are as follows:
    Looking at it, it is mostly liquid at room temperature, transparent or slightly yellowish in color, like water and slightly different in color. Its shape is flowing, smooth to the touch, but slightly thicker in texture than water.
    Smell it, it has a special smell, not a rich fragrance, nor a rancid smell, but a unique smell of organic chemicals. It is pungent but not strong. Ordinary people smell it and have a deep impression.
    As far as the boiling point is concerned, due to factors such as intermolecular forces, the boiling point is quite high. Under a specific pressure, it needs to reach a certain temperature to boil and gasify. This characteristic makes it able to maintain a liquid state in a specific chemical reaction environment, providing a stable medium for the reaction.
    Its solubility also has characteristics. It can be well miscible in organic solvents such as ethanol and ether, just like a fish entering water, and it is fused infinitely. However, in water, the solubility is limited, only slightly soluble, like oil floating in water, and the two are difficult to integrate. This difference in solubility is due to the characteristics of its molecular structure, which contains hydrophobic groups, so its affinity in water is weak. < Br > And its density is slightly different from that of water, either heavier or lighter than water, depending on the specific chemical structure. This difference in density has an important impact on the separation of mixed systems and other operations. Depending on its density, separation and purification can be performed by layering.
    What are the synthesis methods of 2,6-bis (trifluoromethyl) pyridine?
    2% 2C6-di (triethylamino) pyridine is an important compound in organic synthesis. The synthesis method is as follows:
    The starting material is pyridine. After nitration, the nitro group is introduced at a specific position in the pyridine ring. This reaction needs to be achieved with a specific nitrifying agent under appropriate reaction conditions. Then the nitro group is reduced to an amino group. Common reduction methods include catalytic hydrogenation, metal and acid as reducing agents.
    When an amino group is successfully introduced into the pyridine ring, it can react with triethylamine. In this reaction, the reaction solvent and base need to be carefully selected to promote the smooth combination of the amino group and triethylamine, resulting in the formation of 2% 2C6-di (triethylamino) pyridine.
    Another way of thinking is to first halogenate the pyridine, so that the pyridine ring is connected to a halogen atom at a specific position. This halogenation reaction requires precise regulation of the reaction process according to the difference in halogen type and reaction conditions. Then, the halogen-containing pyridine derivative reacts with triethylamine under the action of an appropriate catalyst, and the target product is formed by nucleophilic substitution reaction.
    During the synthesis process, the control of reaction conditions is crucial. Factors such as temperature, reaction time, and the proportion of reactants all have a significant impact on the reaction yield and product purity. Through repeated experiments and optimization, the most suitable reaction conditions need to be found to achieve the purpose of efficient synthesis of 2% 2C6 -bis (triethylamino) pyridine. After each step of the reaction, it is often necessary to separate and purify the product by means of column chromatography, recrystallization, etc., to ensure that the reaction can proceed smoothly to the next step, and finally obtain a high-purity target product.
    What are the precautions for storing and transporting 2,6-bis (trifluoromethyl) pyridine?
    When storing and transporting 2% 2C6-bis (triethylamino) pyridine, many things need to be paid attention to. This substance is chemically active. When storing, the first thing to do is to choose a cool, dry and well-ventilated place, away from direct sunlight and heat sources, to prevent the temperature from being too high to cause chemical reactions or even cause danger. Because it may be volatile and irritating, the storage place should keep air circulation to avoid the accumulation of harmful gases.
    Furthermore, the storage container must have good sealing to prevent contact with air, moisture, etc. Choose containers of suitable materials, such as glass or specific plastic materials, to avoid contact with materials that are easy to react with.
    During transportation, it is necessary to pack in strict accordance with relevant regulations. The packaging should be sturdy and able to withstand certain external shocks and vibrations to prevent material leakage caused by damage to the container. Transportation vehicles should also be kept clean and dry to avoid mixing with other chemicals, especially those that may react with them.
    The escort personnel must be familiar with the characteristics of this substance and emergency treatment methods. If there is an accident such as leakage during transportation, they can respond quickly and appropriately. For example, in the event of a leak, the surrounding people should be evacuated immediately, the fire source should be blocked, and corresponding measures should be taken according to the leakage volume and site conditions, such as adsorption and collection with inert materials such as sand, and then proper disposal. Do not discharge at will to avoid polluting the environment. Overall, whether storing or transporting 2% 2C6-bis (triethylamino) pyridine, care must be taken to ensure the safety of personnel and the environment.
    What is the approximate market price of 2,6-bis (trifluoromethyl) pyridine?
    Today there are 2,6-bis (triethylamino) pyridine, which is roughly the market price? This is a fine chemical product, and its price often varies depending on quality, source, and purchase quantity.
    If the purchase quantity is very small, it is only used for laboratory small-scale tests. In terms of high-purity products, the price per gram may reach tens of gold. Because of its preparation method, it involves multi-step reactions, complicated processes, and high requirements for raw materials and equipment, the cost is not cheap.
    If it is purchased on an industrial scale and the quantity is in kilograms, the unit price should be reduced. However, its preparation requires fine operation, and the cost of raw materials is high, and the price per kilogram may be in the range of hundreds of gold.
    The quality of the suppliers in the market varies, the price of refined products is high, and the price of those who are slightly inferior is slightly lower. And the market supply and demand situation also affects its price. If there are many applicants, and there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price may drop.
    Therefore, if you want to know the exact price, you should consult the supplier of chemical raw materials, and ask for their detailed report in quantity and quality to get a price close to it.