2-[(4-nitrobenzyl)sulfanyl]pyridine-3-carboxylic acid

This is the chemical structure analysis of 2- [ (4-nitrobenzyl) thio] pyridine-3-carboxylic acid. Looking at its name, its structure can be analyzed as follows:
The pyridine ring is its core structure, which is a nitrogen-containing six-membered heterocycle with aromatic properties. The second position of the pyridine ring is connected with a specific substituent, namely [ (4-nitrobenzyl) thio]. In this substituent, benzyl is benzyl, that is, benzene ring-linked methylene (-CH 2O -), while 4-nitrobenzyl indicates that the 4th position of the benzene ring is replaced by nitro (-NO 2O). Furthermore, the methylene of the benzyl group is connected to the 2nd position of the pyridine ring through a sulfur atom (-S -).
The 3rd position of the pyridine ring is connected with a carboxyl group (-COOH), which is a landmark functional group of carboxylic acids.
In summary, the chemical structure of 2- [ (4-nitrobenzyl) thio] pyridine-3-carboxylic acid is composed of pyridine ring as the group, [ (4-nitrobenzyl) thio] at position 2, and carboxyl at position 3. In this structure, the pyridine ring imparts its aromatic properties, the nitro group has strong electron absorption, which affects the distribution of molecular electron clouds and reactivity, and the carboxyl group makes the molecule acidic. It can participate in many acid-base reactions and esterification reactions, and the interaction of various parts determines the chemical properties and reaction behavior of the compound.

2 - [ (4-nitrobenzyl) thioalkyl] pyridine-3-carboxylic acid, is a kind of organic compound. Looking at its molecular structure, it contains pyridine rings, carboxyl groups and specific thioalkyl substituents. As far as the physical properties of this thing are concerned, let me tell you one by one.
First of all, its phase state is often solid at room temperature and pressure. Due to the existence of various forces between molecules, such as van der Waals force, hydrogen bonds, etc., the molecules are closely arranged, so they condense into a solid state. The shape and texture of this solid state may be crystalline, and the formation of the crystal form is closely related to the regularity of the molecular structure. The spatial arrangement of molecules is orderly, which prompts the formation of crystals.
As for the color, it is often white to light yellow. The reason for this color is the absorption and reflection characteristics of light by molecules. The chemical bonds and functional groups in the molecule absorb visible light of specific wavelengths, and the rest of the wavelengths are reflected. Under the combined action, it presents such a color range.
In terms of solubility, its solubility in water is quite limited. This is because although the molecule contains carboxyl groups and has a certain hydrophilicity, the pyridine ring and the thialkyl group are partially hydrophobic, and the combination of the two results in poor solubility in water. However, in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), the solubility is relatively good. The molecules of the organic solvent can form suitable interactions with the molecules of the compound, such as van der Waals forces, dipole-dipole interactions, etc., which promote the occurrence of the dissolution process.
Melting point is also an important physical property. Experiments have determined that its melting point is in a certain temperature range. The melting point depends on the strength of the intermolecular forces. The stronger the intermolecular forces, the higher the energy required to make the molecule break free from the lattice and change from solid to liquid, and the melting point also increases. The various forces between the molecules of the compound jointly determine its melting point value, which is of great significance for the identification and purification of the substance.
In addition, the density of the compound is also a specific value. Density reflects the mass per unit volume of a substance, and is related to the relative mass of molecules and the degree of molecular packing. Its molecular structure is determined, the relative mass is certain, and the molecular packing method determines the density. This density characteristic may have certain reference value in practical application scenarios such as chemical production and material separation.
In summary, the physical properties of 2 - [ (4-nitrobenzyl) thioalkyl] pyridine-3-carboxylic acids are profoundly affected by their molecular structures, and their properties are related to each other, which has potential application value in many fields such as organic synthesis and materials science.

2-%5B%284-nitrobenzyl%29sulfanyl%5Dpyridine-3-carboxylic acid, Chinese name or 2- [ (4-nitrobenzyl) thio] pyridine-3-carboxylic acid. This compound has important uses in many fields such as medicine and chemical industry.
In the field of pharmaceutical research and development, it can be said to be a key drug introduction. Due to its specific chemical structure and activity, it can play a role in specific biological targets. For example, after in-depth research, it has been found that it may be able to bind to biological macromolecules such as proteins and enzymes related to certain diseases, thereby regulating their biological activities. As far as the development of anti-tumor drugs is concerned, the interaction with specific proteins in tumor cells can interfere with the growth, proliferation, metastasis and other key links of tumor cells, opening up a new path for the creation of anti-cancer drugs. Or it can regulate the molecules related to the human immune system, emerging in the research and development of immunomodulatory drugs, providing new ideas for the treatment of immune diseases.
In the chemical industry, this compound is like the key to the magic formula. It can be used as a key intermediate in organic synthesis. With its unique structure, through a series of chemical reactions, organic compounds with diverse structures and functions can be derived. For example, by reacting with different reagents such as substitution and addition, more complex organic molecular structures can be constructed, laying the foundation for the synthesis of fine chemical products such as high-performance materials, special dyes, fragrances, etc. In materials science, ingenious design and modification can endow materials with special properties, such as improving their optical, electrical, and thermal properties, thus promoting the development and application of new functional materials.

2-%5B%284-nitrobenzyl%29sulfanyl%5Dpyridine-3-carboxylic acid is 2- [ (4-nitrobenzyl) thio] pyridine - 3 - carboxylic acid, the synthesis method is as follows:
starting material can be selected pyridine - 3 - carboxylic acid and 4 - nitrobenzyl halide (such as 4 - nitrobenzyl chloride or 4 - nitrobenzyl bromide), both of which are readily available, laying the foundation for synthesis. In the
reaction process, the pyridine-3-carboxylic acid is properly activated first, and the condensing agent, such as dicyclohexyl carbodiimide (DCC) and 4-dimethylaminopyridine (DMAP) system, can be used in organic solvents (such as dichloromethane, N, N-dimethylformamide, etc.) to form an active intermediate of pyridine-3-carboxylic acid to enhance its nucleophilicity.
Subsequently, 4-nitrobenzyl halide is added, and the halogen atom has good departure properties. Under the action of the nucleophilic reagent in the system, the nucleophilic substitution reaction occurs with the active intermediate of pyridine-3-carboxylic acid. This reaction needs to be carried out at a suitable temperature, often in an ice bath or room temperature conditions, to ensure the smooth occurrence of the reaction and avoid excessive side reactions.
After the reaction is completed, the reaction mixture is treated. The organic solvent can be removed by means of vacuum distillation first, and then the product can be separated and purified by column chromatography or recrystallization. In column chromatography, a suitable silica gel is selected as the stationary phase, and the mixed solvent of petroleum ether and ethyl acetate is used as the mobile phase. Separation is achieved according to the difference in the partition coefficient between the product and the impurities in the stationary phase and the mobile phase. The recrystallization method is based on the solubility characteristics of the product in different solvents, and solvents such as ethanol and water are selected for recrystallization to finally obtain pure 2- [ (4-nitrobenzyl) thio] pyridine-3-carboxylic acid.
Another synthesis idea is to use 2-mercaptopyridine-3-carboxylic acid and 4-nitrobenzyl halide as raw materials. The thiol group in 2-mercaptopyridine-3-carboxylic acid has strong nucleophilicity. Under basic conditions (such as potassium carbonate, sodium hydroxide and other basic substances), in suitable organic solvents (such as acetonitrile, acetone, etc.), it can directly undergo nucleophilic substitution reaction with 4-nitrobenzyl halide to generate the target product. After the reaction, the subsequent processing steps are similar to the above method, and the high-purity product is obtained through separation and purification operations. In this way, the synthesis of 2- [ (4-nitrobenzyl) thio] pyridine-3-carboxylic acid can be realized through careful design and operation.

I have not been able to find exact information on the market price range of 2 - [ (4 - nitrobenzyl) sulfanyl] pyridine - 3 - carboxylic acid. This compound may be a relatively uncommon chemical, and its price is determined by many factors.
First, the manufacturer and the place of origin have a great influence on the price. Different manufacturers will have different prices due to different technical levels and production costs. If the place of origin is rich in raw materials and convenient transportation, the cost may be reduced, and the price will also vary.
Second, the purity is extremely critical. For high-purity compounds, the preparation is difficult and expensive, and the price will be high; for low-purity compounds, the price will be relatively low.
Third, the quantity purchased also affects the price. When purchasing in large quantities, the manufacturer may give a certain discount due to economies of scale, and the price is relatively favorable; if you buy a small amount, the unit price will be higher.
Fourth, the market supply and demand conditions also affect the price. If the market demand is strong and the supply is limited, the price may rise; conversely, when the supply exceeds the demand, the price may fall.
Due to the lack of specific market surveys and related data, it is difficult to determine the price range. For details, you can consult chemical product suppliers, chemical trading platforms, or consult relevant market reports, so that you can get more accurate price information.