2 5 Difluoropyridine
pyridine pyrrole pyrazine piperidine piperazine

2,5-difluoropyridine

    Specifications

    HS Code

    259119

    Chemical Formula C5H3F2N
    Molar Mass 113.08 g/mol
    Appearance Colorless to light yellow liquid
    Boiling Point 134 - 136 °C
    Density 1.29 g/cm³
    Solubility In Water Insoluble
    Flash Point 34 °C
    Refractive Index 1.454 - 1.456

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    General Information
    Where to Buy 2,5-difluoropyridine in China?
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    Frequently Asked Questions

    As a leading 2,5-difluoropyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2,5-difluoropyridine?
    2,5-Diethoxyanisole, its main uses are as follows:
    This is an important organic compound in the field of pharmaceutical synthesis, with a wide range of uses. It can be used as a key intermediate for the preparation of many drugs. For example, in the synthesis of some compounds with specific physiological activities, it is used as a starting material and goes through a series of delicate chemical reactions to finally construct drug molecules with therapeutic effects. Due to its unique chemical structure, it can impart specific properties and activities to drugs, which plays a crucial role in the efficacy of drugs.
    In the fragrance industry, 2,5-diethoxyanisole also has significant uses. With its unique odor, it can be used as one of the fragrance ingredients. After skillfully blending, it is integrated into various fragrance formulas to add a different aroma level and charm to the fragrance. Whether it is used to prepare daily flavors, such as perfumes, air fresheners, etc., or applied to the field of food flavors, it can play a unique role in making the aroma of the product more pleasant and unique, satisfying people's pursuit of different aromas.
    In the study of organic synthetic chemistry, it is also an indispensable reagent. Chemists often use its specific reactivity and structural characteristics to carry out various novel organic reaction exploration and research. Through functional group transformation, molecular modification and other operations, the structural diversity of organic compounds is expanded, providing the possibility for the discovery of new chemical substances and reaction paths, and promoting the continuous development and progress of the field of organic synthetic chemistry.
    What are the synthesis methods of 2,5-difluoropyridine?
    The synthesis methods of 2% 2C5-diethoxypyrimidine vary widely, relying on various chemical techniques and ingenuity.
    First, it can be obtained by the reaction of the corresponding pyrimidine derivative with halogenated ethane under the catalysis of alkali. Among them, the pyrimidine derivative needs to be finely prepared, and the halogenated ethane also needs to be pure. During the reaction, the amount of base, reaction temperature and duration must be precisely controlled. Too much or too little alkali may cause reaction errors; too high or too low temperature will also affect the formation of the product. If the duration is improper, or the reaction is not completed, or the product decomposes. For example, pyrimidine is used as the starting material, and its specific position is first activated, and then it is heated and refluxed in a suitable organic solvent with bromoethane under the action of a base such as potassium carbonate, or the target product can be obtained.
    Second, the pyrimidine ring is synthesized by the construction reaction of the pyrimidine ring. First, the pyrimidine ring is constructed by a multi-step reaction with suitable nitrogen and oxygen-containing compounds as raw materials, and ethoxy groups are introduced at the same time. This approach requires careful design of each step of the reaction to ensure the selectivity and yield of the reaction. The choice of starting materials is crucial, and the convenience of reactivity and subsequent introduction of functional groups must be taken into account. For example, some compounds containing carbonyl and amino groups are used as the starting point, condensed and cyclized under specific conditions, and then ethoxylated to achieve the purpose of synthesis
    Third, metal-catalyzed coupling reactions can also be used. The unique activity of metal catalysts is used to promote the coupling of pyrimidine-containing substrates with ethoxylation reagents. This method requires the selection of suitable metal catalysts, such as palladium, copper, etc., and their ligands. The combination of metals and ligands greatly affects the reaction efficiency and selectivity. And the reaction system needs to be strictly anhydrous and oxygen-free to ensure the smooth progress of the reaction. For example, under palladium catalysis, halogenated pyrimidine and ethoxy borate ester undergo Suzuki coupling reaction. After careful post-treatment, 2% 2C5-diethoxy pyrimidine can be obtained.
    All kinds of synthesis methods have their own advantages and disadvantages, and they need to be carefully selected according to the actual situation, such as the availability of raw materials, cost considerations, product purity requirements, etc., in order to achieve the purpose of synthesis.
    What is the market price of 2,5-difluoropyridine?
    In today's world, the price of 2,5-diethoxybenzene in the market depends on a variety of reasons. The fluctuation of its price is either related to the abundance of the material, or depends on the difficulty of production, or depends on the amount of need.
    If the material is easy to purchase and abundant, the method of production is simple and cost-effective, and there are few people in the world who use it, the price may be inexpensive. If the material is easy to obtain, it is not difficult to make, and there are few applicants, the merchant will reduce the price to attract customers in order to sell his goods quickly.
    On the contrary, if the material is rare, difficult to find, and the technology of production is complicated and expensive, and there are many users, the price will be high. Materials are scarce, procurement costs a lot of money, production is laborious, and people compete for purchases. Merchants will raise their prices because they are rare and expensive.
    And the market is fickle, and all kinds of current events can affect their prices. If the four-way trade routes are smooth, the flow of goods is unobstructed, and the price is stable; if there are soldiers, disasters, and trade routes are obstructed, and the goods cannot be reached, the price will rise.
    There is also the art of making. If the new art is passed on, it can save materials and time, and the price may drop; if the art is old-fashioned, it is difficult to improve, and the cost is high, the price will be difficult to lower.
    As for the needs of users, it is also a major reason. If an industry is prosperous, the demand for 2,5-diethoxybenzene will increase sharply, and the supply will exceed the demand, and its price will rise; if the industry is sluggish, the demand will be few, and the price will also fall.
    Therefore, in order to know the market price of 2,5-diethoxybenzene, it is necessary to carefully examine the materials, production, needs, and various world conditions in order to obtain its approximation.
    What are the physical and chemical properties of 2,5-difluoropyridine?
    2% 2C5-diethoxythiophene is an organic compound. Its physical and chemical properties are unique and can be investigated.
    In terms of physical properties, this substance is mostly liquid under normal conditions, with specific color, taste and volatility. Its color may be colorless to slightly yellow, and the quality is clear. The taste may have a special aromatic aroma, but it is not strong and pungent. In terms of volatility, it has a certain volatilization rate under normal temperature and pressure, which is determined by intermolecular forces.
    In terms of solubility, 2% 2C5-diethoxythiophene exhibits good solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc., which can be miscible with it. However, in water, its solubility is poor, and because its molecular structure contains more non-polar groups, the force between it and water molecules is weak.
    As for chemical properties, the thiophene ring structure of 2% 2C5-diethoxy thiophene makes it have certain aromatic and electron cloud distribution characteristics. This structure allows it to participate in many chemical reactions, such as electrophilic substitution reactions. Because the electron cloud density on the thiophene ring is high, it is vulnerable to electrophilic attack. And the presence of its ethoxy group also affects the reactivity and selectivity. Ethoxy groups can regulate the electron cloud density distribution on the thiophene ring through induction and conjugation effects, thereby affecting the position and rate of electrophilic substitution reactions. At the same time, 2% 2C5-diethoxythiophene may undergo oxidation, reduction and other reactions under appropriate conditions. The specific reaction path and product depend on the reaction environment and the reagents used.
    What are the precautions for storing and transporting 2,5-difluoropyridine?
    2% 2C5-divinylbenzene requires careful attention during storage and transportation.
    When storing, choose the first environment. It should be placed in a cool and ventilated place, away from fire and heat sources. Because 2% 2C5-divinylbenzene is flammable, high temperature or open flame is easily dangerous. And should be stored separately from oxidants, acids, etc., must not be mixed to prevent chemical reactions. This substance is quite sensitive to humidity, humid environment or deterioration of quality, so the humidity in the warehouse should be properly controlled.
    Furthermore, the packaging should be rigorous. Be sure to ensure that the packaging is intact to avoid material leakage. When the packaging material meets the relevant standards, it has good sealing and corrosion resistance, which can effectively prevent the influence of external factors on 2% 2C5-divinylbenzene.
    During transportation, there are also many points. Transportation vehicles must be equipped with corresponding fire equipment and leakage emergency treatment equipment. Drivers and escorts should be professionally trained and familiar with the characteristics of 2% 2C5-divinylbenzene and emergency treatment methods. When driving, the speed should not be too fast to prevent sudden braking to avoid package damage caused by collisions and vibrations. Transportation routes should avoid densely populated areas and traffic congestion areas to reduce the hazards in the event of accidents.
    The loading and unloading process also requires extra care. The operation should be light and light, and it is strictly forbidden to drop and heavy pressure to prevent the leakage of materials caused by damaged packaging. If there is a leak at the loading and unloading site, the emergency plan should be activated immediately, the surrounding personnel should be evacuated, and effective measures should be taken to collect and deal with the leakage to prevent environmental pollution and safety accidents.
    In this way, when storing and transporting 2% 2C5-divinylbenzene, pay full attention to the above things to ensure its safety and stability to the greatest extent.