2 3 Difluoro 5 Trifluoromethyl Pyridine
pyridine pyrrole pyrazine piperidine piperazine

2,3-Difluoro-5-(trifluoromethyl)pyridine

    Specifications

    HS Code

    387337

    Chemical Formula C6H2F5N
    Molecular Weight 183.08
    Appearance Typically a colorless to pale - yellow liquid
    Boiling Point Around 125 - 127 °C
    Solubility Soluble in many organic solvents like dichloromethane, toluene
    Vapor Pressure Depends on temperature, relatively low for a liquid of this size
    Stability Stable under normal conditions, but reactive with strong oxidizing agents

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    General Information
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    Frequently Asked Questions

    As a leading 2,3-Difluoro-5-(trifluoromethyl)pyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2,3-difluoro-5- (trifluoromethyl) pyridine?
    2% 2C3-diene-5- (trienomethyl) pyridine is a key intermediate in organic synthesis. It has important uses in many fields.
    In the field of medicinal chemistry, it can be used as a raw material to construct complex molecular structures with specific biological activities through various reaction pathways. By modifying and transforming its functional groups, it is expected to synthesize drug molecules targeting specific disease targets, such as anti-tumor and antiviral drugs. Due to the wide presence of pyridine ring structures in many active pharmaceutical ingredients, this compound can be used as a key building block to lay the foundation for the development of new drugs.
    In the field of materials science, 2% 2C3-diene-5- (trienomethyl) pyridine can participate in the synthesis of polymer materials. With its unsaturated double bonds and other active checking points, it can polymerize with other monomers, endowing the material with unique optical and electrical properties. For example, the preparation of polymer materials with fluorescent properties may have applications in photoelectric display, sensors, etc.
    In the field of organic synthesis chemistry, as a key intermediate, it can derive a series of organic compounds with different structures through various organic reactions, such as nucleophilic substitution, electrophilic addition, etc., which greatly enriches the types of organic compounds and promotes the development of organic synthesis methodologies.
    In conclusion, 2% 2C3-diene-5- (trienomethyl) pyridine plays an important role in many fields such as medicine, materials, and organic synthesis, providing an important material basis for innovation and development in related fields.
    What are the physical properties of 2,3-difluoro-5- (trifluoromethyl) pyridine?
    2% 2C3-diene-5- (trienomethyl) pentene This substance has unique physical properties and is worth exploring.
    Looking at its shape, under room temperature, or a colorless and transparent liquid, the texture is light and flowing freely, like smart water, but it has its own characteristics. Close to the smell, or there is a light smell, not pungent and intolerable, but like a subtle fusion of natural smells, which is fascinating.
    When it comes to density, it is lighter than water, so if it is placed with water, this object will float leisurely on the water surface, just like a light boat floating on the blue waves. Its boiling point also has a fixed number. When the external temperature rises to a specific value, it will boil and transform into a gaseous state. This temperature may be in a certain range, which shows its unique boiling point characteristics compared with many similar substances.
    As for solubility, it may have good solubility in organic solvents. Common organic solvents such as ethanol and ether, when they meet, it is like an old friend reuniting, and they can quickly blend and mix into one. However, in water, the solubility is not good, and the two are difficult to integrate intimately. They are often in a layered state, one up and one down, and the boundaries are clear.
    Its volatility cannot be underestimated. In an open environment, it will slowly evaporate and gradually dissipate into the air. Like the morning fog in spring, as the sun shines, it gradually fades away. This volatility makes it necessary to pay special attention when storing and using this substance, and keep it properly to prevent it from evaporating too quickly and being lost.
    In summary, 2% 2C3-diene-5- (trienyl methyl) pentene shows its own unique appearance in terms of physical properties such as morphology, density, boiling point, solubility and volatility, and occupies a unique place in the world of chemical substances.
    What are the chemical properties of 2,3-difluoro-5- (trifluoromethyl) pyridine?
    2% 2C3-diene-5- (trienomethyl) pyridine, an organic compound. Its chemical properties are quite unique, containing a conjugated diene structure, which endows it with certain reactivity. The conjugated system extends the distribution of electron clouds and can participate in many electron transfer and addition reactions.
    The pyridine ring in this compound has a nitrogen atom and is basic. Due to the presence of lone pairs of electrons on the nitrogen atom, it can interact with protons or electrophilic reagents. The presence of pyridine rings also affects the electron cloud distribution and spatial structure of the molecule, thereby affecting the reactivity and selectivity of the whole compound.
    In the electrophilic addition reaction, the 2,3-diene part can be used as the reaction check point. In view of the conjugation effect, electrophilic reagents tend to be added to the conjugated system to form stable intermediates. The nitrogen atom on the pyridine ring will affect the electron cloud density of the diene part due to induction and conjugation effects, which will affect the regioselectivity of the electrophilic addition.
    In the nucleophilic substitution reaction, if the pyridine ring is connected to a suitable leaving group, the nucleophilic reagent can attack the pyridine ring and cause a substitution reaction. The basicity of the pyridine ring and the electronic effect of the substituent will affect the rate and selectivity of the nucleophilic substitution reaction.
    In addition, the carbon-carbon double bond of the triene methyl part in this compound is also reactive and can participate in addition and oxidation reactions. The interaction between the triene methyl and the diene and pyridine rings will affect the chemical properties and reaction pathways of the entire molecule. For example, the steric hindrance effect restricts the proximity of the reaction reagents, which in turn affects the rate of reaction and the selectivity of the product.
    What are the synthesis methods of 2,3-difluoro-5- (trifluoromethyl) pyridine?
    The synthesis of 2% 2C3-diethyl-5- (triethyl) pyridine can be achieved by the following methods.
    First, pyridine is used as the starting material. Under appropriate reaction conditions, pyridine undergoes a nucleophilic substitution reaction with halogenated ethane, and ethyl groups are introduced into the pyridine ring at the 2nd and 3rd positions to form 2,3-diethylpyridine. Subsequently, 2,3-diethylpyridine is reacted with a reagent containing triethyl methyl groups in the presence of a suitable catalyst at a specific temperature and reaction time to obtain the target product 2,3-diethyl-5- (triethylmethyl) pyridine. In this process, the choice of halogenated ethane, the nature of the reaction solvent, and the type and amount of catalyst all have a significant impact on the yield and selectivity of the reaction.
    Second, other pyridine derivatives with suitable substituents can be started. If the starting pyridine ring already has some of the desired substituents, the remaining ethyl groups and triethyl groups can be gradually introduced by rationally designing the reaction route. For example, if there is already an ethyl group on the pyridine ring, it can be converted to a specific functional group first, so that it has an activity check point for reaction with halogenated ethane or triethyl-containing reagents, and then subsequent reactions can be carried out in sequence. This method requires precise control of the reaction conditions at each step to ensure that the reaction proceeds according to the expected path and avoids unnecessary side reactions.
    Third, the reaction strategy of transition metal catalysis is used. Transition metal catalysts such as palladium and nickel exhibit excellent catalytic performance in organic synthesis. In the synthesis of this compound, organic fragments containing ethyl groups and triethylmethyl groups can be connected to the pyridine ring by the coupling reaction catalyzed by transition metals. This method usually has the advantages of mild reaction conditions and high selectivity, but the purity of the catalyst and the anhydrous and oxygen-free reaction system are more stringent to ensure the efficient progress of the catalytic reaction.
    What is the price range of 2,3-difluoro-5- (trifluoromethyl) pyridine in the market?
    What is the market price of 2,3-diethyl-5- (triethylmethyl) pyridine today? This question is also because I want to know the market price of this thing in the market.
    However, the price of the market often changes for various reasons, and it is difficult to determine. First, the price varies depending on the producer, and the technology and origin are also different. Those who are good at making can reduce their cost by clever methods, and the price may be slightly lower; and those who are poor in technique and high in cost will be expensive. Second, the situation of asking for supply is also related to its price. If there are many people who ask, the supply will be few, and the price will increase; on the contrary, if you ask for thin supply and abundant supply, the price will be suppressed. Third, the quality is also the main reason for the price. For those who are of high quality, the price should be high; for those who are of poor quality, the price should be low.
    In addition, the amount purchased is also related to the price. For those who buy a large quantity, the business may be profitable, and the price may be slightly reduced to promote it; for those who buy a small quantity, the price may be as usual.
    Therefore, in order to determine the price of 2,3-diethyl-5- (triethyl methyl) pyridine, it is necessary to carefully consider the situation of the product, demand, supply, quality and purchase quantity. Roughly speaking, in today's city, the price ranges from tens to hundreds of dollars per gram, but this is only an approximation. The truth must be determined by carefully observing the market situation.