2,3,6-Trifluoropyridine

2%2C3%2C6-%E4%B8%89%E6%B0%9F%E5%90%A1%E5%95%B6, that is, 2,3,6-trifluoropyridine. This substance has no relevant records in the era covered by Tiangong Kaiwu. However, in terms of today's chemical knowledge, its main uses are quite wide.
In the field of pharmaceutical synthesis, 2,3,6-trifluoropyridine is a key intermediate. In today's pharmaceutical research and development, the creation of many new drugs depends on its participation. For example, in the synthesis of some compounds with specific biological activities, 2,3,6-trifluoropyridine can introduce unique fluorine atomic groups through ingenious chemical transformation. Fluorine atoms have the characteristics of high electronegativity and small atomic radius, which can significantly change the physical and chemical properties and biological activities of compounds. In this way, the absorption, distribution, metabolism and excretion process of drugs can be optimized, and the efficacy of drugs can be improved and toxic side effects can be reduced.
In the field of pesticides, 2,3,6-trifluoropyridine is also important. The preparation of many high-efficiency, low-toxicity and environmentally friendly pesticides requires this as a raw material. Because it can endow pesticide molecules with specific chemical structures and activities, enhance the inhibition and killing ability of pesticides to pests and pathogens, and reduce the harm to non-target organisms and the environment, it meets the current needs of green agriculture development.
In the field of materials science, 2,3,6-trifluoropyridine is also useful. In the synthesis of new functional materials, it can be used as a structural unit to construct polymer materials with special properties. For example, the synthesis of materials with excellent thermal stability, chemical stability or optical properties is widely used in cutting-edge fields such as electronics and optics.

2%2C3%2C6-%E4%B8%89%E6%B0%9F%E5%90%A1%E5%95%B6, that is, 2,3,6-trifluoropyridine, is an organic compound. Its physical properties are quite characteristic:
- ** Appearance properties **: At room temperature, 2,3,6-trifluoropyridine is often colorless to light yellow liquid state, clear and transparent, and pure in appearance.
- ** Odor **: This substance emits a special smell, but the specific smell is difficult to describe accurately, and it needs to be perceived in person to understand.
- ** Melting point and boiling point **: The melting point is about -39 ° C, and the boiling point is roughly between 113-114 ° C. This boiling point characteristic makes it flexible to change between liquid and gas states under specific temperature environments. < Br > - ** Solubility **: In organic solvents, such as common ethanol, ether, etc., 2,3,6-trifluoropyridine exhibits good solubility and can be mutually soluble with it to form a uniform and stable mixed system; however, in water, its solubility is poor, and the two are difficult to blend.
- ** Density **: The density is about 1.33 g/mL, which is slightly larger than water, which determines that when mixed with water, it will settle at the bottom.
The above physical properties are all inherent properties of 2,3,6-trifluoropyridine. These properties play a key role in many fields such as organic synthesis and pharmaceutical research and development, laying the foundation for related research and applications.

The chemical properties of 2% 2C3% 2C6-tribromopyridine are still stable. In this compound, the characteristics of bromine atom interact with the structure of the pyridine ring to create its chemical behavior.
Bromine atom has high electronegativity, and can produce induction and conjugation effects on the pyridine ring. The induction effect makes the electron cloud biased towards the bromine atom, and the conjugation effect affects the electron cloud distribution of the pyridine ring. The synergy between the two makes the reactivity of this compound unique.
Under common organic reaction conditions, 2% 2C3% 2C6-tribromopyridine is not easy to spontaneously decompose or react violently. The aromaticity of the pyridine ring gives it a certain stability, making it resistant to the attack of some mild reagents.
When encountering strong oxidants or specific nucleophiles, its structure will also change. Strong oxidants can oxidize bromine atoms or change the electron cloud structure of the pyridine ring, which can lead to further reactions. Nucleophiles can attack the check point of low electron cloud density on the pyridine ring and break the original chemical equilibrium.
Overall, 2% 2C3% 2C6 -tribromopyridine is relatively stable in conventional environments and general chemical operations. However, under extreme or specific chemical conditions, its structure and properties will undergo significant changes, which are determined by its own chemical structure.

2%2C3%2C6-%E4%B8%89%E6%B0%9F%E5%90%A1%E5%95%B6%E7%9A%84%E5%90%88%E6%88%90%E6%96%B9%E6%B3%95%E6%9C%89%E4%B8%8B%E5%88%97%E5%87%A0%E7%A7%8D%EF%BC%9A
###1. Using 2-bromopropane as a raw material
First, 2-bromopropane is heated in a potassium hydroxide alcohol solution to undergo a digestion reaction, resulting in propylene:
$CH_3CHBrCH_3 + KOH\ xrightarrow [\ Delta] {alcohol} CH_2 = CHCH_3 + KBr + H_2O $
Then, propylene and hydrogen bromide undergo an anti-Martensitic addition reaction in the presence of peroxide to generate 1-bromopropane:
$CH_2 = CHCH_3 + HBr\ xrightarrow [] {peroxide} CH_3CH_2CH_2Br $
1-bromopropane reacts with magnesium in anhydrous ether to form Grignard reagents:
$CH_3CH_2CH_2Br + Mg \ Xrightarrow [] {Anhydrous ether} CH_3CH_2CH_2MgBr $
Grignard reagent reacts with ethylene oxide, and then acid hydrolyzes to obtain 1-pentanol:
$CH_3CH_2CH_2MgBr +\ overset {O} {\ overset {| |} {CH_2 - CH_2}}\ xrightarrow [] {Anhydrous ether} CH_3CH_2CH_2CH_2CH_2OMgBr $
$CH_3CH_2CH_2CH_2CH_2OMgBr + H_2O\ xrightarrow [] {H ^ +} CH_3CH_2CH_2CH_2CH_2OH + Mg (OH) Br $
1-pentanol is heated under the action of concentrated sulfuric acid to produce 1-pentene:
$CH_3CH_2CH_2CH_2CH_2OH\ xrightarrow [\ Delta] {concentrated sulfuric acid} CH_3CH_2CH_2CH = CH_2 + H_2O $
1-pentene is added to hydrogen bromide to form 2-bromopentane:
$CH_3CH_2CH_2CH = CH_2 + HBr\ xrightarrow [] {} CH_3CH_2CH_2CHBrCH_3 $
2-bromopentane is heated in potassium hydroxide alcohol solution to form 2-pentene:
$CH_3CH_2CH_2CHBrCH_3 + KOH\ xrightarrow [\ Delta] {alcohol} CH_3CH_2CH = CHCH_3 + KBr + H_2O $
2-pentene is added to bromine in carbon tetrachloride solution to form 2,3-dibromopentane:
$CH_3CH_2CH = CHCH_3 + Br_2\ xrightarrow [] {CCl_4} CH_3CH_2CHBrCHBrCH_3 $
2,3-dibromopentane is eliminated under the action of zinc powder to form 2,3-pentadiene:
$CH_3CH_2CHBrCHBrCH_3 + Zn\ xrightarrow [] {} CH_3CH_2C\ equiv CCH_3 + ZnBr_2 $
2,3-pentadiene and hydrogen bromide undergo 1,4-addition reaction to form 2-bromo-2,3-pentadiene:
$CH_3CH_2C\ equiv CCH_3 + HBr\ xrightarrow [] {} CH_3CH_2C (Br) = C = CH_2 $
< Br > 2-bromo-2,3-pentadiene is added to hydrogen bromide under appropriate conditions to produce 2,3,6-tribromopentane.
###2. Propylene is used as a raw material
Propylene is added to hydrogen bromide to generate 2-bromopentane:
$CH_2 = CHCH_3 + HBr\ xrightarrow [] {} CH_3CHBrCH_3 $
The subsequent steps are similar to the method using 2-bromopentane as a raw material. 2-bromopentane is first converted to 2,3-pentadiene, and then 2,3,6-tribromopentane is prepared by the addition reaction with hydrogen bromide.
###3. Other raw material combinations
can also consider using propanol as raw materials, first converting propanol into propylene or halogenated propane, and then gradually building carbon chains and introducing bromine atoms through a series of reactions, and finally synthesizing 2,3,6-tribromopentane. The specific process involves the elimination of alcohols, the substitution and addition of halogenated hydrocarbons, and the synthesis of the target product can be achieved through rational design of the reaction route. Different raw material choices and reaction routes have their own advantages and disadvantages, and the optimal synthesis method needs to be determined by considering factors such as raw material cost, reaction conditions, and yield.

In today's world, the market is unpredictable, and the price of 2,3,6-trifluoropyridine is difficult to determine. However, according to the current market conditions and changes in the past, its price is about within a certain range.
Looking at the supply and demand of the city, if there are many people in need and few people in supply, the price will rise; on the contrary, if the supply exceeds the demand, the price will be reduced. And the difficulty of preparing this substance and the lack of raw materials are also variables in the price.
Or there are clouds, the low price can be hundreds of gold per catty, and the high price can range from thousands of gold. If the preparation method is simple and easy, the labor cost is saved, and the price may decrease; if the process is complicated and the materials used are expensive, the price will increase.
And the competition in the market, the competition of various families, also affects its price. Good operators compete for the market with good prices and good goods, and the price may be stable or decline; if they are exclusive, the price may be whatever they want.
However, everything in the world is not static. The change of the market, in an instant, the rise and fall of the price, it is difficult to predict. Only by understanding the market conditions and moving according to the times, is what merchants want. Therefore, the price of 2,3,6-trifluoropyridine is about hundreds of gold to thousands of gold, but this is only the current estimate, and the price in the future will change according to the times.