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What are the main uses of 2,3-dibromo-4- (trifluoromethyl) pyridine?
2% 2C3-dibromo-4- (triethylmethyl) pyridine has a wide range of main uses. In the field of medicine, it is often a key intermediate for the synthesis of many specific drugs. This intermediate can be integrated into the molecular structure of the drug through a specific reaction path, giving the drug unique pharmacological activity and helping to develop new drugs for specific diseases. For example, the creation of some antibacterial and antiviral drugs may rely on this.
In the field of materials science, it may be able to participate in the construction of functional materials. With its own chemical structure properties, it can adjust the electrical, optical and other physical properties of the material. For example, in the preparation of organic optoelectronic materials, the introduction of such compounds is expected to optimize the charge transfer efficiency and luminescence properties of the materials, and contribute to the development of new optoelectronic devices, such as organic Light Emitting Diodes (OLEDs) and solar cells.
In the fine chemical industry, it is also an important raw material for the synthesis of high-value-added fine chemicals. After a series of chemical reactions, additives and other additives with special functions can be derived. For example, adding additives synthesized from it to some high-end coatings can significantly improve the adhesion, weather resistance and other qualities of the coatings, meeting different industrial and civilian needs. Therefore, 2% 2C3-dibromo-4- (triethylmethyl) pyridine plays an indispensable role in many fields such as medicine, materials and fine chemicals, and is of great significance to promoting technological innovation and product upgrading in related industries.
What are the synthesis methods of 2,3-dibromo-4- (trifluoromethyl) pyridine?
To prepare 2,3-dibromo-4- (triethyl) pentane, the method is as follows:
First take an appropriate amount of 4- (triethyl) pentane-1-ene as the starting material. This alkene compound has active carbon-carbon double bonds and can be added to bromine. In a suitable reaction vessel, put 4- (triethyl) pentane-1-ene, keep the reaction system at a low temperature and protected from light, and slowly add liquid bromine dropwise. When liquid bromine is added dropwise, the π bond of the carbon-carbon double bond breaks, and bromine atoms are added to the carbon atoms at both ends of the double bond, which is the electrophilic addition reaction process.
The reaction mechanism is as follows: the liquid bromine molecule is polarized by the electron cloud of alkene bonds, and one end is partially positively charged, attacking the double bond to form the bromide ion intermediate, and then the bromide negative ion attacks the bromide ion from the reverse side to generate 2,3-dibromo-4- (triethylmethyl) pentane.
When operating, pay close attention to the reaction temperature to prevent the reaction from being too violent. Due to the strong corrosive and volatile nature of liquid bromine, the operation should be carried out in a well-ventilated fume hood, and protective measures should be taken. At the same time, after the reaction is completed, the product needs to be separated and purified, and distillation, extraction and other means can be used to obtain pure 2,3-dibromo-4- (triethyl) pentane.
In addition, 4- (triethyl) pentene-2-ene can also be used as raw material. When this ene is added to bromine, it also follows the electrophilic addition mechanism. Due to the different double bond positions, although the target product 2,3-dibromo-4- (triethyl) pentane can also be obtained, the reaction activity and product ratio may be slightly different from that of 4- (triethyl) pentene as raw material. During the operation, attention should also be paid to controlling the reaction conditions and safety protection, and finally the target product can be obtained through appropriate separation and purification steps.
What are the physical properties of 2,3-dibromo-4- (trifluoromethyl) pyridine?
2% 2C3-dibromo-4- (triethylmethyl) pyridine is an organic compound. It has the following physical properties:
Viewed at room temperature, it is usually solid, white or nearly white in color. When pure, the appearance is fine and uniform, and there is no obvious impurity variegation. The crystal form of this compound is affected by synthesis conditions and molecular arrangement, and it is either needle-like crystals or flake crystals.
Smell, it has a special smell, although it is not pungent and malodorous, but it is quite recognizable. This smell is derived from the interaction of bromine atoms and pyridine cyclic groups in its molecular structure. < Br > Measure its melting point. Due to the specific intermolecular forces, it has a fixed melting point. At a suitable heating rate, when it reaches a certain temperature, the crystalline state turns into a liquid state. This melting point value is an important physical constant for identifying the compound.
Looking at its solubility, it has a certain solubility in organic solvents, such as common ethanol, ether, chloroform, etc. Due to the principle of similar miscibility, its organic structure and organic solvent molecules can form a certain force to help it dissolve; in water, due to the large difference in polarity, the solubility is very small.
In terms of its density, it is larger than that of water. If it is placed in a container with water, it will sink to the bottom. Due to the relative mass and close arrangement of molecules, the mass per unit volume is larger.
In addition, the compound is also characterized by photothermal stability. Under light or high temperature, certain chemical bonds in the molecular structure may be affected, causing decomposition or chemical reactions. Therefore, it is necessary to store it in a cool place away from light to ensure its chemical stability.
What are the chemical properties of 2,3-dibromo-4- (trifluoromethyl) pyridine?
2% 2C3-dibromo-4- (triethylmethyl) pyridine, an organic compound. It has the following chemical properties:
1. ** Nucleophilic Substitution Reaction **: In this compound, the bromine atom is highly active and can be used as a leaving group. When encountering nucleophilic reagents, nucleophilic reagents will attack the carbon atoms attached to bromine and replace the bromine atoms to form new compounds. For example, with sodium alcohol as a nucleophilic reagent, the alkoxy group will replace the bromine atom to form ether products. This reaction is often used in organic synthesis to form carbon-heteroatomic bonds.
2. ** Redox Reaction **: The pyridine ring has a certain electron cloud density and can participate in the redox reaction. Under the action of suitable oxidants, the pyridine ring or the side chain part can be oxidized to form products such as pyridine-N-oxide; and under the action of reducing agents, the pyridine ring may also undergo hydroreduction, reducing the degree of unsaturation of the pyridine ring and forming partially or fully hydrogenated pyridine derivatives.
3. ** Basic **: The nitrogen atom on the pyridine ring has a pair of electrons, giving the compound a certain alkalinity. Under acidic conditions, the nitrogen atom can accept protons and form pyridine salts. This property can be used to adjust the solubility and reactivity of compounds, and can also be used as a base catalyst in some reactions to promote the reaction.
4. ** Halogenation Reaction **: In addition to the bromine atoms it carries, halogenation reactions may also occur at other positions on the pyridine ring under specific conditions. For example, under suitable catalyst and reaction conditions, more halogen atoms can be introduced, thereby further changing the properties and reactivity of compounds, providing more possibilities for subsequent organic synthesis.
What is the price range of 2,3-dibromo-4- (trifluoromethyl) pyridine in the market?
2% 2C3-dibromo-4- (triethylmethyl) pyridine, the price range of this product in the market varies depending on various factors such as category, purity, supply and demand.
If it is of ordinary purity, it is used for general chemical experiments or industrial basic synthesis, and its price is about a few to ten yuan per gram. If the purity is about 95%, the price per gram may be between five and twenty yuan.
If the purity requirements are strict, up to 98% and above, it is mostly used in high-end pharmaceutical research and development, fine chemical industry and other fields, and its price rises sharply. For such high purity, the price per gram may reach more than 50 yuan, or even more than 100 yuan.
In addition, market supply and demand also affect its price. If there are many people who want it, and there are few products, the price may rise; conversely, if the supply exceeds the demand, the price may fall. And it fluctuates in different seasons due to changes in raw material acquisition and production scale.
To get an accurate price, you can consult chemical raw material suppliers and chemical trading platforms, and compare the quotations of various companies to get the current price range.