2-(4-fluorophenyl)pyridine

2-%284-fluorophenyl%29pyridine is 2- (4-fluorophenyl) pyridine, which has a wide range of uses. In the field of medicinal chemistry, it is often a key raw material for the creation of new drugs. Because of its specific chemical structure, it can interact with specific targets in organisms, helping to develop new drugs with high efficiency and low toxicity.
In the field of materials science, 2- (4-fluorophenyl) pyridine plays an important role. In the synthesis of organic Light Emitting Diode (OLED) materials, its introduction into the molecular structure can effectively improve the luminous properties of materials, such as improving luminous efficiency and prolonging service life, which in turn promotes the wide application of OLED technology in display fields, such as high-end mobile phones, TV displays, etc.
In the field of catalytic chemistry, 2- (4-fluorophenyl) pyridine can act as a ligand to complex with metal ions to form a catalyst with unique properties. Such catalysts exhibit excellent catalytic activity and selectivity in many organic synthesis reactions, promoting the development of organic synthesis chemistry and providing an effective way for the preparation of various fine chemicals and functional materials.
In terms of scientific research and exploration, as an intermediate in organic synthesis, 2- (4-fluorophenyl) pyridine can be derived from a wide range of compounds with different structures for researchers to further explore their physical, chemical and biological properties, laying the foundation for the creation and performance optimization of new substances. It is of great significance for both basic and applied research in chemistry.

To prepare 2 - (4 - fluorophenyl) pyridine, the number method is often followed. First, 4 - fluorophenylboronic acid and 2 - halogenated pyridine are used as raw materials and obtained by Suzuki coupling reaction. This reaction requires palladium catalysts such as tetra (triphenylphosphine) palladium and alkalis such as potassium carbonate. In an organic solvent such as toluene, dioxane and water mixed system, heating and stirring, the halogen atom of halogenated pyridine is cross-coupled with the borate group to form the target product. Its advantages are that the reaction conditions are milder, the yield is acceptable, and the substrate is easy to find.
Second, it can be prepared by the condensation reaction of 4 - fluorophenylacetone and pyridine. Using a strong base such as sodium amide as the condensation agent, in an appropriate solvent such as liquid ammonia, the carbonyl α-hydrogen of 4-fluoroacetophenone is captured by the base to form a carbon negative ion, which attacks the α-position of pyridine, and obtains 2- (4-fluorophenyl) pyridine through dehydration and other steps. The raw material of this route is simple, but the use of strong bases needs to be cautious and the operation requirements are high.
Third, using 2-methylpyridine and 4-fluorobromobenzene as the starting materials, it is synthesized through a metal-catalyzed C-H activation reaction. Using transition metals such as rhodium and palladium complexes as catalysts and adding guide groups to assist, the aromatic group of 4-fluorobromobenzene is directly coupled to the α-position carbon-hydrogen bond of 2-methylpyridine. The method has good atomic economy and simple steps, but the catalyst is more expensive and the reaction conditions need to be fine-tuned.
All synthesis methods have advantages and disadvantages, and the practical application depends on factors such as raw material availability, cost, yield and purity requirements.

2-%284-fluorophenyl%29pyridine, or 2- (4-fluorophenyl) pyridine, is an important compound in organic chemistry. Its physical properties are of great interest and are of great significance for its application in various chemical processes and material construction.
In terms of appearance, 2- (4-fluorophenyl) pyridine is often in the state of white to pale yellow crystalline powder. This form is easy to store and handle, and is easy to measure and use in many chemical reactions, which facilitates the precise control of the synthesis process.
Its melting point is between 63 and 67 ° C. This property of melting point plays a significant role in the purification and identification of compounds. By means of melting point determination, the purity of the compound can be determined. If the melting point of the sample is consistent with the literature and the melting range is narrow, it implies that its purity is quite high; conversely, if the melting point deviation is large or the melting range is wide, it indicates that the sample may contain impurities.
In terms of boiling point, 2- (4-fluorophenyl) pyridine is about 284 ° C. The boiling point is related to the temperature node at which the compound changes from liquid to gaseous state when heated, and is of great significance in separation and purification operations such as distillation. With this property, it can be effectively separated from other substances with different boiling points.
Solubility is also one of the key properties. 2 - (4 - fluorophenyl) pyridine is soluble in common organic solvents such as dichloromethane, chloroform, tetrahydrofuran, etc. This solubility property makes it easy to dissolve and disperse in organic synthesis reactions, creating favorable conditions for the development of various chemical reactions, enabling full contact between reactants and speeding up the reaction process. However, its solubility in water is very small, which is related to the large proportion of hydrophobic groups in its molecular structure, which also affects its application in different media.
The density of 2 - (4 - fluorophenyl) pyridine is about 1.21 g/cm ³. Density, as an inherent property of a substance, is indispensable when it comes to solution preparation, volume and mass conversion of reactive materials, etc., providing a guarantee for the accuracy of experimental operations.
In addition, 2 - (4 - fluorophenyl) pyridine has a certain degree of volatility, and it will evaporate slowly at room temperature and pressure. Although the volatility is not strong, it is still necessary to pay attention during storage and use. It should be operated in a well-ventilated place to avoid its accumulation in the air.
The physical properties of 2 - (4 - fluorophenyl) pyridine mentioned above, such as appearance, melting point, boiling point, solubility, density and volatility, are interrelated and affect its application in the chemical field. In many fields such as organic synthesis and materials science, in-depth understanding of these properties is necessary to make rational use of the compound and achieve the desired experimental and production goals.

2-%284-fluorophenyl%29pyridine is 2- (4 -fluorophenyl) pyridine, and its chemical properties are unique.
It is basic, and the nitrogen atom of the pyridine ring is rich in lone pairs of electrons, which can accept protons, and can form pyridine salts in acidic media. This basic property makes it play a key role in many organic reactions, such as participating in acid-base catalysis.
Furthermore, the compound is aromatic. Both the pyridine ring and the benzene ring have conjugated systems, resulting in enhanced stability and exhibiting typical reaction characteristics of aromatic compounds, such as electrophilic substitution reactions. Due to the existence of fluorine atoms and pyridine rings, the electron cloud distribution is different, and the electrophilic substitution reaction check point is also affected. Usually, the electron cloud density on the pyridine ring is relatively low, and the electrophilic substitution reaction is more difficult than the benzene ring. Under specific conditions, it can also occur, and the substitution position is mostly affected by the electronic effect of the fluorine atom and the pyridine ring.
In terms of solubility, 2- (4-fluorophenyl) pyridine is an organic compound. It has certain solubility in common organic solvents such as ethanol, ethyl ether, dichloromethane, etc., but it has poor solubility in water. Due to the limited polarity of the molecule, the force between the molecule and the water molecule is weak.
From the chemical stability point of view, under normal conditions, the compound is relatively stable, but when exposed to extreme conditions such as strong oxidants, strong acids, strong bases or high temperatures, the structure may change, triggering reactions such as oxidation and hydrolysis.
In addition, the fluorine atom of 2- (4-fluorophenyl) pyridine has a unique electronic effect and strong electron absorption ability, which can affect the distribution of molecular electron clouds and reactivity, and then have a profound effect on its chemical properties and reaction pathways.

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