2-(3-Hydroxypropyl)pyridine

2-%283+-+Hydroxypropyl%29pyridine is 2- (3-hydroxypropyl) pyridine, which has a wide range of uses. In the field of medicine, it is a key intermediate and can participate in the synthesis of a variety of drugs. The structure of the Gein pyridine ring has unique chemical activity. When combined with hydroxypropyl, it can endow drugs with specific properties and functions, such as improving drug solubility, stability, and bioavailability.
In the field of materials science, 2- (3-hydroxypropyl) pyridine also has important uses. It can be used to prepare functional polymer materials. It can be used as a polymerization monomer or modifier to introduce specific functional groups to the polymer chain, imparting materials with unique properties such as hydrophilicity and biocompatibility. It is used in membrane materials, adsorption materials, etc.
Furthermore, in the field of organic synthesis chemistry, it is an important building block for organic synthesis. With its structure of pyridine ring and hydroxypropyl group, it can construct more complex organic compounds through various chemical reactions, such as substitution reaction, condensation reaction, etc., providing organic synthesis chemists with a variety of synthetic paths, and assisting in the creation and development of new compounds. In short, 2 - (3 - hydroxypropyl) pyridine plays an indispensable role in many fields such as medicine, materials, and organic synthesis.

2-%283+-+Hydroxypropyl%29pyridine is 2- (3 -hydroxypropyl) pyridine, the physical properties are as follows:
It is an organic compound, at room temperature, or in a colorless to light yellow liquid state, with a clear and transparent appearance. It has a special smell, but its taste is difficult to be liked by ordinary people, and it is slightly uncomfortable to smell.
In terms of solubility, it can show a certain solubility in water, and it can also be miscible with many organic solvents such as ethanol and ether. This property is derived from the polar groups contained in its molecular structure, which makes it possible to form suitable interactions with polar or non-polar solvents.
When it comes to the boiling point, it is within a certain temperature range. The specific value of this temperature is determined by the intermolecular forces. Interactions such as hydrogen bonds and van der Waals forces exist between molecules, which require specific energies to overcome these forces and reach the boiling state. Its melting point also has a specific value, reflecting the temperature conditions required to transition from a solid state to a liquid state.
The density of 2 - (3-hydroxypropyl) pyridine may be different from that of water, depending on its molecular mass and the way the molecules are deposited. And because of the presence of pyridine ring and hydroxypropyl group in its structure, it is endowed with certain chemical activity, and can be used as a key intermediate in the field of organic synthesis, participating in a variety of chemical reactions, providing the possibility for the preparation of more complex organic compounds.

2-%283+-+Hydroxypropyl%29pyridine is 2- (3-hydroxypropyl) pyridine. The chemical properties of this substance are quite stable.
Looking at its structure, the pyridine ring is an aromatic heterocycle with certain stability. The nitrogen atom on the ring has lone pair electrons, which can participate in various reactions, but it also changes the electron cloud density distribution of the pyridine ring, which stabilizes the entire molecular structure to a certain extent. Its 2-linked (3-hydroxypropyl) group, the hydroxyl group can form hydrogen bonds, increase the intermolecular force, and contribute to its stability. Propyl provides a certain flexibility and steric resistance to the molecule.
From the perspective of reactivity, the pyridine ring can undergo electrophilic substitution reaction, but due to the electron-absorbing effect of nitrogen atoms, the reactivity is lower than that of benzene, and the reaction check points are mostly at the 3 and 5-position. This characteristic limits the type and degree of reaction, and the side reflects its stability. Although hydroxyl groups have certain reactivity and can undergo esterification, oxidation and other reactions, under suitable conditions, these reactions are controllable and the molecule as a whole can remain relatively stable.
Under common environmental conditions, without special reagents and conditions, 2- (3-hydroxypropyl) pyridine can maintain structural stability and is not prone to spontaneous decomposition or other violent changes.

The synthesis method of 2 - (3 -hydroxypropyl) pyridine, as described in the ancient books, has many paths. First, pyridine is used as the starting material and obtained by nucleophilic substitution reaction. In suitable solvents, pyridine and 3-halopropanol undergo nucleophilic substitution under the action of bases. Bases can be selected from potassium carbonate, sodium hydroxide, etc., and solvents can be selected from dimethylformamide, acetonitrile, etc. This reaction condition needs to be carefully controlled, and the temperature is usually maintained in a moderate range. If the temperature is too high, side reactions are prone to occur, resulting in impaired product purity; if the temperature is too low, the reaction rate is slow and takes a long time.
Second, it can be achieved through the reduction reaction of pyridine derivatives. Pyridine derivatives containing suitable substituents are first prepared, and then specific functional groups are reduced to 3-hydroxypropyl groups by reducing agents such as sodium borohydride and lithium aluminum hydride. However, lithium aluminum hydride has high activity, and the reaction operation needs to be carried out in a harsh environment without water and oxygen to prevent its violent reaction and cause danger. Sodium borohydride is relatively mild, but its reducing ability is also limited, and it needs to be carefully selected according to the characteristics of the substrate.
In addition, there are also methods for reacting with pyridine with 3-hydroxypropylation reagents. This 3-hydroxypropylation reagent can be a compound with specific activity and react with pyridine in the presence of a catalyst. The choice of catalyst is crucial, and different catalysts have a significant impact on the reaction activity and selectivity. Some metal salt catalysts or organic base catalysts may be used in this reaction system, but the best catalyst and dosage need to be explored through experiments. There are many methods for synthesizing 2- (3-hydroxypropyl) pyridine, each with its advantages and disadvantages. In practical application, it is necessary to comprehensively consider many factors such as raw material availability, cost, reaction conditions and product purity, and carefully choose the appropriate synthesis path.

The price of 2 - (3 -hydroxypropyl) pyridine is confirmed in the market. The price of these chemical materials often varies due to factors such as market conditions, supply and demand, quality, source, purchase quantity, etc.
If the quantity is purchased in small quantities, from the chemical reagent supplier, the price may vary due to different grades. Analytically pure, the price may be higher; for industrial grade, the price may be slightly lower. If the quantity is small and the reagent grade is purchased, the price per gram may vary from a few yuan to tens of yuan.
However, if it is purchased in large quantities for industry, the price may vary. The larger the purchase quantity, the lower the price per unit may be. If you buy hundreds of kilograms or even several tons, the supplier may give a preferential price due to cost considerations, market competition, etc., or about 100 yuan per kilogram, or lower, which is difficult to determine.
And the market changes, sometimes raw materials are in short supply, and prices rise; sometimes oversupply, prices may fall. To know the exact market price of 2 - (3-hydroxypropyl) pyridine, when consulting chemical raw material suppliers, traders, or checking the real-time market of chemical product trading platforms, you can get a near-real price.