2 5 Dibromo 6 Methylpyridine
pyridine pyrrole pyrazine piperidine piperazine

2,5-dibromo-6-methylpyridine

    Specifications

    HS Code

    548365

    Name 2,5 - dibromo - 6 - methylpyridine
    Molecularformula C6H5Br2N
    Molarmass 250.92 g/mol
    Appearance Solid (usually)
    Color Off - white to pale yellow
    Boilingpoint Around 257 - 259 °C
    Meltingpoint Around 49 - 51 °C
    Solubilityinwater Insoluble
    Solubilityinorganicsolvents Soluble in common organic solvents like dichloromethane, chloroform

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    General Information
    Where to Buy 2,5-dibromo-6-methylpyridine in China?
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    Frequently Asked Questions

    As a leading 2,5-dibromo-6-methylpyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2,5-dibromo-6-methylpyridine?
    2% 2C5-dibromo-6-methylpyridine is a crucial intermediate in organic synthesis. Its role is particularly significant in the field of medicinal chemistry. Many drugs are created with 2% 2C5-dibromo-6-methylpyridine as the starting material. Through a series of delicate chemical reactions, specific functional groups are added, and then molecular structures with unique pharmacological activities are established. For example, in the synthesis of some antibacterial drugs, 2% 2C5-dibromo-6-methylpyridine can be used as a key building block, cleverly spliced with other nitrogen-containing and oxygen-containing heterocyclic compounds to construct new compounds that have inhibitory effects on bacterial cell wall synthesis or protein synthesis, thus exerting antibacterial efficacy.
    In the field of materials science, 2% 2C5-dibromo-6-methylpyridine also has important uses. It can participate in the synthesis of conductive polymers or optically active materials. By carefully designing the reaction conditions to polymerize with conjugated monomers, new materials with special electrical or optical properties can be prepared. Like in the development of organic Light Emitting Diode (OLED) materials, such pyridine derivatives can introduce unique electron cloud distribution and conjugate structure, improve the luminous efficiency and stability of the material, and help to achieve higher resolution and better color performance of the display screen.
    Furthermore, in pesticide chemistry, 2% 2C5-dibromo-6-methyl pyridine can be used to synthesize pesticides with high insecticidal, bactericidal or herbicidal activities. Its special chemical structure can precisely bind to specific biological targets in pests, pathogens or weeds, interfering with their normal physiological metabolic processes, and achieving the purpose of preventing and controlling pests. For example, for some pests that are resistant to traditional pesticides, new pesticides developed based on 2% 2C5-dibromo-6-methylpyridine may regain good control effects with novel mechanisms of action.
    What are the synthesis methods of 2,5-dibromo-6-methylpyridine?
    The synthesis method of 2% 2C5-dibromo-6-methylpyridine has existed in ancient times and is described in detail below.
    First, pyridine is used as the starting material, and methyl is introduced through methylation reaction. It can be added to a suitable solvent, such as toluene, with pyridine and methylating reagents, such as iodomethane, and an appropriate amount of base, such as potassium carbonate, to promote the reaction. Heat and reflux to allow the reaction to proceed fully. After this step, 6-methylpyridine can be obtained. Then, 6-methylpyridine is dissolved in a halogenated solvent, such as dichloromethane, and a brominating agent, such as bromine or N-bromosuccinimide (NBS), is added dropwise at low temperature to control the reaction conditions, so that the bromine atom selectively replaces the hydrogen atom at the 2,5 position, and then 2,5-dibromo-6-methylpyridine is obtained. This method step is clear, but attention should be paid to the precise control of the reaction conditions, otherwise it is prone to side reactions.
    Second, 2-bromo-6-methylpyridine is used as the raw material. In the reaction system, a suitable catalyst, such as a copper salt catalyst, and a ligand, such as o-phenanthroline, are added. Then a brominating reagent is added to react at a suitable temperature and solvent environment. This process requires fine adjustment of the reaction temperature, time and material ratio, so that the bromine atom can be successfully replaced at the 5 position to synthesize the target product. This method requires high purity of raw materials, but proper operation results in higher yields.
    Third, 5-bromo-6-methylpyridine-2-borate is used as the starting material. React it with a brominating reagent under basic conditions, and common basic reagents such as sodium carbonate aqueous solution. The reaction is carried out in a mixed system of organic solvent and water within a certain temperature range. By optimizing the reaction parameters, the conversion to 2,5-dibromo-6-methylpyridine can be effectively realized. This method has relatively mild conditions and does not require high equipment, but the cost of raw materials may become a limiting factor.
    All kinds of synthesis methods have advantages and disadvantages. It is necessary to choose carefully according to actual needs, such as raw material availability, cost considerations, yield requirements, etc., in order to make the synthesis process smooth and achieve the expected effect.
    What are the physical properties of 2,5-dibromo-6-methylpyridine?
    2% 2C5-dibromo-6-methylpyridine is an organic compound. Its physical properties are as follows:
    In terms of appearance, it is mostly solid at room temperature, and the color is often white to light yellow. Those who are pure have a lighter color and may be darker when they contain impurities. This affects the reflection and absorption of light due to molecular structure and impurities.
    On the melting point, it is about a specific temperature range. The specific value varies depending on the purity. Generally, it is accurately determined by experiments. This property is used for identification and purification, and can be compared with the standard melting point to judge the purity.
    The boiling point also has a corresponding range. At this temperature, the liquid state is converted into a gaseous state, which is of great significance for separation and purification. According to the difference in boiling point, it is separated from the mixture by distillation. < Br > In terms of solubility, it has a certain solubility in organic solvents such as ethanol, ether, and chloroform. Due to the principle of similar miscibility, its organic structure has a similar polarity to that of organic solvents; in water, the solubility is low, and due to the strong polarity of water, it is very different from the structure of the compound.
    Density has a specific value relative to water, which is related to its stratification position in liquid mixtures, and is important for separation operations in experimental and industrial applications.
    Odor may have a weak special smell, but your mileage may vary, and the odor perception is different at different concentrations. These physical properties are of great significance in the fields of chemical research, drug synthesis, material preparation, etc., and researchers perform synthesis, separation, and identification operations accordingly.
    What is the market price of 2,5-dibromo-6-methylpyridine?
    Wen Jun inquired about the market price of 2,5-dichloro-6-methylpyridine. This product is in the market, and the change in its price is related to many ends.
    First, the price of raw materials is the main reason. If the price of all raw materials used in the synthesis of this pyridine increases, the production of 2,5-dichloro-6-methylpyridine will increase, and the price will also increase. On the contrary, the price of raw materials decreases, and the cost also decreases, and the price may fall.
    Second, the clumsiness of the process is also related to its price. Sophisticated craftsmanship can improve the yield, reduce energy consumption, and control the cost. The price may be stable or reduced. If the process is crude, the yield is low and the energy consumption is high, the price will be high.
    Furthermore, the supply and demand of the market is the pivot of the price. If there are many people who want it, but the supply is small, the price will rise. If there are many producers and few people who want it, the stock of goods is in the market, and the price will fall.
    And different merchants in the city have different prices. Large merchants or with their wide regulations and smooth channels, the price may be more stable and appropriate; small merchants or because of the small quantity and high cost, the price may be slightly higher.
    In general, the market price of 2,5-dichloro-6-methylpyridine often changes in the market, or fluctuates up and down due to raw materials, processes, supply and demand. To know the real-time price, you should check the market situation carefully and consult the merchants to get the exact number.
    What are the precautions for storing and transporting 2,5-dibromo-6-methylpyridine?
    2% 2C5-dibromo-6-methylpyridine is a kind of organic compound. During storage and transportation, many matters must be paid attention to.
    When storing, the first choice of environment. It should be placed in a cool and ventilated warehouse, because the compound may be sensitive to heat, and high temperature may cause chemical changes or even cause danger. The temperature of the warehouse should not be too high, and the humidity should be properly controlled to prevent it from being deteriorated due to moisture.
    Furthermore, the storage place should be away from fire and heat sources. This compound may be flammable, and it is very easy to cause combustion or even explosion in case of open flame and hot topic, so fire prevention is very important. At the same time, it needs to be stored separately from oxidizing agents, acids, alkalis, etc., because different chemical substances are prone to chemical reactions. Once mixed, it may cause unpredictable consequences.
    When transporting, the packaging must be solid and reliable. Select appropriate packaging materials to ensure that the compound does not leak during transportation bumps. Transportation vehicles should also be equipped with corresponding fire equipment and leakage emergency treatment equipment to prevent leakage and other situations, and can be dealt with in time.
    During transportation, ensure that the container does not leak, collapse, fall, or damage. The route should be reasonably planned to avoid densely populated areas and busy traffic areas to avoid major hazards in the event of an accident. And the transportation process must strictly abide by relevant laws and regulations and operating procedures to ensure the safety of transportation. In short, whether storing or transporting 2% 2C5-dibromo-6-methyl pyridine, safety should be the top priority, and every link should be treated with caution.