2 3 Dichloro 4 Trifluoromethyl Pyridine
pyridine pyrrole pyrazine piperidine piperazine

2,3-Dichloro-4-(trifluoromethyl)pyridine

    Specifications

    HS Code

    614563

    Chemical Formula C6H2Cl2F3N
    Molecular Weight 216.0
    Appearance A colorless to pale yellow liquid
    Boiling Point Approximately 192 - 194 °C
    Density Data may vary, around 1.5 - 1.6 g/cm³
    Solubility In Water Low solubility in water
    Solubility In Organic Solvents Soluble in many organic solvents like dichloromethane, toluene
    Vapor Pressure Relatively low vapor pressure

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    General Information
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    Frequently Asked Questions

    As a leading 2,3-Dichloro-4-(trifluoromethyl)pyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2,3-dichloro-4- (trifluoromethyl) pyridine?
    2% 2C3 -difluoro-4- (triethylmethyl) pyridine, which has important uses in many fields.
    In the field of medicinal chemistry, it can be used as a key intermediate. Through specific chemical reactions, it can be constructed into complex drug molecular structures. For example, in the development of some new antibacterial drugs, this is the starting material. By modifying the pyridine ring and side chain, drugs with unique antibacterial activity and specific pathogens can be obtained, providing a new way to deal with the problem of drug-resistant bacterial infections.
    In the field of materials science, it plays a unique role. It can be used to prepare organic optoelectronic materials, which endow materials with specific electrical and optical properties due to their structural properties. For example, it is used in the manufacture of organic Light Emitting Diodes (OLEDs), which can optimize the luminous efficiency, stability and color purity of the device, so that the display screen presents better visual effects and improves the display technology level.
    In the field of pesticide chemistry, it also has outstanding performance. It can be used as a key building block for the synthesis of new pesticide active ingredients. After structural modification and optimization, the synthetic pesticides have high selectivity to pests, high insecticidal activity, and are environmentally friendly, helping to develop green and efficient pesticides, reducing the negative impact of chemical pesticides on the ecological environment, and ensuring sustainable agricultural development.
    In summary, 2% 2C3-difluoro-4- (triethyl) pyridine, with its special structure, has shown broad application prospects in the fields of medicine, materials, pesticides, etc., and has made important contributions to promoting technological progress and innovation in various fields.
    What are the synthesis methods of 2,3-dichloro-4- (trifluoromethyl) pyridine?
    There are several methods for the synthesis of 2% 2C3 -dideuterium-4- (triethoxy) pyridine as follows:
    First, pyridine is used as the starting material. First, a specific halogenation reaction is carried out on the pyridine, and halogen atoms are introduced at the appropriate position of the pyridine ring. This step requires careful regulation of the reaction conditions, such as temperature, reaction time, and the type of halogenated reagent used, to ensure that the halogen atoms are precisely introduced into the desired position. Then, in a strong base environment, the halogenated pyridine is subjected to a nucleophilic substitution reaction with the triethoxy compound. The reaction requires both the strength of the base and the polarity of the reaction solvent. It needs to be carefully screened so that the nucleophile can smoothly attack the halogen check point on the halogenated pyridine and achieve the introduction of triethoxy groups. Finally, through specific deuterated reaction conditions, the substitution of deuterium atoms is achieved at the 2,3-position. This process is extremely critical to the control of the activity, reaction temperature and time of the deuterated reagent to obtain the target product 2% 2C3 -dideuterium-4- (triethoxy) pyridine.
    Second, starting from the pyridine derivative containing a specific substituent. First, the substituent of the derivative is properly modified to convert it into an active group that is easy to react with triethoxy compounds. This modification step needs to be based on the characteristics of the substituents, and the reaction reagents and conditions should be selected reasonably. Next, the modified derivatives are condensed with triethoxy compounds to form pyridine intermediates with triethoxy structures. At this stage, the selectivity and yield of the reaction need to be paid attention to. Subsequently, deuterated reagents are used to carry out deuterated reactions at the 2,3-position of the pyridine ring. Through precise control of the reaction conditions, including but not limited to reagent concentration, reaction temperature and time, the goal of dideuteration is achieved, and 2% 2C3-dideuterium-4- (triethoxy) pyridine is successfully synthesized.
    Third, a metal-catalyzed synthesis strategy is used. The coupling reaction between pyridine derivatives and triethoxy compounds is catalyzed by suitable metal catalysts, such as palladium, nickel and other metal complexes. During this process, factors such as the activity of the metal catalyst, the structure of the ligand, and the base and solvent in the reaction system all have a significant impact on the process and results of the reaction. After the successful introduction of triethoxy groups, deuterium atoms are introduced at the 2,3-position of the pyridine ring by deuteration technology. This deuteration step needs to be optimized for the metal catalytic system to avoid damage to the previously formed structure, so as to efficiently obtain the target product 2% 2C3-dideuterium-4- (triethoxy) pyridine.
    What are the market prospects for 2,3-dichloro-4- (trifluoromethyl) pyridine?
    2% 2C3-difluoro-4- (triethoxymethyl) pyridine, this product has a promising market prospect in the current market. Looking at its characteristics, in the field of pharmaceutical research and development, it can be used as a key intermediate, and many new drugs with high pharmacological activity can be derived through exquisite chemical synthesis paths. Today, the pharmaceutical industry is hungry for innovative drugs, and the research and development process is racing against time, so the demand for such intermediates is on the rise.
    In the field of materials science, this compound may contribute to the creation of new functional materials. With the rapid development of science and technology, the demand for materials with unique properties and novel structures is increasingly strong in the fields of electronics, optics and other materials. The molecular structure of 2% 2C3 -difluoro-4- (triethoxymethyl) pyridine may endow the material with different physical and chemical properties, such as excellent electrical conductivity and optical activity, and then find a place in electronic devices, optical films and other application scenarios.
    From the perspective of agricultural chemistry, the substance may be modified and transformed into a key ingredient of pesticides. Today, green, high-efficiency, and low-toxicity pesticides are the general trend of the industry. Their unique chemical structure may give birth to compounds with high-efficiency insecticidal, bactericidal or herbicidal activities to meet the demand for high-quality pesticides in agricultural production.
    Furthermore, with the deepening of the transformation of the global chemical industry's fine chemical direction, the fine chemical market continues to expand. As an important member of fine chemical products, 2% 2C3-difluoro-4- (triethoxy methyl) pyridine is expected to further expand its market share with the improvement of synthesis process and the reduction of production cost, and the prospect is quite bright.
    What are the physical and chemical properties of 2,3-dichloro-4- (trifluoromethyl) pyridine?
    2% 2C3 -dideuterium-4- (triethylmethyl) pyridine, this is an organic compound. Its physical and chemical properties are quite important, and it is related to the application of this compound in many fields.
    In terms of physical properties, under normal temperature and pressure, this compound may be in a liquid state. Its boiling point, melting point and other properties have a great influence on its storage and use conditions. Generally speaking, the boiling point of an organic compound depends on the strength of the intermolecular forces. The molecular structure of this compound causes the intermolecular forces to have a specific range, which determines its boiling point. If there are strong forces such as hydrogen bonds between molecules, the boiling point may be relatively high; conversely, if there is only a weak van der Waals force, the boiling point is relatively low.
    The melting point is also closely related to the arrangement of molecules. Molecules with regular arrangement have higher lattice energy and higher melting point; disordered arrangement has lower melting point. The molecular structure of 2% 2C3 -dideuterium-4- (triethylmethyl) pyridine may affect its arrangement, which in turn determines the melting point.
    As for solubility, this compound may have some solubility in organic solvents. According to the principle of similarity compatibility, it has better compatibility with organic solvents with similar structures. For example, the interaction with polar organic solvents depends on the polarity of the molecule. If the molecule has a certain polarity, it has good solubility in polar solvents; if it is a non-polar molecule, it is easily soluble in non-polar solvents.
    In terms of chemical properties, the pyridine ring of this compound has a certain alkalinity. The nitrogen atom on the pyridine ring can accept protons and react with acids to form corresponding salts. This basic property can be used to adjust the pH of the reaction system in organic synthesis, or as a base catalyst to participate in some reactions.
    In addition, its substituents, such as 2% 2C3-dideuterium and 4- (triethyl methyl), have a significant impact on the chemical properties. The introduction of deuterium atoms may change the reaction rate due to isotopic effects. The steric resistance of triethyl methyl is large, which can affect the reactivity and selectivity of molecules. In nucleophilic substitution or electrophilic substitution reactions, steric hindrance can prevent reagents from approaching the reaction check point, thereby changing the reaction path and product distribution.
    In summary, the physicochemical properties of 2% 2C3 -dideuterium-4- (triethylmethyl) pyridine are rich and diverse, which is of great significance for its application in organic synthesis, materials science and other fields.
    What are the precautions for storing and transporting 2,3-dichloro-4- (trifluoromethyl) pyridine?
    2% 2C3 -dideuterium-4- (triethylmethyl) pyridine in storage and transportation, be sure to pay attention to the following things:
    First, this material is chemically active, and should be stored in a low temperature, dry and well ventilated place. Due to high temperature and humidity, or cause its chemical reaction, damage the quality. It is necessary to keep away from fire and heat sources to prevent the risk of fire and explosion. To cover its chemical properties or make it burn or even explode in case of open flame or hot topic.
    Second, storage containers are also very critical. Containers with good corrosion resistance and sealing must be used. Because the substance or react with certain materials, the container is damaged and leaks. Choosing a container of suitable material can ensure the stability of the substance and avoid its interaction with the external environment.
    Third, during transportation, ensure that the container is stable and free from vibration and collision. Violent vibration or collision, or damage to the container, causing material leakage. And the transportation vehicle should be equipped with corresponding fire and leakage emergency treatment equipment for emergencies.
    Fourth, people who operate and come into contact with this object need to wear appropriate protective equipment. Such as protective gloves, goggles, protective clothing, etc., to avoid contact with the skin and eyes. If you accidentally come into contact, you should immediately rinse with a lot of water and seek medical attention in time. Because of it or cause irritation and damage to the human body.
    Fifth, regardless of storage or transportation, relevant regulations and safety standards must be strictly followed. Make detailed records, including quantity, warehousing time, transportation route, etc., for traceability and management. In this way, the safety and stability of 2% 2C3 -dideuterium-4- (triethylmethyl) pyridine during storage and transportation can be guaranteed.