2 3 Difluoropyridine 4 Carboxylic Acid
pyridine pyrrole pyrazine piperidine piperazine

2,3-Difluoropyridine-4-carboxylic acid

    Specifications

    HS Code

    960945

    Chemical Formula C6H3F2NO2
    Molar Mass 159.09 g/mol
    Appearance Solid (usually white or off - white)
    Melting Point 147 - 151 °C
    Solubility In Water Slightly soluble, due to the hydrophobic nature of the fluorinated pyridine ring and the hydrophilic carboxylic acid group
    Solubility In Organic Solvents Soluble in polar organic solvents like DMSO, DMF
    Pka Carboxylic Acid Group Around 3 - 4 (typical for aromatic carboxylic acids)
    Odor Odorless or has a faint, characteristic aromatic odor

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    General Information
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    Frequently Asked Questions

    As a leading 2,3-Difluoropyridine-4-carboxylic acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2,3-difluoropyridine-4-carboxylic acid?
    2% 2C3-diethoxytoluene-4-carboxylic acid is a crucial raw material in organic synthesis and has been widely used in many fields.
    First, in the field of medicinal chemistry, this compound is a key intermediate for the synthesis of many drugs. Due to its specific chemical structure, other functional groups can be introduced through a series of chemical reactions, and then molecular structures with specific pharmacological activities can be constructed. For example, some drugs used in the treatment of cardiovascular diseases may be synthesized with 2% 2C3-diethoxytoluene-4-carboxylic acid as the starting material. After ingenious chemical modification, drug molecules with targeted effects and effective regulation of cardiovascular physiological functions can be prepared.
    Second, in the field of materials science, it can participate in the synthesis of high-performance materials. Polymer materials with special properties can be prepared by polymerization with other monomers. Such materials may have good thermal stability, mechanical properties, etc., and have broad application prospects in high-end fields such as aerospace and electronic devices. For example, in the aerospace field, the synthesized materials can be used to manufacture aircraft parts. With its excellent performance, the safety and reliability of aircraft are improved.
    Third, in the field of fine chemicals, 2% 2C3-diethoxytoluene-4-formic acid is often used as an important raw material for the synthesis of special fragrances and dyes. Due to its unique chemical structure, it can give the fragrance a unique smell, or make the dye have better dyeing performance and color fastness. For example, in high-end fragrance formulations, adding perfume ingredients synthesized from this raw material can create a unique and lasting aroma atmosphere; in the dye industry, dyes suitable for high-end fabric dyeing can be prepared to meet the market demand for high-quality dyes.
    What are the physical properties of 2,3-difluoropyridine-4-carboxylic acid?
    2% 2C3-diethoxybutyl-4-enoic acid is a class of organic compounds. Its physical properties are quite unique and are described as follows:
    First of all, its phase state and color, at room temperature, often colorless to pale yellow liquid, clear texture, quite fluidity. The appearance of this form is actually determined by its molecular structure and intermolecular forces. The various atoms in the molecule are connected by specific chemical bonds to form a specific spatial configuration, resulting in an equilibrium of the attractive force and repulsion between molecules, so it presents this phase state.
    Second and odor, with a weak and specific aroma. The source of this odor is due to the specific functional groups contained in the molecule, such as ester groups, whose vibrational frequencies interact with human olfactory receptors, resulting in this unique olfactory sensation.
    Furthermore, on its boiling point. In an atmospheric pressure environment, the boiling point is about a specific temperature range, which reflects the energy required for the molecule to leave the liquid phase and become the gas phase. Because there are forces such as van der Waals forces between molecules, if you want to make it boil, you must supply enough energy to overcome these forces. The ethoxy groups and other parts of its molecular structure increase the interaction between molecules, so the boiling point is at a corresponding level.
    As for the melting point, it is also in a specific low temperature range. The level of melting point is related to the close arrangement of molecules and the strength of interaction. When the molecules of this compound are in a solid state, they are arranged according to certain rules, and the forces between them maintain their lattice structure. When the temperature rises to the melting point, the lattice structure disintegrates and then melts into a liquid state.
    In terms of solubility, it has good solubility in common organic solvents such as ethanol and ether. This is due to the principle of "similar miscibility". There are similar polarities or intermolecular forces between the compound molecules and the organic solvent molecules, and they are easy to intersperse and mix with each other, thus showing good solubility. However, in water, its solubility is relatively limited. Because the overall polarity of the molecule is not highly matched with water, the interaction between water molecules and the compound molecules is weak, so it is difficult to dissolve in water.
    These are the general physical properties of 2% 2C3-diethoxybutyl-4-enoic acid, which is an important content of organic chemistry research and is of crucial significance for its exploration in the fields of synthesis, separation and application.
    What are the chemical synthesis methods of 2,3-difluoropyridine-4-carboxylic acid?
    The synthesis of 2% 2C3-diethoxybutyl-4-enoic acid is an interesting topic in organic synthetic chemistry. There are many methods for its synthesis, each with its own advantages. I will describe it in detail for you.
    First, the key intermediates can be obtained after the condensation reaction of hydroxyaldehyde with aldose and ketone as starting materials. In this reaction, aldose and ketone condensate under the action of basic catalysts to form unsaturated carbonyl compounds. Then, through etherification, ethoxy groups are introduced to achieve the synthesis of the target product. The advantage of this approach is that the raw materials are common and easy to obtain, and the reaction steps are relatively clear. However, the control requirements for the reaction conditions are quite high. The amount of alkaline catalyst and the reaction temperature need to be precisely controlled to improve the yield and purity of the product.
    Second, malonate esters can be used to introduce corresponding alkyl groups through alkylation to build a carbon chain skeleton. Then, through a series of reactions such as hydrolysis and decarboxylation, the target 2% 2C3-diethoxybutyl-4-enoic acid is finally generated. The beauty of this method is that the reaction route is relatively simple and the selectivity of each step is also good. However, the cost of malonic acid esters may be higher, and some reaction steps need to be carried out under specific solvents and conditions, which makes the operation slightly complicated.
    Third, the compound can also be synthesized by using ethyl acetoacetate as the starting material through a series of substitution, condensation and decarboxylation reactions. This strategy cleverly uses the active methylene of ethyl acetoacetate to introduce the desired group through substitution reaction with reagents such as halogenated hydrocarbons. Then the double bond structure is constructed through condensation reaction, and finally the target product is decarboxylated. The reaction conditions of this path are relatively mild, and some reactions can be completed under conventional laboratory conditions, but the overall reaction steps are slightly more, and the reaction of each step needs to be carefully planned to ensure the quality of the product.
    The above methods have their own advantages and disadvantages. In the actual synthesis process, it is necessary to carefully select the appropriate synthesis method according to many factors such as the availability of raw materials, cost considerations, difficulty in controlling reaction conditions, and requirements for product purity, so as to achieve the purpose of efficient and high-quality synthesis of 2% 2C3-diethoxybutyl-4-enoic acid.
    What is the price of 2,3-difluoropyridine-4-carboxylic acid in the market?
    In today's market, the price of 2,3-diallyl-4-valerynic acid is difficult to determine. The price of the cover often changes for various reasons.
    First, it is related to the supply and demand of this thing. If there are many people who want it, but there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price will be depressed.
    Second, the price of raw materials is also a factor. The preparation of this acid requires specific raw materials. If the price of raw materials is high, the cost of this acid will increase, and its price will also rise; if the price of raw materials falls, the cost will decrease, and the price may also decrease.
    Third, the difficulty and advanced of the process also affect the price. If the preparation method is complicated and requires a lot of manpower and material resources, the price will be high; if there is a new and clever method that can reduce its cost, the price may be reduced.
    Fourth, the chaos of the market and the competition of merchants are all related to the price. In times of peace, the competition of merchants is orderly, and the price may be stable; if the market is turbulent and merchants dispute for profits, the price may fluctuate.
    Therefore, in order to know the exact price of 2,3-diallyl-4-valerynic acid in the market, it is impossible to generalize when examining the market conditions, the price of raw materials, changes in technology, and the state of merchants.
    What are the storage conditions for 2,3-difluoropyridine-4-carboxylic acid?
    The storage conditions of 2% 2C3-diethoxytoluene-4-carboxylic acid depend on its properties. This substance has certain chemical activity and is quite sensitive to changes in temperature and humidity.
    Store in a cool and dry place. If it is in a wet environment, it is easy to cause hydrolysis and other chemical changes, which will damage its quality. The temperature should be controlled at 2-8 ° C. If it is too high, the molecular activity may be too strong, causing decomposition or polymerization, and reducing its purity. If it is too low, it may cause crystalline deformation, and it is also unfavorable to exist.
    And it should be avoided from mixing with strong oxidants, strong bases, etc., because of its chemical activity and activity. If it encounters it, it is easy to cause reactions and be dangerous. The storage device should be corrosion-resistant and airtight, such as glass bottles or special plastic devices, which can prevent contact with foreign objects and cause changes, and also ensure the stability of its quality.
    The storage place must be well-kept to prevent the accumulation of volatile gas and reduce safety hazards. It is also necessary to check its storage status frequently to see if there is any color change, taste change or phase change. If so, it indicates that the quality has changed or has changed, and do not use it again. In this way, the quality of 2% 2C3-diethoxytoluene-4-carboxylic acid can be preserved for later use.