2-(4-Aminophenyl)pyridine

The main uses of 2- (4-hydroxybenzyl) pyridine are in the fields of medicine, chemical industry, etc.
In the field of medicine, it is often an important pharmaceutical intermediate. The synthesis of many drugs depends on it as a starting material or a key structural unit. For example, several compounds with specific biological activities can be chemically modified and reacted on the basis of 2- (4-hydroxybenzyl) pyridine to have the effect of treating specific diseases. For example, in the development of some anti-tumor drugs, this compound may play an important role in the construction of drug active structures, and can participate in the construction of key fragments of drug molecules, affecting the ability of drugs to bind to targets, and then affecting the efficacy and specificity of drugs. < Br >
In the chemical industry, it is also quite useful. It can be used to synthesize polymer materials with special properties. By polymerizing with other monomers, its unique structure can be introduced into the polymer chain, giving the material special physical and chemical properties. For example, it has better solubility, thermal stability or optical properties. Furthermore, in the synthesis of dyes, 2- (4-hydroxybenzyl) pyridine can be used as raw materials to synthesize dyes with specific colors and dyeing properties to meet different industrial and life needs. Due to the presence of hydroxyl groups and pyridine rings in its structure, it can participate in various chemical reactions, providing the possibility for the synthesis of dyes with various functions. Therefore, 2 - (4 -hydroxybenzyl) pyridine has important uses in the pharmaceutical and chemical industries, and is an indispensable key compound for the development and production of many products.

2 - (4 -Aminophenyl) pyridine is an organic compound with unique physical and chemical properties. Its shape may be a crystalline solid, and it is stable at room temperature and pressure.
On the melting point, the specific value can be obtained through experimental determination or literature review. This is an important index for determining the purity and characteristics of the substance. The boiling point is also critical, reflecting its temperature from liquid to gaseous state under a specific pressure, related to its volatility and stability under different conditions.
In terms of solubility, 2- (4-aminophenyl) pyridine may exhibit some solubility in organic solvents, such as common ethanol, dichloromethane, N, N-dimethylformamide, etc., but its solubility in water may be poor. This property is related to the hydrophobic aromatic ring and relatively weak polar groups contained in the molecular structure.
The density of 2- (4-aminophenyl) pyridine is also one of its physical properties. Although there is no exact data, it can be inferred based on compounds with similar structures. Density is related to the degree of close arrangement between molecules of a substance, which affects its behavior and application in a specific system.
In chemical properties, the amino group in the molecule has a certain alkalinity and can react with acids to form corresponding salts. The pyridine ring makes the compound aromatic and can participate in a variety of electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. The o and para electron cloud density of amino groups is high, and electrophilic reagents are easy to attack these positions. In addition, the compound may also participate in the coupling reaction catalyzed by transition metals, providing the possibility for the construction of more complex organic structures.

2 - (4 -Aminophenyl) pyridine, its chemical properties are as follows:
This compound contains amino and pyridine structures, so it has a unique chemical activity. The amino group is the donator group, which increases the density of the electron cloud of the benzene ring, making it more susceptible to electrophilic substitution. In the aromatic electrophilic substitution reaction, the amino group makes the ortho and para-sites of the benzene ring more active. For example, when halogenated, the halogen atom is easily attached to the amino ortho and para-sites.
The pyridine ring is basic, and the nitrogen atom has lone pair electrons, which can form salts with acids. Like reacting with hydrochloric acid, the nitrogen atom of the pyridine accepts protons and produces pyridine hydrochloride. Because the pyridine ring is aromatic and relatively stable, it can also participate in reactions such as nucleophilic substitution, but the conditions are harsh.
This compound also has a conjugated system. Because the benzene ring is conjugated with the pyridine ring, it has special optical and electrical properties. The conjugated structure causes it to absorb in the ultraviolet-visible region and can be used for spectral analysis. Some compounds containing the conjugated system also have fluorescent properties, or can be used in fluorescent materials.
Because of the amino group and the pyridine ring, 2- (4-aminophenyl) pyridine can be used as an intermediate in organic synthesis. It can be chemically reacted to connect different functional groups or structural fragments to produce organic compounds with various structures and functions. It is widely used in medicine, materials and other fields. For example, in pharmaceutical research and development, its structural modification and optimization can be used to obtain lead compounds with specific biological activities.

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First, halogenated aromatics and amines are used as raw materials, and prepared by Buchwald-Hartwig amination reaction under the action of palladium catalyst, ligand and base. The reaction conditions are mild, the compatibility of various substituents is good, and the carbon-nitrogen bond can be efficiently constructed. In the process, the palladium catalyst is first complexed with the ligand to enhance its catalytic activity, then oxidized with halogenated aromatics, and then nucleophilic substitution with amines, and finally the target product is eliminated by reduction.
Second, with the help of Ullmann reaction, copper salts are used as catalysts to directly react halogenated aromatics with amines to form 2- (4-aminophenyl) under high temperature and alkaline conditions. This method has a long history, but the reaction conditions are relatively harsh, requiring high temperatures and special requirements for substrates, but it has unique advantages in the synthesis of some specific structural products. Copper catalysts undergo complex redox cycles in the reaction to achieve the formation of carbon-nitrogen bonds.
Third, cross-coupling reactions catalyzed by transition metals, such as the Negishi reaction, Suzuki reaction, etc. Derivatization methods. First, suitable organometallic reagents are coupled with halogenated aromatics under transition metal catalysis, and then amino groups are introduced through subsequent conversion to obtain the target product. This method is highly flexible and can achieve diverse structural modifications by selecting different organometallic reagents and halogenated aromatics. Taking the Negishi reaction as an example, organozinc reagents and halogenated aromatics are coupled under nickel or palladium catalysis through conversion metallization, oxidative addition and reduction elimination steps.

There are now di- (tetra- aminopyridine), and I would like to know its price range in the market. Looking at the method of "Tiangong Kaiwu", although it does not specify the price of this product in detail, the common sense of pricing can be deduced to answer it.
The price of the husband's product often depends on supply and demand, the difficulty of preparation, and the quality. If di- (tetra- aminopyridine) is widely needed, and there are few supplies, the price will be high; if it is easy to prepare and the output is abundant, the price will be low. < Br >
Preparation of di- (tetra- aminopyridine), if the method is difficult, requires concentrate and good utensils, and takes a long time and requires a lot of labor, the cost will be high, and the price will also be high. On the contrary, if the preparation is simple, the materials used are frequent, the cost will decrease, and the price will also decrease.
In addition, its quality is also related to the price. If the quality is pure, flawless, and meets the standards of various uses, the price will be considerable; if the quality is miscellaneous, defective, and not as desired, the price will be low.
In today's market, the price of di- (tetra- aminopyridine) varies due to the above factors. Roughly speaking, the price may be between a few yuan per gram and a few dozen yuan. However, this is only an approximate number. The actual price can fluctuate depending on the specific circumstances of the time and market, such as the distance of the place of origin, the cost of logistics, and the increase or decrease of taxes. Therefore, in order to know the exact price, it is necessary to carefully check the local market conditions at that time and consult the industry before you can get it.