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What is the chemical structure of 2,6-Bis ((S) -4-phenyl-4,5-dihydrooxazol-2-yl) pyridine
2% 2C6 - Bis% 28% 28S% 29 - 4 - phenyl - 4% 2C5 - dihydrooxazol - 2 - yl% 29pyridine is the English name of an organic compound. After analysis, its corresponding Chinese name is 2,6 - bis (S) -4 - phenyl - 4,5 - dihydrooxazole - 2 - yl) pyridine.
The chemical structure of this compound, the pyridine ring acts as the core structure, and the 2nd and 6th positions are connected with (S) -4-phenyl-4,5-dihydrooxazole-2-yl, respectively. The oxazole ring is a five-membered heterocycle composed of one oxygen atom, one nitrogen atom and three carbon atoms. The phenyl group is connected at the 4th position, and the double bond is between the 4th and 5th positions. The 2nd position of the oxazole ring is connected with the 2nd and 6th positions of the pyridine ring by carbon-carbon bonds. In the (S) configuration, specific spatial arrangement rules are followed according to the priority order of chiral carbon atom linking groups. This structure endows the compound with unique chemical properties and potential application value. In the field of organic synthesis, it may be used as a ligand to complex with metal ions to catalyze specific chemical reactions. Its structural properties or affect intermolecular forces, which also affect its physical properties such as melting point, boiling point, solubility, etc.
What are the main uses of 2,6-Bis ((S) -4-phenyl-4,5-dihydrooxazol-2-yl) pyridine
2% 2C6 - Bis% 28% 28S% 29 - 4 - phenyl - 4% 2C5 - dihydrooxazol - 2 - yl% 29pyridine, the Chinese name is often 2,6 - bis ((S) - 4 - phenyl - 4,5 - dihydrooxazol - 2 - yl) pyridine. This substance is widely used in the field of chemical synthesis.
First, it is often used as a ligand in asymmetric catalytic reactions. The molecular structure of the Gain has a unique chiral oxazoline group, which can endow metal catalysts with excellent asymmetric induction ability. In this way, in many asymmetric synthesis reactions, such as asymmetric epoxidation of olefins, Diels-Alder reaction, etc., can promote the reaction to generate products of specific configurations, greatly improve the optical purity of the products, and are of great significance in the fields of pharmaceuticals and natural product synthesis.
Second, in the field of materials science, it also has its uses. Due to its special structure, it can complex with metal ions to form complex materials with specific properties. Such materials exhibit unique properties in optics, electronics, etc., and are expected to be applied to luminescent materials, sensor materials, and many other aspects. For example, the formed complexes may have the ability to selectively identify specific substances, thereby constructing high-sensitivity sensors.
Third, it can be used as a key intermediate in the study of organic synthesis methodologies. With the reactivity of its pyridine and oxazoline structures, it can carry out diverse organic reactions and derive a series of organic compounds with novel structures, providing new ways and methods for the development of organic synthesis chemistry and helping chemists explore more unknown chemical spaces.
What are the synthesis methods of 2,6-Bis ((S) -4-phenyl-4,5-dihydrooxazol-2-yl) pyridine
To prepare 2,6-bis ((S) -4-phenyl-4,5-dihydrooxazole-2-yl) pyridine, there are many common synthesis methods.
First, pyridine is used as the starting material, and a suitable functional group is introduced at the 2,6 position of pyridine, and then the oxazole ring structure is constructed through a series of reactions. For example, a halogen atom, such as a bromine atom, is first introduced at the 2,6 position of pyridine, and a halogenated pyridine is coupled with a suitable nitrogen-containing, oxygen-containing ligand and a metal catalyst to form a carbon-nitrogen bond. Subsequently, an oxazole ring is formed through a cyclization reaction. In this process, halopyridine reacts with (S) -4-phenyl-4,5-dihydrooxazole-2-yl related nucleophiles, and controls the reaction conditions, such as temperature, solvent and catalyst type, in order to achieve high selectivity.
Second, starting from the construction of the oxazole ring, the fragment containing (S) -4-phenyl-4,5-dihydrooxazole-2-yl is first synthesized, and then it is connected to the pyridine derivative. Chiral sources can be used to synthesize (S) -4 -phenyl-4,5 -dihydrooxazole-2 -yl fragments, and then condensate with pyridine derivatives under appropriate reaction conditions. For example, by suitable dehydrating agents to promote the condensation between the two, forming a carbon-nitrogen bond, thereby obtaining the target product.
Third, the method of transition metal catalysis is used to catalyze the reaction between substrates with suitable metal catalysts, such as palladium, copper, etc. Under the action of metal catalysts, ligands and bases, the cross-coupling reaction occurs between the substrate containing pyridine structure and the substrate containing (S) -4-phenyl-4,5-dihydrooxazole-2-yl. By adjusting the structure of catalysts, ligands and reaction conditions, the activity and selectivity of the reaction are optimized to achieve efficient synthesis of 2,6-bis (S) -4-phenyl-4,5-dihydrooxazole-2-yl) pyridine. This method requires precise control of reaction conditions to obtain ideal yield and purity.
What are the physicochemical properties of 2,6-Bis ((S) -4-phenyl-4,5-dihydrooxazol-2-yl) pyridine
2% 2C6 - Bis% 28% 28S% 29 - 4 - phenyl - 4% 2C5 - dihydrooxazol - 2 - yl% 29pyridine, Chinese name or 2,6 - bis (S) -4 - phenyl - 4,5 - dihydrooxazole - 2 - yl) pyridine. The physical and chemical properties of this substance are as follows:
Its properties are either solid, mostly in powder form, and its color may be close to white to light yellow. This is due to its relatively regular molecular structure and stable crystal form. The melting point of
is an important physical constant. It is measured experimentally and is about a specific temperature range. This is the result of the joint action of intermolecular forces and lattice energy. Due to the aromatic ring and heterocyclic structure in the molecule, the intermolecular π-π stacking effect is enhanced, and the melting point is higher. In terms of solubility,
shows certain solubility in organic solvents such as dichloromethane, chloroform, toluene, etc. Because these solvents have similar intermolecular forces with the compound, they follow the principle of "similar phase dissolution". In water, the solubility is poor, because the polar molecules are relatively weak, and it is difficult to form effective interactions with water molecules. In terms of chemical properties, the pyridine ring and oxazole ring in its structure give unique reactivity. The nitrogen atom in the pyridine ring has a solitary pair of electrons, which can be used as a nucleophilic reagent to participate in the reaction or coordinate with metal ions to form a complex. The nitrogen and oxygen atoms in the oxazole ring also affect the distribution of its electron cloud, so that the neighboring carbon atoms have a certain electrophilicity and can participate in nucleophilic substitution and other reactions. And aromatic rings can undergo common aromatic electrophilic substitution reactions, such as halogenation, nitrification, etc., providing various possibilities for their chemical modification.
What is the market price of 2,6-Bis ((S) -4-phenyl-4,5-dihydrooxazol-2-yl) pyridine
I think what you are asking is about the market price of 2,6-bis ((S) -4-phenyl-4,5-dihydrooxazole-2-yl) pyridine. However, the price of this chemical often changes due to multiple reasons.
First, the purity of the product involved is the key. If the purity is very high, it is almost perfect, and its price is high; if the purity is slightly less, the price will also drop. High-purity products are difficult to prepare and require exquisite craftsmanship and complicated processes, so they are valuable.
Second, the supply channel also affects the price. If through reliable and large-scale suppliers, the quantity is sufficient and the quality is stable, and the price may be moderate; if the channel is narrow and the supply is unstable, the price is easy to fluctuate, or even high.
Third, the state of market demand cannot be ignored. If there is strong demand for this product in many industries, such as pharmaceutical research and development, fine chemical synthesis and other fields, the supply is in short supply, and the price will rise; on the contrary, the demand is weak, and the price will also decline.
As for the exact price, it is difficult to determine in the current market. If you want to know the details, you can consult the chemical product trading platform, professional chemical suppliers, or communicate with industry experts to get a precise price. It is necessary not to judge the price based on one end alone, but to comprehensively consider all factors before it is an appropriate policy.