2 4 6 Trimethylpyridine
pyridine pyrrole pyrazine piperidine piperazine

2,4,6-Trimethylpyridine

    Specifications

    HS Code

    646188

    Chemical Formula C8H11N
    Molar Mass 121.18 g/mol
    Appearance Colorless to yellowish liquid
    Odor Pungent, pyridine - like odor
    Density 0.945 g/cm³ at 20 °C
    Boiling Point 171 - 172 °C
    Melting Point -45 °C
    Solubility In Water Slightly soluble
    Solubility In Organic Solvents Soluble in ethanol, ether, etc.
    Flash Point 57 °C
    Vapor Pressure 1.33 kPa at 48.8 °C

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    General Information
    Where to Buy 2,4,6-Trimethylpyridine in China?
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    Frequently Asked Questions

    As a leading 2,4,6-Trimethylpyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 2,4,6-trimethylpyridine?
    2%2C4%2C6-%E4%B8%89%E7%94%B2%E5%9F%BA%E5%90%A1%E5%95%B6%E7%9A%84%E7%89%A9%E7%90%86%E6%80%A7%E8%B4%A8%E4%B8%8B%E6%96%B9%E5%B0%86%E4%B8%BA%E5%88%99%E5%8D%B3%E8%AF%B4%E3%80%82
    This substance is called 2,4,6-trimethylpyridine. It is like water. It is a colorless to light yellow transparent liquid at room temperature and has a special odor. Its boiling point is quite high, about 171 ° C, and its melting point is low, nearly -45 ° C. The density is slightly higher than that of water, about 0.926g/cm ³.
    2,4,6-trimethylpyridine is slightly soluble in water, but easily soluble in organic solvents such as ethanol and ether. Due to its molecular structure, the nitrogen atom of the pyridine ring has lone pairs of electrons, which can interact with organic solvent molecules, so it has good solubility.
    In terms of chemical properties, 2,4,6-trimethylpyridine is a weakly basic substance. The nitrogen atom of the pyridine ring can accept protons and react with acids to form salts. Its alkalinity is weaker than that of aliphatic amines, but stronger than that of anilines. Due to the conjugation effect of the pyridine ring, the electron cloud density on the nitrogen atom decreases, and the attraction to protons weakens.
    2,4,6-trimethylpyridine can also participate in electrophilic substitution reactions. The electron cloud density on the pyridine ring is uneven, and the electron cloud density at the α and γ positions is lower than that at the β position, so the electrophilic substitution reaction mostly occurs at the β position. In addition, its methyl group is affected by the pyridine ring and has certain reactivity, which can occur reactions such as oxidation.
    In the field of industry and scientific research, 2,4,6-trimethylpyridine is widely used. It can be used as a solvent and catalyst, and is also used in organic synthesis such as drugs and dyes.
    What are the chemical properties of 2,4,6-trimethylpyridine?
    2% 2C4% 2C6-trimethylpyridine is an organic compound. It has many chemical properties, which are described as follows:
    First, the alkalinity is significant. The nitrogen atom of 2,4,6-trimethylpyridine contains lone pairs of electrons, which can accept protons and is alkaline. In aqueous solution, it can react with acids to form corresponding salts. For example, when interacting with hydrochloric acid, 2,4,6-trimethylpyridine hydrochloride is formed. This property makes it widely used in the absorption, separation and catalytic reaction of acidic substances.
    Second, the activity of nucleophilic substitution is high. The carbon atom on the pyridine ring is in an electron-deficient state due to the electronegativity of the nitrogen atom. When encountering nucleophiles, leaving groups such as halogen atoms on the pyridine ring are easily replaced by nucleophiles. For example, when co-heating with sodium hydroxide solution, if there are suitable halogen atoms attached to the pyridine ring, the halogen atoms can be replaced by hydroxyl groups.
    Third, oxidation reactions are diverse. 2,4,6-trimethylpyridine can be oxidized by specific oxidants. Treated with strong oxidants such as potassium permanganate, the pyridine ring may be oxidized and destroyed to form oxidation products such as carboxylic acids; while with mild oxidant action, or selective oxidation of side chain methyl groups, oxygen-containing functional groups such as aldehyde or carboxyl groups are formed.
    Fourth, alkylation and acylation reactions are prone to occur. In the presence of an appropriate catalyst, the nitrogen atom of 2,4,6-trimethylpyridine can be alkylated with halogenated hydrocarbons to form quaternary ammonium salts; it can also be acylated with acyl halide or acid anhydride to introduce acyl groups on nitrogen atoms. These reaction products are of great significance in the fields of organic synthesis and medicinal chemistry.
    Fifth, good coordination ability. The nitrogen atom of 2,4,6-trimethylpyridine can be used as a ligand to form a coordination compound with metal ions. With this coordination effect, it can be used for the separation and purification of metal ions, and can also participate in metal catalytic reactions as a ligand to improve catalyst activity and selectivity.
    In which fields is 2,4,6-trimethylpyridine used?
    2%2C4%2C6-%E4%B8%89%E7%94%B2%E5%9F%BA%E5%90%A1%E8%80%85 is an important compound in organic chemistry. It is widely used and plays a key role in many fields.
    In the field of medicine, 2%2C4%2C6-%E4%B8%89%E7%94%B2%E5%9F%BA%E5%90%A1%E5%8F%AF as an intermediate for drug synthesis. Through specific chemical reactions, it can be converted into compounds with specific pharmacological activities, such as antibacterial, anti-inflammatory, anti-tumor and other drugs. These drugs are of great significance to human health and can effectively treat a variety of diseases and relieve the pain of patients.
    In the field of materials science, it also has significant contributions. It can be used as a monomer for synthesizing polymer materials and polymerized to form polymers with special properties. These polymers may have excellent heat resistance, corrosion resistance and mechanical properties, and are widely used in aerospace, automobile manufacturing, electronics and other industries. For example, high-performance composites used in the aerospace field, some of them need to be synthesized with the help of 2%2C4%2C6-%E4%B8%89%E7%94%B2%E5%9F%BA%E5%90%A1 to meet the strict requirements of high-performance materials for aircraft.
    Furthermore, in the agricultural field, 2%2C4%2C6-%E4%B8%89%E7%94%B2%E5%9F%BA%E5%90%A1 can be used to synthesize pesticides. Through rational design and synthesis, pesticide products with high-efficiency killing effect on pests and environmental friendliness can be prepared, which can help improve crop yield and quality and ensure food security.
    In addition, in the coating industry, it can be used as one of the coating ingredients. Adding this substance can improve the performance of the coating, such as improving the adhesion, wear resistance and weather resistance of the coating, so that the coating can better protect the surface of the coated object and prolong the service life of the object.
    In short, 2%2C4%2C6-%E4%B8%89%E7%94%B2%E5%9F%BA%E5%90%A1 is indispensable in many fields such as medicine, materials, agriculture, coatings, etc., and plays an important role in promoting the development of various industries.
    What is the preparation method of 2,4,6-trimethylpyridine?
    2%2C4%2C6-%E4%B8%89%E7%94%B2%E5%9F%BA%E5%90%A1%E5%95%B6%E7%9A%84%E5%88%B6%E5%A4%87%E6%96%B9%E6%B3%95%E4%B8%8E%E5%8E%9F%E7%90%86%EF%BC%9A
    To make 2%2C4%2C6-%E4%B8%89%E7%94%B2%E5%9F%BA%E5%90%A1%E5%95%B6%2C is often done by chemical methods. The method is as follows:
    First take the amount of raw material, often with a compound group. For example, with a specific compound starting material, the compound needs to have a functional group that can be reversed, in order to facilitate the introduction of trimethylphenyl.
    Replace the reactive element with the reactive element and the reactive element. Such as the use of reactive trimethylbenzene, such as Grignard (RMgX, R-group, X-element), in a suitable solution, at a certain degree and reaction, the atom of the reactive trimethylbenzene is replaced by a reactive group, and the trimethylphenyl group is introduced into the target molecule.
    Or use a Friedel-Crafts alkylation reaction. With an aromatic substrate, in the presence of Lewis acid catalysis (such as AlCl, etc.), the trimethylphenyl is substituted with trimethylbenzene or allyltrimethylbenzene to form a 2%2C4%2C6-%E4%B8%89%E7%94%B2%E5%9F%BA%E5%90%A1%E5%95%B6 molecule.
    After the reaction, because the reaction system often contains raw materials, by-products, etc., it is necessary to take steps to improve the reaction. You can use the method of steaming, according to the difference between the boiling of each object, to distinguish the object from the eye; or use the method of column precipitation, according to the difference in the distribution of the substance in the stationary phase of the flow phase, until the purpose of the separation, in order to obtain a high degree of 2%2C4%2C6-%E4%B8%89%E7%94%B2%E5%9F%BA%E5%90%A1%E5%95%B6.
    Of course, the 2%2C4%2C6-%E4%B8%89%E7%94%B2%E5%9F%BA%E5%90%A1%E5%95%B6 requires fine raw materials, making good use of the reaction, and paying attention to the technology of separation and extraction.
    What is the market outlook for 2,4,6-trimethylpyridine?
    The market prospect of 2,4,6-trimethylpyridine is actually intertwined by many factors.
    From the demand side, this compound has a wide range of uses in the field of pharmaceutical synthesis. The preparation of many drugs depends on it as a key intermediate. With the booming state of the pharmaceutical industry, the pursuit of various specific drugs has not yet been pursued, which creates a broad demand space for 2,4,6-trimethylpyridine. For example, in the process of anti-cancer drug research and development, precise organic synthesis is often required, and 2,4,6-trimethylpyridine may play an important role in promoting the birth of new drugs, so the demand in the pharmaceutical field may be steadily rising.
    In the field of materials science, it has also emerged. With the advancement of high-tech materials, such as polymer materials with special functions, 2,4,6-trimethylpyridine can introduce a unique chemical structure through specific reactions, giving the material novel properties, such as better stability or special optical properties. The emerging material industry is in the ascendant, and the demand for it is expected to grow gradually.
    However, there are also challenges. First, the production process. The process of preparing 2,4,6-trimethylpyridine may be difficult due to high complexity and high cost. If the production enterprise fails to effectively optimize the process, reduce costs and increase efficiency, it may be at a disadvantage in the market competition. Second, market competition. As its prospects gradually brighten, there are many coveting this market, and there are more and more new entrants, and the competition may become more intense. Manufacturers need to make more efforts in quality control, price strategy and innovation ability to stand out.
    Overall, the 2,4,6-trimethylpyridine market has bright prospects and challenges. If companies can gain insight into market changes and focus on technological innovation and cost control, they will be able to take advantage of the trend and occupy a place in the market. The prospects may be optimistic.