2-[{4-(3-Methoxypropoxy)-3-methyl pyridine-2-yl}methylthio]-1H-benzimidazole

When I look at the chemical structure of this question, the formula is slightly complicated. Many groups are mentioned here, such as "methylaminoethoxy" and "methylcarbonyl". To clarify its chemical structure, it is necessary to analyze the relationship between each part.
First look at the formula "2 - [% 5B% 7B4- (3-methylaminoethoxy) -3 -methylcarbonyl - 2 - yl% 7D methylcarboxyl% 5D - 1H -indolopyrazole". "2 -" and "1H -" identify their positions. " Indolopyrazole "is the core structure, like the foundation of a pavilion, laying the framework of the whole.
"% 5B% 7B4- (3-methylaminoethoxy) -3-methylcarbonyl-2-yl% 7D methylcarboxyl% 5D "This part is like the decoration of a pavilion, attached to the core structure. Among them, "4- (3-methylaminoethyloxy) " and "3-methylaminoethyloxy" are connected to the "4" position if the branches stretch; "3-methylcarbonyl" also falls in the corresponding "3" position; "2-group" is also a part of the structure although the group is not specified. "Methyl carboxyl" is connected to the above part to build this complex chemical structure together.
This chemical structure, with "indolopyrazole" as the core, is externally connected with a variety of groups, and each part is connected to each other to form a unique chemical form, just like a delicate ancient building, with beams and columns tenons and mortise, supporting each other, forming an organic whole. In the field of chemistry, it has its unique properties and functions.

1H-benzofuran has the following physical properties: its appearance is mostly colorless to light yellow liquid at room temperature and pressure, and its texture is relatively clear.
In terms of odor, it has a special and relatively weak aromatic smell. This smell is neither rich and pungent nor difficult to detect, and belongs to a relatively unique class of aromatic smell.
The boiling point of 1H-benzofuran is in a specific range, about 173-174 ° C, which indicates that at this temperature, it will change from liquid to gas. Its melting point is relatively low, about -18 ° C, which means that at this temperature, it will solidify into a solid state.
In terms of solubility, 1H-benzofuran is insoluble in water, mainly due to the characteristics of its molecular structure. It belongs to non-polar or weakly polar molecules, while water is a highly polar solvent. According to the principle of similar phase dissolution, the two are difficult to dissolve each other. However, it is soluble in some common organic solvents, such as ethanol, ether, etc. The polarity of these organic solvents is similar to that of 1H-benzofuran, and they can interact with it through intermolecular forces to achieve dissolution.
In addition, the density of 1H-benzofuran is slightly smaller than that of water, which makes it float in the upper layer of water if mixed with water. The steam is heavier than air, and under certain conditions, the steam will spread close to the ground, which requires special attention to ventilation and other safety measures in relevant industrial operations or storage scenarios to prevent the accumulation of steam from causing danger.

2-%5B%7B4-%283-%E7%94%B2%E6%B0%A7%E5%9F%BA%E4%B8%99%E6%B0%A7%E5%9F%BA%29-3-%E7%94%B2%E5%9F%BA%E5%90%A1%E5%95%B6-2-%E5%9F%BA%7D%E7%94%B2%E7%A1%AB%E5%9F%BA%5D-1H-%E8%8B%AF%E5%B9%B6%E5%92%AA%E5%94%91, this is the expression of organic chemical substances. However, in order to clarify its main use, its structure and characteristics need to be analyzed in detail.
2- [{4- (3-methoxyethoxy) -3-methylpyridine-2-yl} methanesulfonyl] -1H-indole, such compounds containing indole structure, are widely used in the field of medicinal chemistry. First, it is often used as a key structural unit of active pharmaceutical ingredients. Because of its unique chemical structure, it can interact with specific biological targets, such as binding with certain proteins and enzymes in the body, to regulate physiological processes. < Br >
Second, in the field of materials science, it also has potential uses. Indole-containing compounds may be used to prepare organic optoelectronic devices, such as organic Light Emitting Diode (OLED) and organic solar cells, due to their special optical and electrical properties. Such compounds may endow materials with unique photoelectric conversion properties and improve device efficiency.
Third, in the field of agriculture, it may be used as a precursor structure for the creation of pesticides. After modification, it may have biological activities such as insecticidal, bactericidal, and weeding, providing a new way for crop protection.
Due to its unique structure, this compound shows potential application value in many fields such as medicine, materials, agriculture, etc. With in-depth research, it is expected to develop more practical products for the benefit of human society.

To prepare 2 - [{4 - (3 - methoxyethoxy) - 3 - methylpyridine - 2 - yl} methanesulfonyl] - 1H - indolopyrazole, you can follow the following ancient method:
Begin with 3 - methylpyridine - 2 - alcohol, and undergo methoxy ethoxylation. In a suitable reactor, put 3 - methylpyridine - 2 - alcohol, add an appropriate amount of base agent, such as potassium carbonate, etc., to assist the reaction. Next, slowly add methoxyethoxylation reagents, such as methoxyethyl halide, control the temperature in a moderate range, usually 50-80 degrees Celsius, and continue to stir for several hours, about 3-6 hours, to obtain 4- (3-methoxyethoxy) -3-methylpyridine-2-ol.
times, the product is sulfonylated. Take an appropriate amount of 4- (3-methoxyethoxy) -3-methylpyridine-2-ol and dissolve it in a suitable organic solvent, such as dichloromethane. After cooling, drop to 0-5 degrees Celsius, add methanesulfonyl chloride dropwise, and add an acid binding agent, such as triethylamine, when reacting for about 2-4, to obtain {4- (3-methoxyethoxy) -3 -methylpyridine-2-yl} methanesulfonyl derivatives.
, react with 1H-indolopyrazole parent. 1H-indolopyrazole is placed in the reaction system, and an appropriate amount of base and catalyst, such as copper salt catalyst, is added. At an appropriate temperature, 80-120 degrees Celsius, the reaction is 8-12. After separation and purification, such as column chromatography, 2- [{4- (3-methoxyethoxy) -3-methylpyridine-2-yl} methanesulfonyl] -1H-indolopyrazole can be obtained. < Br >
During this period, each step of the reaction requires careful control of the conditions, attention to the ratio of raw materials, temperature, and reaction time, and the detection and analysis of the product to ensure that the reaction is smooth and the product is pure.

2-%5B%7B4-%283-%E7%94%B2%E6%B0%A7%E5%9F%BA%E4%B8%99%E6%B0%A7%E5%9F%BA%29-3-%E7%94%B2%E5%9F%BA%E5%90%A1%E5%95%B6-2-%E5%9F%BA%7D%E7%94%B2%E7%A1%AB%E5%9F%BA%5D-1H-%E8%8B%AF%E5%B9%B6%E5%92%AA%E5%94%91, make this thing, pay attention to all things.
First of all, it should be clear about its nature. 2-%5B%7B4-%283-%E7%94%B2%E6%B0%A7%E5%9F%BA%E4%B8%99%E6%B0%A7%E5%9F%BA%29-3-%E7%94%B2%E5%9F%BA%E5%90%A1%E5%95%B6-2-%E5%9F%BA%7D%E7%94%B2%E7%A1%AB%E5%9F%BA%5D-1H-%E8%8B%AF%E5%B9%B6%E5%92%AA%E5%94%91 sensitive, easy to respond to other things. In case of heat, light or some agents, its change or drama, so when storing, it should be placed in a yin, dry and cool place, avoid mixing with strong oxygen agents, acids and alkalis.
When operating, you must obey the law. Keep suitable protective gear, such as gloves and eyepieces, to prevent contact with the body or splashing eyes. Liquid mixing and other operations should be carried out in a good place, according to the rules and order, and the stirring should be slowed down to avoid life insurance.
Furthermore, pay attention to its waste. After use, the residue should not be discarded indiscriminately, and it should be handled according to the ring regulations to prevent pollution. If it can be collected, it should be collected according to the method, so that it can be reused.
In addition, if there is any doubt or abnormality in the middle, stop the operation quickly and consult the specialist. And when the level is stored, it should be checked regularly to observe whether its state and quality have changed, so as to ensure its stability. In this way, the 2-%5B%7B4-%283-%E7%94%B2%E6%B0%A7%E5%9F%BA%E4%B8%99%E6%B0%A7%E5%9F%BA%29-3-%E7%94%B2%E5%9F%BA%E5%90%A1%E5%95%B6-2-%E5%9F%BA%7D%E7%94%B2%E7%A1%AB%E5%9F%BA%5D-1H-%E8%8B%AF%E5%B9%B6%E5%92%AA%E5%94%91 is safe, and the environment and people's health are protected.