2,4-Dichloro-5-carbethoxypyridine

2% 2C4-difluoro-5-ethoxy pyridone, which has a wide range of uses. In the field of medicine, it is often used as a key intermediate for the synthesis of many drugs. The structure of Geinpyridone has unique chemical activity and can interact with a variety of targets in organisms. By introducing specific substituents, such as 2% 2C4-difluoro and 5-ethoxy, the activity, selectivity and pharmacokinetic properties of drug molecules can be precisely adjusted. For example, in the development of antibacterial drugs, it can be used to construct new compounds with high antibacterial activity and low toxic and side effects.
In the field of pesticides, 2% 2C4-difluoro-5-ethoxypyridone also plays an important role. It can be used as an important raw material for the synthesis of pesticides and fungicides. With its special structure, it can interfere with the normal physiological metabolism of pests or pathogens, and achieve the purpose of preventing and controlling pests and diseases. And because of its novel structure, compared with traditional pesticides, it may have higher activity and environmental friendliness, which can ensure agricultural production while reducing the negative impact on the ecological environment.
In the field of materials science, this compound also has potential applications. Its structural properties may give it unique advantages in the synthesis of functional materials, such as for the preparation of organic materials with specific optical and electrical properties, injecting new vitality into the development of materials science.

There are many synthesis methods of 2% 2C4-dihydro-5-ethoxycarbonyl pyridine, which are listed in detail below:
###1. Pyridine derivatives are used as starting materials
1. ** Reduction and substitution method **: If the starting material is a suitable pyridine derivative, the pyridine ring can be reduced with a suitable reducing agent, such as sodium borohydride ($NaBH_4 $) or lithium aluminum hydride ($LiAlH_4 $), so that the double bond on the pyridine ring is partially hydrogenated to generate 2,4-dihydropyridine derivatives. Subsequently, ethoxy anions are prepared by the reaction of halogenated alkanes (such as bromoethane) with sodium alcohols (such as sodium ethanol), and then nucleophilic substitution occurs with the appropriate substitution check point on 2,4-dihydropyridine derivatives, and ethoxy carbonyl is introduced at 5 positions to obtain the target product. This process requires attention to the control of reaction conditions. The amount of reducing agent, reaction temperature and time will all affect the reaction process and product purity.
2. ** Metal catalytic coupling method **: Using 5-halo-2,4-dihydropyridine as raw material, under the action of transition metal catalysts such as palladium ($Pd $), the coupling reaction is carried out with ethoxy carbonylation reagents, such as vinyl ethyl carbonate. The choice of metal catalyst and ligand is crucial, which will significantly affect the reactivity and selectivity. The reaction system also needs to add bases, such as potassium carbonate ($K_2CO_3 $), to promote the reaction.
###Second, the method of constructing pyridine rings
1. ** Hantzsch synthesis method **: Using ethyl acetoacetate, formaldehyde and ammonia (or ammonium salt) as raw materials, under acid catalysis, a pyridine ring is constructed through multi-step reaction. At the beginning of the reaction, ethyl acetoacetate and formaldehyde undergo hydroxyaldehyde condensation reaction to form an unsaturated carbonyl compound. Subsequently, this compound reacts with ammonia to form imine, which then undergoes Michael addition reaction with another molecule of ethyl acetoacetate, and finally cyclizes and dehydrates to form 2,4-dihydropyridine derivatives. Through a subsequent appropriate esterification reaction, ethoxycarbonyl is introduced at position 5. The raw materials of this method are easy to obtain, the reaction conditions are relatively mild, but there are many steps, and each step needs to be carefully controlled to improve the yield and purity.
2. Microwave-assisted synthesis method: In the process of constructing pyridine rings, the use of microwave radiation technology can accelerate the reaction process. With raw materials similar to Hantzsch synthesis method, under microwave radiation, the reaction rate is greatly increased and the reaction time is significantly shortened. The rapid heating characteristics of microwave make the reaction system heated uniformly, which is conducive to improving the selectivity of the reaction and the purity of the product. However, this method requires specialized microwave equipment, which requires more accurate control of the reaction conditions.

I don't know the market price of 2,4-difluoro-5-ethoxypyridine. However, if you want to know its price, you can follow various ways.
First, the market seeks it. In the place of chemical trade, find a merchant dealing in this chemical and inquire about its price. However, this journey may require going to the market in person, which is quite laborious, and the pricing of different merchants may vary.
Second, visit it online. In today's world, the Internet is developed, and you can type "2,4-difluoro-5-ethoxypyridine price" words on chemical product trading platforms, search engines, etc., to search for relevant information. On the platform, many merchants list products and prices, but their prices also change with market supply and demand and quality.
Third, ask the manufacturer. If you get the contact information of the manufacturer of this product and ask directly, you can get a more accurate price. And communicate with the manufacturer, or be able to know the discount for bulk purchase.
The market price often fluctuates due to many factors such as raw material costs, production processes, market supply and demand. Raw material prices rise, production costs increase, and their prices may rise; market demand is strong, but supply is small, prices will also rise; if new production processes come out, costs will drop, and prices may fall. Therefore, in order to know the real-time and accurate market price, it is advisable to explore multiple channels and compare comprehensively.

The physical and chemical properties of 2% 2C4-difluoro-5-ethoxy pyridine are as follows:
This substance is usually in a liquid or solid state, depending on the specific conditions. In terms of appearance, it may be a colorless to pale yellow transparent liquid when pure, and may appear as a crystalline solid if it is solid.
From the perspective of melting and boiling points, its melting and boiling points are determined by intermolecular forces and structural characteristics. The fluorine atom and ethoxy group in the molecule will have a significant impact on the melting and boiling point. The electronegativity of fluorine atoms is large, which can enhance the interaction between molecules. The presence of ethoxy groups increases the relative mass and steric resistance of molecules. In general, its boiling point will be in a certain range due to the presence of these groups, relatively high, and the specific value needs to be accurately determined by experiments.
In terms of solubility, due to the simultaneous existence of polar fluorine atoms and relatively non-polar ethoxy groups in the molecule, it has certain characteristics in solubility. In polar organic solvents, such as ethanol, acetone, etc., the interaction between fluorine atoms and solvent molecules has good solubility; in non-polar solvents such as n-hexane, the ethoxy part may have a certain affinity with the solvent, but the overall solubility may not be as good as in polar solvents.
Chemically, the pyridine ring imparts a certain alkalinity to the substance, and the nitrogen atom can accept protons. At the same time, due to its strong electronegativity, fluorine atoms reduce the electron cloud density of carbon atoms connected to them. Under certain conditions, nucleophilic substitution reactions can occur, such as being attacked and replaced by other nucleophilic reagents. Oxygen atoms in ethoxy groups have lone pairs of electrons and can also participate in some chemical reactions, such as reacting with electrophilic reagents. In addition, this substance may also participate in common organic reactions such as oxidation and reduction. The specific reactivity is closely related to the reaction conditions, such as reaction temperature, reactant concentration, and the presence or absence of catalysts.

When storing and transporting 2% 2C4-dihydro-5-ethoxycarbonyl pyridine, the following matters should be paid attention to:
First, the storage place must be cool and dry. This is because the substance is quite sensitive to humidity and temperature. High temperature or humid environment can easily cause chemical reactions and damage the quality. If placed in a humid place, water vapor may interact with the substance to initiate reactions such as hydrolysis; under high temperature, or accelerate its decomposition process. Therefore, it is advisable to choose a well-ventilated warehouse with a constant temperature of 15-25 ° C and a relative humidity of 40% -60%.
Second, keep away from fire sources and oxidants. 2% 2C4-dihydro-5-ethoxycarbonyl pyridine is flammable to a certain extent. It is easy to burn and even explode when exposed to open flames and hot topics. The oxidant will react violently with it, increasing the risk of fire and explosion. In the storage area, fireworks are strictly prohibited, and they should be stored separately from the oxidant, with a spacing of more than 3 meters.
Third, when transporting, ensure that the packaging is intact. If the packaging of this substance is damaged, it is easy to leak, which is not only wasted, pollutes the environment, but also may endanger the safety of transporters. Before loading, the packaging must be carefully inspected. If there is any damage or deformation, replace it in time. During transportation, anti-collision, turbulence, and damage to the packaging.
Fourth, follow relevant regulations and standards. Whether it is storage or transportation, it must strictly comply with national and industry regulations and standards. From the setting of storage conditions to the preparation of transportation documents, all must act in accordance with regulations. When transporting, prepare chemical safety technical instructions and chemical labels for emergency and identification use.