2-(4-tolyl)pyridine

2-% (4-toluene) pyridine, an organic compound. It has a wide range of uses and can play an important role in many fields.
In the field of organic synthesis, it is often used as a key intermediate. Through specific chemical reactions, it can be cleverly converted into organic molecules with more complex structures. For example, in the field of medicinal chemistry, a series of chemical modifications and derivatization of 2- (4-toluene) pyridine can prepare pharmaceutical molecules with specific pharmacological activities. Due to its unique chemical structure, it can interact with specific targets in organisms, thus demonstrating the efficacy of treating diseases.
In the field of materials science, 2- (4-toluene) pyridine also has important uses. It can participate in the preparation of luminescent materials. In organic electroluminescent devices (OLEDs), such compounds can be used as key components of luminescent layer materials, giving the device good luminescent properties, such as high brightness and high purity color. Because the molecular structure can affect the behavior of electron transitions in the luminescence process, it is of great significance in new display technologies.
In addition, in the field of catalysis, 2- (4-toluene) pyridine can sometimes act as a ligand. After combining with metal ions to form complexes, it can exhibit unique catalytic activity and selectivity. In some organic synthesis reactions, the complex can effectively catalyze the reaction, improve the reaction efficiency and product selectivity, and is of great value in industrial production and organic synthesis research. In short, 2- (4-toluene) pyridine, with its unique structure, plays an important role in organic synthesis, materials science, catalysis and other fields, and promotes the sustainable development and progress of related fields.

2-% (4-tolyl) pyridine, that is, 2- (4-methylphenyl) pyridine, can be synthesized by various methods, as follows:
** 1. Synthesis method using pyridine and p-methylhalobenzene as raw materials **
This synthesis route is based on pyridine and p-methylhalobenzene as starting materials. First take an appropriate amount of pyridine, place it properly in the reaction vessel, and add an appropriate amount of strong base, such as n-butyllithium. N-butyllithium is strongly basic and can capture the hydrogen atom at the 2-position of pyridine to generate a pyridine 2-position negative ion with strong nucleophilicity.
Subsequently, p-methylhalobenzene is slowly added to the reaction system. The halogen atom in this halobenzene has a certain electrophilicity due to the influence of the benzene ring. The nucleophilic pyridine 2-position negative ion quickly attacks the carbon atom connected to the halogen atom in p-methylhalobenzene, and the halogen atom leaves with a pair of electrons to form 2- (4-methylphenyl) pyridine. This reaction needs to be carried out in a harsh environment with low temperature and no water and no oxygen to prevent side reactions from occurring. Low temperature can effectively inhibit the formation of negative ions at other positions of pyridine, and anhydrous and anaerobic can avoid oxidation or hydrolysis of the reactants and products.
** II. Synthesis with the help of transition metal catalysis **
1. ** Palladium-catalyzed coupling reaction **: Using 2-halopyridine and p-methylphenylboronic acid as raw materials. First add 2-halopyridine, p-methylphenylboronic acid, palladium catalyst (such as tetra (triphenylphosphine) palladium), and base (such as potassium carbonate) into the reaction vessel in a specific ratio, and then add an appropriate amount of organic solvent, such as toluene or dioxane. The palladium catalyst can activate the carbon-halogen bond in 2-halopyridine, and the boron atom of p-methylphenylboronic acid can react with the base to form a nucleophilic intermediate. This intermediate attacks the activated carbon-halogen bond, and through a series of complex reactions, the carbon-carbon bond coupling is realized to form the target product 2- (4-methylphenyl) pyridine. This reaction condition is relatively mild, the yield is quite high, and the selectivity is also good.
2. ** Nickel Catalytic Coupling Reaction **: Using 2-halogenated pyridine and p-methylhalobenzene as raw materials, nickel catalysts (such as the catalytic system composed of nickel bromide and ligand) are used. Nickel catalysts can coordinate with reactants to reduce the activation energy of the reaction. In the reaction, the nickel catalyst interacts with the halogen atom in 2-halogenated pyridine to form an active intermediate, and then the methyl halobenzene is coupled with it to form 2- (4-methylphenyl) pyridine. The cost of nickel catalyst is lower than that of palladium catalyst, and it is also a promising synthesis method.
** III. Synthesis of 2-methylpyridine and p-methylbenzaldehyde as raw materials **
Mix 2-methylpyridine and p-methylbenzaldehyde in the reaction vessel, add an appropriate amount of catalyst, such as p-toluenesulfonic acid, under heating conditions, the methyl group of 2-methylpyridine is affected by the pyridine ring and has a certain acidity, which can condensate with p-methylbenzaldehyde. During the reaction, the hydrogen atom on the 2-methylpyridine methyl group combines with the aldehyde oxygen atom of p-methylbenzaldehyde to form water dehydration, and the two molecular reactants are connected to form an intermediate product. 2 - (4 -methylphenyl) pyridine can be obtained by dehydration and rearrangement of the intermediate product. The raw material of this method is easy to obtain, but the reaction steps are slightly complicated, and the reaction conditions need to be carefully controlled to improve the yield and purity.

2-% (4-tolyl) pyridine is an organic compound with unique physical properties. It is a solid at room temperature, and its melting and boiling point has a great influence on its morphology and application under different conditions. The melting point is about a certain temperature range, which makes it a solid-to-liquid transition at a certain temperature. During synthesis and separation, knowledge of the melting point helps to control the reaction conditions and product purity. The boiling point determines the temperature at which it converts from liquid to gas when heated, and is related to separation and purification operations such as distillation.
The appearance of the compound may be white or quasi-white crystalline, which is convenient for preliminary identification and judgment. Its solubility is also an important physical property. In organic solvents such as ethanol and ether, it may exhibit some solubility, but in water, it may be poorly soluble. This difference in solubility is of great significance in the extraction, separation and selection of reaction media of compounds, and suitable solvents can be selected according to their solubility characteristics to achieve specific reactions or separation goals. The density of
2-% (4-tolyl) pyridine is also a specific value. This property is crucial in operations involving mass and volume conversion. In chemical production and other fields, accurate knowledge of density is helpful for accurate calculation and ratio of material quantities. In addition, it has certain stability, but under specific conditions such as high temperature, strong acid and alkali environment, or chemical reaction, the structure is changed. The in-depth understanding of its physical properties lays a solid foundation for its application in many fields such as organic synthesis and materials science.

2-% (4-tolyl) pyridine is an organic compound with many unique chemical properties. Its structure contains a pyridine ring and a p-methylphenyl group, which endows it with a variety of chemical activities.
From the perspective of nucleophilic reactions, the nitrogen atom of the pyridine ring has a lone pair of electrons, is basic, and can react with electrophilic reagents. For example, when encountering halogenated hydrocarbons, the nitrogen atom nucleophilic attacks the carbon atom of the halogenated hydrocarbon to form quaternary ammonium salts. This reaction can be used in organic synthesis to form new carbon-nitrogen bonds and synthesize complex nitrogen-containing compounds. < Br >
In the electrophilic substitution reaction, due to the uneven electron cloud density of the pyridine ring, the electron-absorbing density of the nitrogen atom decreases the electron cloud density of its neighbor and para-site, and the meta-site is relatively high. The electrophilic substitution mostly occurs in the meta-site of the pyridine ring. However, the benzene ring part increases the electron cloud density of the benzene ring due to the power supply of methyl group, and the electrophilic substitution is more likely to occur in the o-site and para-site of the benzene ring. Like when reacting with brominating reagents, bromine atoms or substituted benzene ring o-site and para-site hydrogen atoms.
2-% (4-tolyl Its nitrogen atoms can coordinate with metal ions to form stable complexes. In coupling reactions such as palladium catalysis, this complex can effectively activate reaction substrates and promote the formation of carbon-carbon bonds and carbon-heteroatomic bonds. It is widely used in drug synthesis and materials science.
In addition, the compound has certain optical properties due to its conjugated system. It can absorb specific wavelengths of light and undergo electronic transitions. It may exhibit fluorescence emission properties in photophysical and photochemical processes, providing possibilities for its application in optical materials, such as preparing fluorescent probes for biological imaging to detect specific substances or processes in living organisms.

2-%284-tolyl%29pyridine is 2 - (4 - methylphenyl) pyridine, the price of this product in the market is difficult to determine.
First, the price of raw materials is the key. The preparation of 2 - (4 - methylphenyl) pyridine requires specific raw materials. If the price of raw materials fluctuates, the price of finished products will also change. If raw materials are scarce, the demand will exceed the supply, and the price will rise; on the contrary, if the raw materials are abundant, the supply will exceed the demand, and the price will fall.
Second, the preparation method is related to the cost. Different preparation methods require different costs. If an ingenious and efficient method is adopted, although the upfront investment may be large, it may reduce the cost in the long run, which is conducive to price stability. On the contrary, if the preparation method is crude, the cost is high, and the price is difficult to be close to the people.
Third, the market supply and demand shape the price. If the market has a large demand for 2 - (4 - methylphenyl) pyridine, but the supply is limited, the price will rise; if the demand is low and the supply is excessive, the merchant will sell its goods or reduce the price.
Fourth, the production scale also has an impact. In large-scale production, due to the scale effect, the unit cost may be reduced, and the price may be more competitive; in small-scale production, the cost may not be reduced, and the price may be higher. < Br >
There are also quality factors. For high quality, the price may be higher than that of ordinary products.
It can be seen from the above that the market price of 2- (4-methylphenyl) pyridine varies due to many factors such as raw materials, preparation, supply and demand, scale, and quality. To know the exact price, it is necessary to examine the current market situation in detail.