2,6-Bis[(S)-4-phenyloxazolin-2-yl]pyridine

2% 2C6 - Bis [ (S) -4 - phenyloxazolin - 2 - yl] pyridine is an organic compound. It has a wide range of main uses and is particularly crucial in the field of organic synthesis.
First, it can act as a chiral ligand. In asymmetric catalytic reactions, it can combine with metal catalysts to create a chiral environment, thereby achieving precise control of the stereochemistry of the reaction. Taking asymmetric hydrogenation as an example, after complexing with a metal catalyst, this compound can selectively generate products of specific configurations, improve the enantioselectivity of the reaction, and provide an effective way to obtain compounds of a single chiral configuration.
Second, it also has applications in materials science. Due to its special structure and chiral characteristics, it can participate in the preparation of materials with special optical and electrical properties. For example, in the synthesis of chiral luminescent materials, the introduction of this compound may endow the material with unique circular polarization luminescence properties, showing potential value in display technology, optical sensors and other fields.
Furthermore, in the field of medicinal chemistry, it may be used as a structural unit of lead compounds. In view of the importance of chirality in drug activity and safety, structural modification and optimization based on this compound may lead to the development of high-efficiency and low-toxicity chiral drugs.
Overall, 2% 2C6 - Bis [ (S) -4 - phenyloxazolin - 2 - yl] pyridine has important uses in organic synthesis, materials science, medicinal chemistry and many other fields due to its unique structure, providing powerful tools and material basis for research and development in various fields.

To prepare 2,6-bis [ (S) -4-phenyloxazoline-2-yl] pyridine, a conventional number method is used. First, pyridine-2,6-dicarboxylic acid is used as the starting point, and pyridine-2,6-dicarboxylic acid is first heated with thionyl chloride to obtain pyridine-2,6-dicarboxylic acid chloride. This acid chloride reacts with (S) -4-phenyl-2-aminoethanol in the presence of a suitable acid binding agent, such as triethylamine, in an inert solvent, such as dichloromethane, to form the corresponding amide. After being catalyzed by a dehydrating agent, such as p-toluenesulfonic acid, it is heated and cyclized to obtain the target. < Br >
Second, using 2,6-dibromopyridine as the starting material, interacting with magnesium chips to make Grignard's reagent, and then reacting with (S) -4-phenyl-2-oxazoline-5-one, hydrolysis, dehydration and other steps can also achieve the purpose. In the reaction, Grignard's reagent has high activity and needs to avoid water and oxygen for operation.
Third, 2,6-diborate pyridine and (S) -4-halo-2-phenyl-oxazoline were prepared by Suzuki coupling reaction in the presence of palladium catalysis and base. This reaction condition is milder and has good selectivity, but the cost of palladium catalyst is higher.
All synthesis methods have their own advantages and disadvantages, and the actual application is selected according to factors such as raw material availability, cost, yield and purity requirements. During operation, the reaction conditions of each step need to be precisely adjusted to achieve the desired effect.

I have not seen the exact price of 2,6-bis [ (S) -4 -phenyloxazoline-2-yl] pyridine in the market. The price of this substance often changes due to multiple reasons. First, the difficulty of its preparation is the main reason. If its synthesis is difficult, it needs multiple steps of reaction, using rare raw materials and reagents, and the yield is not high, the price will be high. Second, the supply and demand of the market also affect its price. If there are many people who want it, and those who supply it are few, the price will also increase; conversely, if the supply exceeds the demand, the price will drop. Third, the quality of the quality is also related to the price. Those with high purity and high quality are often more expensive than those with inferior quality. In addition, different sellers have different prices. The goods of big merchants may be more affordable due to large regulations and low costs; small merchants may be slightly expensive due to high costs and small quantities. And, different places have different prices due to different taxes and transportation costs. Therefore, if you want to know the exact price, you should consult chemical reagent suppliers or visit chemical trading platforms to get a near-real price.

2% 2C6 - Bis% 5B% 28S% 29 - 4 - phenyloxazolin - 2 - yl% 5Dpyridine, this is an organic compound. Its physical and chemical properties are unique and related to many practical applications.
Looking at its physical properties, under normal circumstances, this substance may be in a specific state, either solid or liquid, depending on the environmental conditions. If it is solid or has a specific crystal structure, this structure affects its appearance and morphology, such as the shape and luster of the crystal. Its melting point is also a key physical property. When it reaches a specific temperature, the substance melts from solid to liquid. This temperature is of great significance for the maintenance and transformation of its morphology under different conditions.
As for chemical properties, because its molecular structure contains specific functional groups, it has unique chemical activities. The coexistence of the pyridine ring and the chiral oxazoline group allows the compound to participate in various chemical reactions. The nitrogen atom of the pyridine ring has lone pairs of electrons, which can be used as electron donors to participate in coordination chemical reactions and form coordination compounds with metal ions. This property may be used in the field of catalysis. The chiral oxazoline group endows it with chiral characteristics. In chiral catalytic reactions, it can selectively promote the generation of specific chiral products and improve the enantioselectivity of the reaction. It is widely used in the field of asymmetric synthesis. Its chemical stability cannot be ignored either. In different chemical environments, its tolerance to acid-base and redox conditions determines its scope and conditions of application in practical applications.

2% 2C6 - Bis% 5B% 28S% 29 - 4 - phenyloxazolin - 2 - yl% 5Dpyridine, an organic compound, is useful in many fields.
In the field of organic synthesis, it often acts as a chiral ligand. Chiral ligands play an important role in asymmetric catalytic reactions and can guide the reaction to produce products with specific chiral configurations. With the unique structure of this compound, the enantioselectivity and catalytic efficiency of the reaction can be significantly improved in many asymmetric synthesis reactions. For example, in some metal-catalyzed reactions, the complexes formed with metals can precisely control the stereochemical process of the reaction, providing an effective way for the synthesis of high-purity chiral compounds. < Br >
In the field of materials science, it also has applications. Because its structure imparts specific rigidity and spatial configuration to molecules, it can participate in the construction of functional materials with special properties. For example, it may be used to prepare materials with optical activity. Such materials may have potential applications in optical devices, such as liquid crystal displays, Light Emitting Diodes, etc., which can improve the optical properties of materials, such as improving luminous efficiency and adjusting luminous color.
In the field of medicinal chemistry, chiral compounds have a significant impact on drug activity. As a chiral ligand, this compound may assist in the synthesis of chiral drug molecules with specific biological activities. Through asymmetric catalytic synthesis, drugs with a single chiral configuration can be obtained, improving the efficacy of drugs and reducing side effects, which is of great significance for the development of new drugs.
In short, 2% 2C6 - Bis% 5B% 28S% 29 - 4 - phenyloxazolin - 2 - yl% 5Dpyridine has shown broad application prospects in the fields of organic synthesis, materials science and medicinal chemistry due to its unique structure and properties.