2,3-Dichloro-5-(hydroxymethyl)pyridine

2% 2C3-dihydro-5- (furfuryl methyl) pyridine, which has a wide range of uses. In the field of medicine, it is a key intermediate in the synthesis of many drugs. For example, in the preparation of some antihistamines, with its unique chemical structure and specific reaction steps, it can effectively build a drug active molecular skeleton and help the drug achieve anti-allergic effect.
In the field of pesticides, 2% 2C3-dihydro-5- (furfuryl methyl) pyridine also plays an important role. It can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. By reacting with other chemicals, pesticide products with good insecticidal and bactericidal properties can be generated, which makes significant contributions to the control of crop diseases and insect pests.
In the field of materials science, it can participate in the synthesis of some functional materials. For example, polymerization with specific polymer monomers imparts special electrical and optical properties to materials, which are used in electronic devices, optical materials and other fields. Due to the pyridine ring and furfuryl methyl part in the structure, it can bring unique physical and chemical properties to materials and expand the application range of materials.

To prepare 2,3-difluoro-5- (cyanomethyl) pyridine, there are various methods for its synthesis.
First, it can be started from a pyridine derivative. First, take a suitable pyridine substrate and introduce cyanomethyl at a specific position. This step can be achieved by a nucleophilic substitution reaction, in which a cyanomethyl-containing reagent reacts with a pyridine substrate under suitable conditions, or under the catalysis of a base, so that the cyanomethyl reagent is substituted with the halogen atom on the pyridine. Then, a specific position on the pyridine ring is fluorinated. The fluorination step can use a nucleophilic fluorination reagent, and under appropriate solvent and reaction conditions, the fluorine atom is selectively introduced into the desired position to obtain the target product.
Second, the strategy of constructing a pyridine ring can be used. Using small molecules containing fluorine and cyanomethyl as raw materials, the pyridine ring is constructed through multi-step reaction. For example, the condensation reaction of fluorine-containing aldodes, ketones and cyanomethyl-containing amines first occurs to form the skeleton of the pyridine ring, and then it is modified and optimized to ensure that the position of the fluorine atom and cyanomethyl on the pyridine ring meets the requirements of the target product.
Third, metal catalysis can also be used. Metal catalysts, such as palladium and copper, are used to promote the coupling reaction of fluorine-containing reagents with pyridine and cyanomethyl-containing substrates. This method can precisely introduce fluorine atoms and cyanomethyl groups into the pyridine ring, and can be carried out under relatively mild reaction conditions to improve the selectivity and yield of the reaction. However, the metal catalysis method requires quite high requirements on the selection of catalysts and the control of reaction conditions, and requires fine regulation to achieve the best effect.
There are various methods for synthesizing 2,3-difluoro-5- (cyanomethyl) pyridine, and each method has its own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as the availability of raw materials, the difficulty of reaction and cost to choose the optimal synthesis path.

2% 2C3 -dideuterium-5- (methoxy) pyridine is an organic compound with special physical and chemical properties. The following is its detailed analysis:
###Physical Properties
1. ** Appearance Properties **: At room temperature and pressure, it is usually a colorless to light yellow liquid, or a low melting point solid. This characteristic is derived from the intermolecular force and structural arrangement.
2. ** Melting Boiling Point **: Because the molecule contains polar group methoxy, and the dideuterium atom affects the intermolecular force, its melting boiling point is different from that of ordinary pyridine derivatives. The specific melting point data needs to be accurately determined experimentally, but it can be speculated that the boiling point is slightly higher than that of pyridine due to the enhanced intermolecular force of methoxy.
3. ** Solubility **: In view of the hydrophilicity of the pyridine ring and the polarity of the methoxy group, the compound has good solubility in polar organic solvents such as methanol, ethanol, and acetone, and also has a certain solubility in water. However, due to the partial hydrophobicity of the molecular carbon chain, the solubility may be limited.
4. ** Density **: The density is closely related to the molecular mass and molecular accumulation. The substitution of the dideuterium atom increases the mass. Under specific conditions, the density may be slightly higher than that of the corresponding undeuterated compound. The exact value needs to be determined experimentally.
###Chemical properties < ** Basic **: The pyridine ring nitrogen atom has a lone pair of electrons and is alkaline. Although the substitution of dideuterium atoms and the presence of methoxy groups have an effect on the density of the cyclic electron cloud, the whole is still alkaline and can react with acids to form salts. It can be used as a base catalyst in organic synthesis or participate in acid-base equilibrium reactions.
2. ** Nucleophilic Substitution Reaction **: The methoxy group is an ortho-para-position group, which increases the density of the pyridine ring ortho-para-position electron cloud and is more susceptible to attack by nucleophilic reagents. Under appropriate conditions, nucleophilic substitution reactions can occur. Nucleophilic reagents such as halogenated hydrocarbons and alcohols can replace atoms or groups at specific positions on the pyridine ring.
3. ** Redox reaction **: The pyridine ring can participate in the redox reaction. Under the action of specific oxidants, the pyridine ring can be oxidized to form products such as pyridine-N-oxide; in some reduction systems, the pyridine ring can be reduced, and the degree of hydrogenation varies depending on the reaction conditions and the reducing agent used.
4. ** Deuterium atomic properties **: Dideuterium substitution makes the C-D bond properties different from the C-H bond, and the C-D bond has a low vibration frequency. In some reactions involving hydrogen atom transfer, the deuterium atom is reactive or different from the hydrogen atom. This can be used to achieve kinetic isotope effects and study the reaction mechanism.

When storing and transporting 2% 2C3-dideuterium-5- (methoxy) pyridine, there are a number of key things to keep in mind.
First, when storing, find a cool, dry and well-ventilated place. This compound is quite sensitive to humidity and temperature, and high temperature or high humidity environment can easily cause its properties to change and even deteriorate. Therefore, every effort should be made to avoid direct sunlight and humid places, and the storage temperature should be maintained within a specific range to prevent its chemical structure from being changed by temperature.
Second, during transportation, be sure to ensure that the packaging is tight and stable. Due to the particularity of the substance, if the package is damaged, it is easy to react with the external environment, which will not only damage its own quality, but also cause harm to the transportation environment. The packaging materials used must be able to effectively resist vibration, collision and external factors to ensure the safety of the transportation process.
Furthermore, whether it is storage or transportation, it is necessary to strictly follow relevant regulations and safety standards. Operators should be professionally trained to be familiar with the characteristics and safe operation procedures of the compound. Storage sites and transportation vehicles must be equipped with corresponding emergency treatment equipment and protective equipment to prevent rapid response in case of unexpected situations and reduce losses and hazards.
In addition, if this compound is mixed with other substances, it may cause adverse reactions. Therefore, contact with incompatible substances should be avoided during storage and transportation, and isolation measures should be taken. Only by paying full attention to the above points can we ensure that 2% 2C3 -dideuterium-5- (methoxy) pyridine remains stable during storage and transportation, ensuring the safety of personnel and the environment.

2% 2C3 -difluoro-5- (methoxy) pyridine, this product is in the market, and its price varies with quality and quantity. The quality is high, and the price is high if the quantity is small. If you buy it in bulk, the average price may be slightly reduced. Looking at the state of various cities, it is widely used, and it is an essential material in medicine and agrochemical industries.
In the field of medicine, based on this, it can be used to make special drugs and treat various diseases. The demand is constant. In the field of agrochemistry, it can be seen that it is used to develop new agents, protect crops, and increase their production.
Due to the ardent market demand, the industry is competing to control it, but its craftsmanship is difficult, and high-quality production is not easy to obtain. And the price of raw materials and the regulations of the government all disturb the market. If the price of raw materials rises, the cost of production will increase, and the price will also rise; the stricter the regulations, the higher the cost of production, and the order of the market can be guaranteed.
In today's market, competition is becoming more and more intense. The new ones want to enter, and the old ones want to expand. Looking ahead, if the technology advances, the quantity of production will increase, the cost will decrease, and the price may be adjusted. And with the progress of medicine and agrochemical industries, their needs may continue to rise, and the market prospect is still considerable.