2 3 Difluoropyridine
pyridine pyrrole pyrazine piperidine piperazine

2,3-difluoropyridine

    Specifications

    HS Code

    218249

    Chemical Formula C5H3F2N
    Molecular Weight 113.08
    Appearance Colorless to light yellow liquid
    Boiling Point 136 - 138 °C
    Melting Point -26 °C
    Density 1.272 g/mL at 25 °C
    Flash Point 37 °C
    Solubility In Water Insoluble
    Vapor Pressure 1.62 mmHg at 25 °C
    Refractive Index 1.463

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    General Information
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    Frequently Asked Questions

    As a leading 2,3-difluoropyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2,3-difluoropyridine?
    2% 2C3-diethoxyethane, also known as ethylene glycol diethyl ether, has the following main uses:
    This substance has many applications in the industrial field. It is an important solvent and intermediate in organic synthesis. Because of its good solubility, it can dissolve many organic compounds, such as resins, rubbers, cellulose esters, etc., it is often selected as a solvent in the manufacture of coatings, inks, adhesives and other products. With its solubility characteristics, it can make various ingredients uniformly mixed, greatly improving product quality and performance.
    In the process of organic synthesis, 2% 2C3-diethoxyethane plays a key role as an intermediate. For example, in some etherification reactions, it can participate in the reaction to form new carbon-oxygen bonds, and then synthesize organic compounds with specific structures and functions. These compounds are widely used in the production of fine chemical products such as pharmaceuticals and pesticides. For example, in some drug synthesis routes, it is used to participate in the reaction to help build key molecular structures and achieve the preparation of pharmaceutical active ingredients.
    In addition, in some extraction processes, 2% 2C3-diethoxyethane can be used as an extractant to separate and purify target substances from mixtures due to its specific miscibility with water and some organic solvents. In chemical production, the target product can be effectively extracted from the reaction system or complex mixture through extraction operations to improve the purity of the product.
    In summary, 2% 2C3-diethoxyethane, with its unique physical and chemical properties, plays an important role in many fields such as organic synthesis, coatings and inks, fine chemicals, and extraction and separation. It is of great significance to industrial production and scientific research.
    What are the synthesis methods of 2,3-difluoropyridine?
    2% 2C3-diethoxyethane, also known as acetal, has many synthesis methods, which are described in detail today.
    First, acetaldehyde and ethanol are used as raw materials and can be synthesized under the action of acidic catalysts. The reaction mechanism is: the carbonyl group of acetaldehyde is protonated by acid to enhance its electrophilicity, the hydroxyl oxygen atom of ethanol is rich in electrons, and the nucleophilic attacks the protonated carbonyl carbon to form a hemiacetal intermediate. This intermediate is then transferred and dehydrated by protons, and then reacts with another molecule of ethanol to eventually produce 2% 2C3-diethoxyethane. Common acidic catalysts include sulfuric acid, p-toluenesulfonic acid, etc. The raw materials of this method are easy to obtain, and the reaction conditions are relatively mild. However, attention needs to be paid to controlling the reaction temperature and catalyst dosage to prevent side reactions, such as the polymerization of acetaldehyde.
    Second, ethylene is used as the starting material, and ethylene oxide is first oxidized to form ethylene oxide, and then ethylene oxide is reacted with ethanol under the action of a catalyst. The oxidation of ethylene to ethylene oxide is usually carried out with a silver catalyst at a specific temperature and pressure. For the reaction of ethylene oxide with ethanol, the catalyst can be Lewis acid or base, such as boron trifluoride ethyl ether complex, sodium hydroxide, etc. This route process is relatively complicated, but ethylene comes from a wide range of sources and has great potential from the perspective of industrial production.
    Third, it is prepared by the alcoholysis reaction of ethyl acetate and ethanol under the action of metal alk During the reaction, the ethoxy group of ethyl acetate is replaced by the ethoxy group of ethanol to form 2% 2C3-diethoxyethane and acetic acid. Metal alkoxides such as sodium ethanol can effectively catalyze this reaction. This method is common in raw materials, but the separation and purification of the product may require fine operation to obtain high purity 2% 2C3-diethoxyethane.
    What is the market outlook for 2,3-difluoropyridine?
    In today's world, 2,3-diethoxybenzaldehyde is in the market, and its scenery is quite good. Looking at various chemical substances, this is a widely used raw material, and it is used in medicine, fragrance, pesticide and other industries.
    In the field of medicine, it can be used as an intermediate for various medicines. With its structural characteristics, it can participate in a variety of chemical reactions and assist in the synthesis of drugs. For example, in the preparation of some antibacterial drugs, it can be used as a starting material. After several steps of reaction, it can obtain a curative ingredient.
    In the fragrance industry, it also has something extraordinary. Because of its unique aroma, it can be used as a raw material for fragrance blending. It can add a different flavor to the fragrance, making the aroma richer and more charming. The perfumer often uses the layered sense of fragrance to form a unique fragrance, and uses various perfumes, air fresheners and other substances.
    In the production of pesticides, 2,3-diethoxybenzaldehyde can also be used as much as possible. It can be used as an intermediate for the production of some high-efficiency and low-toxicity pesticides. It helps to form pesticides with insecticidal, bactericidal and other effects, to protect the growth of agricultural products, and to increase the amount of agricultural production.
    Looking at the needs of the city, with the rise of medicine, fragrances, pesticides and other industries, its demand is also increasing. The development of various industries has promoted its wide use. In addition, with the advance of technology, its synthesis method has also become better, the yield has increased and the cost has decreased, and it has also promoted its circulation in the market.
    From this perspective, 2,3-diethoxybenzaldehyde has broad prospects in the market and plays an indispensable role in the development of various industries. In the future, it will also gain more opportunities and development with the progress of various industries.
    What are the physical and chemical properties of 2,3-difluoropyridine?
    2% 2C3 -diethoxyethane, which is like a colorless and transparent liquid with a special odor of ethers, is quite common in the chemical industry.
    Looking at its physical properties, the boiling point is about 101.5 ° C. At this temperature, the substance changes from liquid to gaseous state, just like ice melts water when it meets warm sun. The melting point is -74 ° C. When the temperature drops to this temperature, it gradually solidifies from a flowing state, just like a stream freezes in winter. The density is about 0.831g/cm ³, which is lighter than water. If it is poured into water, it will float on the water surface, just like wood leaves in rivers. It is also slightly soluble in water, but it can be miscible with organic solvents such as alcohols and ethers, just like salt mixed with water, immiscibly.
    In terms of its chemical properties, 2% 2C3-diethoxyethane has ether-like commonality due to its ether bond. Its chemical properties are relatively stable, and under normal conditions, it is not easy to react with many substances. It is like a superhero hidden in the world, and it is not easy to dispute with the outside world. When encountering strong oxidants, such as concentrated sulfuric acid and concentrated nitric acid, it will react, or cause ether bonds to break, resulting in different products. And because of its flammability, it is very easy to burn in case of open fire and hot topic, just like dry wood meets fire, and instantly ignites a raging flame. When using it, be sure to be careful and strictly observe safety to prevent the birth of fire.
    What are the precautions for using 2,3-difluoropyridine?
    2% 2C3 -diethoxyethane is an organic compound. During use, many precautions must be kept in mind.
    First, fire and explosion protection are essential. This compound is flammable, and steam and air can form explosive mixtures. Therefore, the place of use must be kept away from fire and heat sources, and smoking is strictly prohibited. Explosion-proof electrical equipment and tools should be used during operation to prevent sparks from causing explosions.
    Second, pay attention to its toxicity. Although the toxicity is relatively low, inhalation, ingestion or skin absorption may still pose a health hazard. Workplaces should be well ventilated, and operators should wear appropriate protective equipment, such as gas masks, protective gloves, safety glasses, etc., to avoid contact.
    Third, the storage conditions should not be ignored. It should be stored in a cool and ventilated warehouse, away from fire and heat sources. The storage temperature should not exceed 37 ° C. Keep the container sealed. Do not mix with oxidants, acids, etc. to prevent chemical reactions.
    Fourth, precisely control the dosage and reaction conditions during use. Due to its active chemical properties, improper reaction conditions can easily cause side reactions, affecting product quality and yield. Therefore, it is necessary to strictly follow the operating procedures to accurately control factors such as temperature, time, and proportion of reactants.
    Fifth, emergency treatment should also be known. In the event of a leak, personnel from the leaked contaminated area should be quickly evacuated to a safe area, quarantined, and strictly restricted access. To cut off the fire source, emergency personnel wear self-contained positive pressure breathing apparatus and fire protection clothing to cut off the leakage source as much as possible to prevent it from flowing into the restricted space such as sewers and drainage ditches. Small leaks are adsorbed or absorbed by sand or other non-combustible materials, and large leaks are built into embankments or excavated for containment, covered with foam to reduce steam disasters, and transferred to a tanker or special collector with an explosion-proof pump for recycling or transportation to a waste treatment site for disposal.