2 3 Dibromo 5 Nitro Pyridine
pyridine pyrrole pyrazine piperidine piperazine

2,3-DIBROMO-5-NITRO PYRIDINE

    Specifications

    HS Code

    718026

    Chemical Formula C5H2Br2N2O2
    Molar Mass 295.89 g/mol
    Appearance Solid (usually white or off - white powder)
    Physical State At Room Temp Solid
    Melting Point 158 - 162 °C
    Boiling Point N/A (decomposes before boiling)
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in some organic solvents like dichloromethane, chloroform
    Density N/A (no common value found)
    Stability Stable under normal conditions, but sensitive to light and heat
    Pka N/A (no common value found)
    Odor Odorless or faint odor

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    General Information
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    Frequently Asked Questions

    As a leading 2,3-DIBROMO-5-NITRO PYRIDINE supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 2,3-dibromo-5-nitropyridine?
    2% 2C3-dibromo-5-fluoropyridine, this substance is a white to light yellow solid, and its melting boiling point has its specific value. Its melting point is about [X] ° C under common conditions. This melting point characteristic causes it to undergo a phase transition under a specific temperature environment, from solid to liquid. The boiling point is about [Y] ° C, and when it reaches this temperature, it will transform from liquid to gaseous.
    From the perspective of chemical stability, it is relatively stable in normal mild environments, and it is not easy to react rapidly with some common chemicals such as oxygen and nitrogen in the air. However, if placed in a more extreme environment, such as a strong acidic or alkaline medium, the bromine and fluorine atoms in its structure may participate in the reaction, resulting in a change in molecular structure.
    In terms of solubility, it has a certain solubility in common organic solvents such as dichloromethane and chloroform, and can be better dispersed in these solvent systems to form a homogeneous solution. This property provides convenience for related chemical synthesis operations. In organic synthesis experiments, these solvents can be used to dissolve it, and then various chemical reactions can be carried out. However, in water, its solubility is poor, mainly due to the lack of groups in its molecular structure that effectively interact with water molecules, such as water-soluble hydroxyl groups, carboxyl groups, etc., so it is mostly in solid form in the aqueous phase, making it difficult to disperse uniformly.
    What are the chemical properties of 2,3-dibromo-5-nitropyridine?
    2% 2C3-dibromo-5-fluoropyridine is an organic compound with unique chemical properties and extraordinary effects in the field of organic synthesis.
    This compound has the structural characteristics of halopyridine, and fluorine and bromine atoms endow it with active reactivity. Bromine atoms can participate in nucleophilic substitution reactions. Under appropriate conditions, they can be replaced by a variety of nucleophilic reagents, such as alcohols and amines, to construct various nitrogen-containing and oxygen-containing derivatives. It is often used in pharmaceutical chemistry to introduce specific functional groups to optimize drug activity and properties.
    Fluorine atoms have high electronegativity, which can enhance molecular polarity and change the physical and chemical properties of compounds. Fluorinated organic compounds often have special biological activities in the fields of medicine and pesticides. 2% 2C3-dibromo-5-fluoropyridine or fluorine atoms exist, showing unique biological activities and pharmacological properties, and have attracted much attention in the development of new drugs.
    In addition, its pyridine ring is aromatic and basic, and can interact with protons or metal ions to form pyridine salts or metal complexes. These properties have potential applications in the fields of materials science and catalysis, such as the preparation of functional materials or as ligands to participate in catalytic reactions.
    However, due to the presence of halogen atoms, the compound has certain toxicity and environmental effects. In the production, use and treatment, it is necessary to follow safety regulations and environmental protection requirements to reduce its harm to human body and the environment.
    In short, 2% 2C3-dibromo-5-fluoropyridine has broad application prospects in many fields such as organic synthesis, medicine, pesticides and materials science due to its unique chemical properties, but its potential hazards need to be treated with caution.
    What are the common synthesis methods of 2,3-dibromo-5-nitropyridine?
    2% 2C3-dibromo-5-fluoropyridine is an important intermediate in the field of organic synthesis, which is widely used in many fields such as medicinal chemistry and materials science. Its common synthesis methods are mainly as follows:
    1. ** Halogenation reaction **: using appropriate pyridine derivatives as starting materials, bromine atoms and fluorine atoms are introduced by halogenation reaction. For example, pyridine and bromine can be reacted under specific reaction conditions to form bromine-containing pyridine intermediates, and then fluorine atoms can be introduced through fluorination reaction. In this process, the reaction solvent, catalyst and reaction temperature should be carefully selected to ensure the selectivity and yield of the reaction. For example, in some reactions, acetic acid is used as a solvent, and under the action of a specific catalyst, pyridine reacts with bromine at a suitable temperature, which can effectively generate bromopyridine. Then, with a suitable fluorinated reagent, such as potassium fluoride, the fluoride reaction is completed with the help of a phase transfer catalyst.
    2. ** Metal Catalytic Coupling Reaction **: The coupling between different halogens and pyridine derivatives is achieved with the help of a metal catalyst. Coupling reactions like palladium catalysis are commonly used. Select suitable halogenated aromatics or halogenated alkanes, and couple with pyridine derivatives containing specific functional groups under the combined action of palladium catalysts, ligands and bases to form a carbon-carbon or carbon-heteroatom bond of the target product. For example, using palladium (0) complexes as catalysts and bipyridine compounds as ligands, in the presence of bases such as potassium carbonate, halopyridine and halogenated bromide are coupled to react, and 2% 2C3-dibromo-5-fluoropyridine can be successfully synthesized.
    3. ** Multi-step synthesis strategy **: In view of the complexity of the structure of the target compound, a multi-step synthesis strategy is sometimes required. Starting from a simple pyridine starting material, the target molecular structure is gradually built through multi-step functional group transformation, protection and deprotection operations. For example, the specific position on the pyridine ring is functionalized first, and then some functional groups are protected according to the reaction requirements. After completing the key reaction, the protective group is finally removed to obtain the product. Although this method is cumbersome, it can precisely control the product structure and improve the synthesis success rate.
    What are the main uses of 2,3-dibromo-5-nitropyridine?
    2% 2C3-dibromo-5-fluoropyridine is a key intermediate in organic synthesis and is widely used in the fields of medicine, pesticides, etc.
    In the field of medicine, it can be used as a starting material for many drug synthesis. The structure of the Gainpyridine ring is common in many bioactive molecules, and the introduction of fluorine and bromine atoms can adjust the physical, chemical properties and biological activities of the molecule. For example, by subsequent chemical reactions on it, drug molecules with high affinity to specific targets can be constructed, which can be used for the treatment of diseases. For example, in the development process of some anti-cancer drugs, 2% 2C3-dibromo-5-fluoropyridine will be used as the basic raw material to optimize the targeting and inhibitory effect of the drug on cancer cells by modifying the substituents on the pyridine ring.
    In the field of pesticides, 2% 2C3-dibromo-5-fluoropyridine is also an important synthetic building block. The design of pesticides needs to take into account the activity of pests and pathogens, as well as the safety of the environment and non-target organisms. The special structure of this compound can be chemically converted to prepare pesticide products with high insecticidal and bactericidal activities. For example, some new insecticides, starting with 2% 2C3-dibromo-5-fluoropyridine, synthesized through multi-step reactions, exhibit excellent killing ability against specific pests, and have low residues and are environmentally friendly.
    In addition, because its structure contains active halogen atoms, it is also an important intermediate for building complex organic molecules in organic synthesis chemistry. Chemists can use the different reactivity of bromine atoms and fluorine atoms to introduce various functional groups through nucleophilic substitution, coupling and other reactions to expand the structural diversity of molecules, providing a foundation for the creation of new functional materials and fine chemicals.
    What are the precautions for storing and transporting 2,3-dibromo-5-nitropyridine?
    2% 2C3-dibromo-5-fluoropyridine requires attention to many key matters during storage and transportation.
    When storing, the first environmental conditions should be selected. A dry, cool and well-ventilated place should be selected, because the substance may be sensitive to humidity and temperature. Humid environment may cause moisture and deterioration, high temperature may cause chemical reactions, and even cause safety hazards. Therefore, the warehouse temperature should be strictly controlled within a specific range, and the humidity should also be maintained in an appropriate range.
    Furthermore, attention should be paid to isolation from other substances. 2% 2C3-dibromo-5-fluoropyridine has unique chemical properties or may react dangerously with certain chemicals. Such as strong oxidants, strong acids, strong alkalis, etc., should be stored separately from them, and must not be mixed to prevent accidents.
    The choice of storage container is also crucial. Containers with good corrosion resistance and sealing are required. This can not only avoid material leakage, but also prevent external factors from affecting it. At the same time, containers must be clearly marked with key information such as substance names, properties, and hazard warnings for identification and management.
    During transportation, safety and security are of paramount importance. Transportation vehicles need to be equipped with professional protective equipment and emergency treatment tools for emergencies. Transportation personnel should also be professionally trained and familiar with the characteristics of the substance and emergency response methods.
    In addition, ensure that the packaging is intact during transportation to avoid bumps and vibrations that cause the container to break. Strictly follow the established transportation route, away from densely populated areas and important facilities, to reduce latent risks.
    In short, whether it is storing or transporting 2% 2C3-dibromo-5-fluoropyridine, it is necessary to strictly follow the relevant norms and requirements, put safety first, and ensure the safety of people and the environment in all aspects.