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What is 2,5-Lutidine = 2,5-Dimethylpyridine?
2% 2C5-Lutidine is 2% 2C5-dimethylpyridine, which is a compound in the field of organic chemistry. It has a pyridine ring structure, with a methyl group attached at the 2nd and 5th positions.
This compound is colorless to light yellow liquid and has a special pyridine-like odor. It plays a key role in organic synthesis and is often used as a base reagent because its nitrogen atom can provide electron pairs to react with acids or electrophilic reagents.
In the field of pharmaceutical chemistry, 2% 2C5-dimethylpyridine is often used as an intermediate in the synthesis of drugs. Because of its structure, it can be modified to help build a variety of bioactive molecules. In the field of materials science, it can participate in the preparation of functional materials, such as conductive polymers.
From the perspective of physical properties, 2% 2C5-dimethylpyridine has a lower density than water and is well miscible with most organic solvents. Its boiling point is about 157-158 ° C and its melting point is about -70 ° C.
Due to its chemical structure, 2% 2C5-dimethylpyridine has certain alkalinity and nucleophilicity. In chemical reactions, it can participate in nucleophilic substitution, nucleophilic addition and other reactions, creating rich possibilities for organic synthesis. It is widely used in modern chemical industry and scientific research.
What are the main uses of 2,5-Lutidine = 2,5-Dimethylpyridine?
2% 2C5-Lutidine is 2% 2C5-dimethylpyridine, which has a wide range of main uses. In the field of organic synthesis, it is often used as a reaction solvent. Because of its alkalinity, it can capture the acid generated by the reaction and promote the reaction to proceed in the forward direction. In many reactions that require a mild alkaline environment, such as acylation reactions, alkylation reactions, etc., it can be used as an ideal solvent to help the reaction occur smoothly.
Furthermore, in the field of medicinal chemistry, 2% 2C5-dimethylpyridine also plays an important role. In many drug synthesis processes, it can be used as a key intermediate. Through its special molecular structure, it can be converted into compounds with specific pharmacological activities through a series of chemical reactions, making great contributions to the development of new drugs. < Br >
In the field of materials science, it can be used to prepare specific functional materials. For example, in the synthesis of some polymer materials, the addition of 2% 2C5-dimethylpyridine can adjust the reaction rate and product structure, thereby giving the material unique properties, such as improving the solubility and thermal stability of the material.
In addition, in analytical chemistry, it can also be used as a reagent. With its special reaction or complexation ability to certain substances, it is used to detect, isolate and quantitatively analyze specific compounds, helping to accurately determine the composition and content of substances.
In conclusion, 2% 2C5-dimethylpyridine plays an indispensable role in many fields such as organic synthesis, medicine, materials and analytical chemistry, and is of great significance in promoting the development of related fields.
What are the physical properties of 2,5-Lutidine = 2,5-Dimethylpyridine?
2% 2C5-Lutidine is 2% 2C5-dimethylpyridine. Its physical properties are as follows:
2% 2C5-dimethylpyridine is a colorless to pale yellow liquid with an irritating odor. The boiling point is about 159 ° C. At this temperature, the molecule obtains enough energy to overcome the intermolecular forces to vaporize. The melting point is about -18 ° C. Below this temperature, the molecular arrangement changes from a disordered liquid state to an ordered solid state. The relative density is about 0.92 g/cm ³, indicating that it is slightly lighter than water at the same volume.
2% 2C5-dimethylpyridine is slightly soluble in water, because the nitrogen atom of the pyridine ring can form hydrogen bonds with water molecules, but the presence of dimethyl groups limits its degree of interaction with water. It is soluble in organic solvents such as ethanol and ether. Due to the principle of similar miscibility, it is similar to the intermolecular force of organic solvents and can be miscible with each other.
In addition, 2% 2C5-dimethylpyridine is stable at room temperature and pressure, but it is flammable in case of open flame and hot topic, and will react violently in contact with oxidants. Its vapor is heavier than air and can spread to a considerable distance at a lower place. In case of fire, it will catch fire and backfire.
What are the chemical properties of 2,5-Lutidine = 2,5-Dimethylpyridine?
2% 2C5-Lutidine is 2% 2C5-dimethylpyridine. This substance is alkaline. Because the nitrogen atom of the pyridine ring contains lone pairs of electrons and can accept protons, it can form salts in acids. It has aromatic properties. It is derived from the fact that the pyridine ring satisfies the Shocker rule. It has a cyclic, conjugated and 4n + 2 π electrons structure. It is stable in nature, difficult to add, and easy to electrophilic substitution.
2% 2C5-dimethylpyridine methyl group is active and can be oxidized under specific conditions. In case of strong oxidants, it can be converted to carboxyl groups. It can also participate in alkylation reactions, and the hydrogen of methyl groups can be replaced by other groups.
In the field of organic synthesis, 2% 2C5-dimethylpyridine is often used as a base to promote the reaction, or as a ligand to complex with metal ions to stabilize metal catalysts and promote catalytic reactions. Its solubility is good, and it is soluble in common organic solvents such as ethanol, ether, and benzene. This property is convenient for its use in various reaction systems. However, it has certain toxicity and irritation. When using, pay attention to protection, operate in good ventilation, and avoid contact with skin and inhalation.
What are the preparation methods of 2,5-Lutidine = 2,5-Dimethylpyridine?
2% 2C5-Lutidine is 2% 2C5-dimethylpyridine. The common preparation methods are as follows:
One is to use 2-methyl-5-ethylpyridine as raw material, under the action of suitable catalyst, through dehydrogenation reaction. This reaction requires a highly active and selective catalyst to promote the dehydrogenation and oxidation of ethyl group under specific temperature and pressure conditions, and then convert it to methyl group, thereby generating 2% 2C5-dimethylpyridine. During operation, it is extremely critical to control the reaction conditions. Too high or too low temperature may affect the yield and purity of the product.
The second is to use pyridine and methylation reagents as starting materials. Commonly used methylating reagents such as iodomethane, dimethyl sulfate, etc. In the alkaline environment, the nitrogen atom of pyridine has strong ability to obtain electrons, and it is easy to undergo nucleophilic substitution reaction with methylating reagents. Methyl groups are introduced into the 2 and 5 positions of the pyridine ring to obtain the target product. In this process, factors such as the type and dosage of bases, reaction time and temperature have a great influence on the reaction process and product distribution, and need to be carefully regulated.
The third is prepared by a series of complex reactions using furfural and ammonia as raw materials. Furfural first undergoes a condensation reaction with ammonia to form a nitrogen-containing intermediate, and then the intermediate undergoes multiple reactions such as hydrogenation, cyclization, and methylation, and finally generates 2% 2C5-dimethylpyridine. This route involves many reaction steps, complicated processes, and a wide range of raw materials. If the reaction conditions can be optimized, it also has great potential for industrial application.
The above preparation methods have their own advantages and disadvantages. In practical applications, it is necessary to comprehensively consider the availability of raw materials, production costs, product quality requirements and many other factors, and make a prudent choice.