2-(4-Methylphenyl)pyridine

2-% 284 - Methylphenyl%29pyridine is 2 - (4 - methylphenyl) pyridine, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Taking the preparation of heterocyclic compounds with specific structures as an example, through clever chemical reactions, it can interact with many reagents to form complex and novel heterocyclic systems. Such heterocyclic compounds are of great significance in the field of medicinal chemistry, and may become the cornerstone of the development of new drugs, contributing to the solution of various diseases.
In the field of materials science, 2 - (4 - methylphenyl) pyridine also shows unique value. In the preparation of organic optoelectronic materials, its rational introduction into the material structure can effectively regulate the photoelectric properties of the material. For example, in the development of organic Light Emitting Diode (OLED) materials, it can optimize the luminous efficiency and stability of the material, promote the display device to show more vivid and realistic colors, and contribute to the improvement of display technology.
In addition, in the field of catalysis, 2 - (4-methylphenyl) pyridine can be combined with metal ions as a ligand to form a metal complex catalyst with excellent performance due to its special structure and electronic properties. Such catalysts exhibit high catalytic activity and selectivity in many chemical reactions, significantly improving reaction efficiency, reducing reaction costs, and promoting the development of chemical production and other industries in a more efficient and greener direction. In short, 2- (4-methylphenyl) pyridine plays an indispensable role in many important fields and has a profound impact on scientific and technological progress and industrial development.

2-%284-Methylphenyl%29pyridine is 2- (4-methylphenyl) pyridine, which is an organic compound. Its physical properties are as follows:
Viewed at room temperature, it is a colorless to pale yellow liquid or a crystalline solid. Due to the difference in the orderly arrangement of molecular structures, it presents different aggregates.
Smell, has a special odor, which is a common characteristic of organic compounds. Its odor originates from a specific molecular structure and functional group, which stimulates olfactory receptors.
Its melting point and boiling point are related to the intermolecular force. The melting point is about [specific value]. At this time, the molecule overcomes the lattice energy and changes from a solid state to a liquid state. The boiling point is about [specific value]. At this temperature, the molecule obtains enough energy to overcome the intermolecular force and change from a liquid state to a gaseous state. This is because the molecule contains a pyridine ring and a methyl phenyl group, which interact with each other, and the melting boiling point is in a specific range.
When it comes to solubility, it is slightly soluble in water, but easily soluble in organic solvents, such as ethanol, ether, chloroform, etc. Water is a polar solvent. Although the compound has a polar pyridine ring, the methyl phenyl group is a non-polar part, and the overall polarity is limited. According to the principle of "similar miscibility", it is more compatible with organic solvents.
Its density is also an important physical property, about [specific value] g/³ cm. The density is affected by the molecular mass and the close arrangement between molecules. The specific structure of this compound determines its density value.
The above physical properties are of great significance in the fields of organic synthesis and materials science. In the synthesis, the separation and purification method is selected according to its melting and boiling point; in the preparation of materials, the appropriate solvent is selected according to its solubility. Only by understanding its physical properties can it be used well and play a greater role in related fields.

2 -% 284 - Methylphenyl%29pyridine is 2 - (4 - methylphenyl) pyridine. The chemical properties of this compound are quite critical and have their uses in many chemical fields.
It is basic, and the nitrogen atom of the Geyne pyridine ring has lone pairs of electrons, which can accept protons and can form salts in acidic media. This alkalinity makes it possible to react with acid substances to form corresponding salt compounds.
Furthermore, the compound is aromatic. Both the pyridine ring and the benzene ring have conjugated systems and have high stability. Aroma gives it a special electron cloud distribution, which affects its reactivity and selectivity. The substitution reaction of 2 - (4 -methylphenyl) pyridine is also worthy of attention. Due to the difference in electron cloud density between the pyridine ring and the benzene ring, the substitution reaction check point is different. On the benzene ring, the methyl group is the donator group, which increases the electron cloud density of the ortho-and para-position of the benzene ring, and the electrophilic substitution reaction easily occurs in the ortho-and para-position; the nitrogen atom of the pyridine ring absorbs electrons, which reduces the electron cloud density of the pyridine ring. The electrophilic substitution reaction is more difficult than that of the benzene ring, and mainly occurs at the β position.
In addition, it may also participate in the coupling reaction. Under appropriate catalyst and reaction conditions, it can be coupled with halogenated hydrocarbons and other compounds to form more complex organic molecular structures, which is an important reaction path in organic synthesis chemistry.
2- (4-methylphenyl) pyridine has unique chemical structure, basic, aromatic and other chemical properties, and shows special reactivity and selectivity in substitution reactions, coupling reactions, etc., and has potential application value in many fields such as organic synthesis and pharmaceutical chemistry.

2-% (4-methylphenyl) pyridine is also an organic compound. Its synthesis method has been explored by many scholars in the past, and the current Chen number method is as follows.
First, using 4-methylphenylboronic acid and 2-halogenated pyridine as raw materials, it was prepared by the Suzuki-Miyapu coupling reaction catalyzed by palladium. This reaction condition is mild and good selectivity, and it is a commonly used method for synthesizing such compounds. During the reaction, 4-methylphenylboronic acid, 2-halogenated pyridine, palladium catalyst, base and solvent are mixed in a certain proportion, and the reaction is stirred at an appropriate temperature. The palladium catalysts used, such as tetrakis (triphenylphosphine) palladium, can effectively promote the reaction; potassium carbonate, sodium carbonate, etc. are commonly used in alkalis; dioxane, toluene, etc. are selected as solvents. After this reaction, the halogen atom is coupled with the borate group to obtain the target product 2 - (4 - methylphenyl) pyridine.
Second, the Grignard reagent method can be used. First prepare 4-methylphenyl magnesium halide, that is, 4-methylhalobenzene reacts with magnesium chips in anhydrous ether or tetrahydrofuran to obtain Grignard reagents. Then it is reacted with 2-pyridinone, and the reaction is completed. After acidification, the hydroxyl group is replaced by a halogen atom, and then reduced to obtain 2- (4-methylphenyl) pyridine. In this process, the anhydrous and anaerobic conditions are quite critical to prevent the failure of Grignard's reagent.
Third, 2-methylpyridine and 4-methylbenzaldehyde are used as starting materials, and are synthesized through a series of reactions such as condensation and reduction. The two are condensed under basic conditions to form enamines intermediates, and then reduced by suitable reducing agents such as sodium borohydride to obtain the target product. This approach is slightly complicated, but the raw materials are relatively easy to obtain, which is also a feasible method.
All these methods have advantages and disadvantages. Chemists can choose according to factors such as the availability of raw materials, the difficulty of reaction conditions, and the requirements of product purity, so as to achieve the purpose of synthesizing 2- (4-methylphenyl) pyridine.

In today's world, business conditions are ever-changing, and it is not easy to determine the price range of 2 - (4 - methylphenyl) pyridine in the market. This compound is widely used and has its uses in medicine and materials, and its price is also affected by many factors.
First, the quality is related to the price. If the quality is excellent, impurities are rare, and it meets the requirements of high standards of purity, the price will be high; on the contrary, if the quality is slightly inferior and contains some impurities, the price may be slightly lower.
Second, the amount of output is also the key. If the market is abundant and the production scale is large, according to the reason of supply and demand, the price may stabilize and drop slightly; if the output is scarce and the supply is in short supply, the price will rise.
Third, the preparation process is difficult and easy to distinguish. If the process is complicated, rare raw materials are required, and after multiple cumbersome processes, the cost will be high, and the price will also rise; if the process is relatively simple, the cost is controllable, and the price may be relatively close to the people.
Looking at past transactions, the price of this compound fluctuates significantly. At some times, due to the shortage of raw materials and the lack of process improvement, the price can reach tens of gold per gram; at other times, due to production expansion and increased competition, the price may drop to several gold per gram.
However, to obtain an accurate price range, it is necessary to consult chemical raw material suppliers, trading platforms, or study the latest market survey reports in real time to gain insight into the current price and provide an exact basis for business and R & D.