2,6-bis((4R)-(+)-isopropyl-2-oxazolin-2-yl)pyridine

2%2C6-bis%28%284R%29-%28%2B%29-isopropyl-2-oxazolin-2-yl%29pyridine, the Chinese name is often called 2,6-bis ((4R) - (+) -isopropyl-2-oxazoline-2-yl) pyridine. The main application fields of this compound are as follows.
In the field of catalysis, it is often used as a ligand. Due to its unique spatial structure and electronic properties, it can closely complex with metal ions to form a high-efficiency catalyst. In asymmetric catalytic reactions, it is particularly remarkable. For example, in asymmetric hydrogenation reactions, it complexes with metals such as rhodium and ruthenium, which can perform asymmetric hydrogenation of substrates containing carbon-carbon double bonds, carbon-nitrogen double bonds, etc., and efficiently obtain chiral products. It provides a key technology for the preparation of chiral drug intermediates in the pharmaceutical industry. In the field of olefin polymerization catalysis, when combined with transition metals, it can precisely control the polymer microstructure and molecular weight distribution, and help to synthesize polyolefin materials with specific properties.
In the field of materials science, it also has applications. Because it can be complexed with metal ions, it can participate in the preparation of metal organic framework materials (MOFs). Such materials have a high specific surface area and a regular pore structure, and are excellent in gas adsorption and separation, such as the adsorption and separation of carbon dioxide, hydrogen and other gases. In addition, when preparing functional polymer materials, it can be used as a functional monomer or cross-linking agent to endow the material with special properties, such as the introduction of chiral structures, so that the material has the ability to recognize chirality. < Br >
In the field of chemical analysis, with its special ability to complex metal ions, it can act as a chemical analysis reagent. It is used to detect and quantitatively analyze specific metal ions. It can achieve sensitive detection of metal ions by complexing with metal ions to produce color changes and fluorescence signal changes. It plays an important role in environmental monitoring, biological analysis, etc.

To prepare 2,6-bis ((4R) - (+) -isopropyl-2-oxazoline-2-yl) pyridine, there are several common synthesis methods.
One is to use pyridine as the starting material, introduce a suitable leaving group first at the 2,6-position of pyridine, and then carry out nucleophilic substitution with (4R) - (+) -isopropyl-2-oxazoline. This process requires attention to the control of reaction conditions, such as temperature, solvent and base selection. If the temperature is too high or too low, both the reaction rate and the selectivity of the product may be affected; the appropriate solvent has a great influence on the solubility and reactivity of the reactants; the strength and dosage of the base are also related to the process of the reaction. If the base is too strong or causes side reactions, if it is too weak, it cannot effectively promote the reaction.
Second, consider the strategy of constructing a pyridine ring. First prepare an intermediate containing (4R) - (+) -isopropyl-2-oxazoline fragments, and then form a pyridine ring through cyclization reaction. In this synthesis path, the cyclization reaction conditions are the key. Different cyclization reagents and reaction conditions can lead to different cyclization methods and yields.
Third, metal-catalyzed coupling reactions are also a feasible approach. Suitable metal catalysts, such as palladium and nickel, catalyze the coupling of halogenated compounds containing (4R) - (+) -isopropyl-2-oxazoline groups with pyridine derivatives. The activity of metal catalysts, the structure of ligands, and the additives in the reaction system all have a profound impact on the success or efficiency of the reaction. The ligand can adjust the electron cloud density and steric resistance of the metal center, thereby affecting the catalytic activity and selectivity; additives may promote the stability of the catalyst or change the kinetics of the reaction.
All synthetic methods have their own advantages and disadvantages, and the choice needs to be weighed according to the actual situation, such as the availability of raw materials, cost, and purity requirements of the target product.

2%2C6-bis%28%284R%29-%28%2B%29-isopropyl-2-oxazolin-2-yl%29pyridine, this is an organic compound. Its physical and chemical properties are of great research value.
Looking at its physical properties, under room temperature and pressure, it is mostly in a solid state. Due to the strong intermolecular forces, the molecules are arranged in an orderly manner. In terms of melting point, or in a specific temperature range, the exact value of this temperature range is related to the degree of closeness of the molecular structure. In the structure, the pyridine ring is connected to two oxazoline rings containing chiral centers. The chiral center gives it a unique spatial configuration. This configuration has a great influence on the interaction between molecules, which in turn affects the melting point.
On solubility, in organic solvents, or exhibits some solubility. Due to the fact that the molecule has both polar and non-polar parts, the pyridine ring has a certain polarity, and the isopropyl group is a non-polar group, so it may have better dissolution performance in organic solvents with moderate polarity and non-polarity such as dichloromethane and chloroform. However, in water, its overall polarity is not enough to form a strong interaction with water molecules, and its solubility is poor.
In addition to chemical properties, the nitrogen atom of the pyridine ring has a lone pair of electrons, making it alkaline and can react with acids to form corresponding salts. The carbonyl groups on the two oxazoline rings are electrophilic and can participate in reactions such as nucleophilic addition. The existence of chiral centers makes them have great application potential in the field of asymmetric synthesis, which can be used as chiral ligands to coordinate with metal ions, catalyze asymmetric reactions, and selectively generate products of specific configurations. Its unique structure makes the compound play an important role in organic synthesis, medicinal chemistry and other fields, providing new opportunities and directions for the research and development of related fields.

There is a question today, what is the price of 2,6-bis ((4R ） - （ + ） - isopropyl-2-oxazoline-2-yl) pyridine in the market. This question wants to know what the value of this chemical product is in the market.
However, I have checked the past "Tiangong Kaiwu", but I have not found this product. The records in "Tiangong Kaiwu" are mostly common processes and products in the world at that time. When the book was written, the research of chemical products was not as prosperous as it is today. Such finely synthesized pyridine derivatives may not have been available at that time.
In today's world, science and technology are changing with each passing day, and the research in the field of chemistry is also advancing rapidly. If you want to know the price of this product, you should look for it in today's chemical market and chemical reagent transactions. Or you can ask chemical merchants and reagent suppliers, who are often involved in this product transaction and will be able to tell the price. Or you can visit the online chemical product trading platform, which also has the prices of various chemicals, and you can get the approximate search. However, due to the frequent changes in market conditions, the price also varies with supply and demand, origin, quality, etc., it is difficult to hide the exact price.

2%2C6-bis%28%284R%29-%28%2B%29-isopropyl-2-oxazolin-2-yl%29pyridine is an organic compound and its stability is very important.
The stability of this compound is related to many factors. From a structural point of view, the structure of the pyridine ring and the oxazoline structures on both sides affect each other. The electron cloud distribution of the pyridine ring is changed by the substitution of oxazoline. The isopropyl group of oxazoline has a certain steric barrier, which can affect the interaction between molecules. Spatial barrier may prevent the excessive close proximity between molecules and improve the stability to a certain extent, but it may also reduce the stability due to space tension.
As far as electronic effects are concerned, the nitrogen and oxygen atoms of the oxazoline ring have certain electronegativity, which can have electron conjugation or induction effects with the pyridine ring. This may make the distribution of molecular electron clouds more uniform and enhance molecular stability. However, if the electronic effect causes excessive concentration of charge in a certain area within the molecule, or the stability may be reduced.
The external environment also has a significant impact on its stability. When the temperature increases, the thermal motion of the molecule intensifies, or the vibration of the chemical bond intensifies, causing the bond to break and reducing the stability. In an environment with high humidity, if the compound is sensitive to water, the water molecule may interact with the compound, or hydrolyze, or form a hydrate, which affects the stability.
Under light conditions, if the compound can absorb light of a specific wavelength and initiate a photochemical reaction, it will also change its chemical structure and cause damage to its stability. Different solvent environments, due to the different interactions between solvents and compounds, or dissolution exothermic, or solvation, also affect the stability. Polar solvents and non-polar solvents have different solubility and interactions, or stabilize or promote their decomposition.
Overall, the stability of 2%2C6-bis%28%284R%29-%28%2B%29-isopropyl-2-oxazolin-2-yl%29pyridine is not only restricted by the electronic and spatial effects of its own molecular structure, but also by external environmental factors such as temperature, humidity, light, and solvents.