2 3 5 Trimethylpyridine
pyridine pyrrole pyrazine piperidine piperazine

2,3,5-Trimethylpyridine

    Specifications

    HS Code

    853764

    Name 2,3,5-Trimethylpyridine
    Molecular Formula C8H11N
    Molar Mass 121.18 g/mol
    Appearance Colorless to light yellow liquid
    Odor Pungent, pyridine - like odor
    Density 0.934 g/cm³ (at 20 °C)
    Boiling Point 171 - 172 °C
    Melting Point -46 °C
    Solubility In Water Slightly soluble
    Flash Point 55 °C
    Refractive Index 1.495 - 1.497 (at 20 °C)

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    Frequently Asked Questions

    As a leading 2,3,5-Trimethylpyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 2,3,5-trimethylpyridine?
    2% 2C3% 2C5 -trimethylpyridine, its physical properties are as follows:
    This substance is mostly a colorless to light yellow liquid at room temperature, with a special odor of pyridine compounds, and has a certain irritation.
    The boiling point is about 171-173 ° C. The boiling point allows it to be separated from the mixture at the corresponding temperature conditions. The melting point is about -45 ° C. This melting point characteristic determines its low temperature state. If the temperature is lower than the melting point, it will solidify into a solid state.
    In terms of density, it is about 0.956-0.963g/cm ³. Compared with water, the density is less than that of water. If mixed with water, it will float on water.
    In terms of solubility, slightly soluble in water, but miscible with organic solvents such as ethanol and ether. In chemical production, it can be separated, purified or used as a solvent to participate in the reaction according to the solubility characteristics.
    In addition, 2,3,5-trimethylpyridine also has certain volatility and will gradually evaporate in the air. Safety measures such as ventilation should be paid attention to during operation to prevent impact on human body and environment. Its physical properties are of great significance in many fields such as chemical industry and pharmaceutical synthesis. It can be used as an intermediate in organic synthesis and lays the foundation for related Product Research & Development and production.
    What are the chemical properties of 2,3,5-trimethylpyridine?
    2% 2C3% 2C5 -trimethylphenyl, its chemical properties are quite unique. This compound has a certain stability, because of the presence of methyl groups, which makes the molecular structure change.
    Looking at its physical properties, under room temperature, it is either liquid or solid, but the specific form depends on the surrounding environmental conditions. Its melting point and boiling point vary with the number and location of methyl groups. The increase of methyl groups often enhances the intermolecular force, causing the melting point and boiling point to rise.
    In terms of chemical activity, due to the conjugated system of benzene rings, it has certain aromaticity and is prone to electrophilic substitution reactions. The electron cloud density on the benzene ring increases due to the electron supply effect of methyl groups, making it easier for electrophilic reagents to attack. For example, in the halogenation reaction, the halogen atom easily replaces the hydrogen atom on the benzene ring.
    Furthermore, its solubility also has characteristics. Since methyl is a hydrophobic group, it has poor solubility in water, but it has good solubility in organic solvents such as ethanol and ether.
    And because its chemical structure contains methyl, it can participate in a variety of organic synthesis reactions. For example, by reacting with some reagents, its structure can be further modified to prepare derivatives with different properties, which are widely used in the field of organic synthesis.
    This is a summary of the chemical properties of 2% 2C3% 2C5 -trimethylphenyl.
    What are the main uses of 2,3,5-trimethylpyridine?
    2% 2C3% 2C5-trimethylpyridine, its main use?
    2,3,5-trimethylpyridine is an important class of organic compounds, which are widely used in the chemical and pharmaceutical fields.
    In the chemical industry, it is often a key intermediate in the synthesis of other fine chemicals. Due to the unique structure and chemical properties of the pyridine ring, 2,3,5-trimethylpyridine can be derived from a variety of chemical reactions. For example, by halogenation, nitrification, oxidation and other reactions, the methyl group or other positions on the pyridine ring are modified, and then compounds with specific structures and functions are synthesized, which are used in the preparation of dyes, fragrances and polymer materials.
    In the field of medicine, 2,3,5-trimethylpyridine also plays an important role. Because of its certain biological activity, it can be used as a lead compound. After structural optimization and modification, drugs with specific pharmacological activities can be developed. In the process of many drug development, compounds containing pyridine structure are used as starting materials, and different substituents are introduced to adjust the activity, selectivity and pharmacokinetic properties of the drug. The special structure of 2,3,5-trimethylpyridine provides a unique chemical framework for pharmaceutical chemists to help develop new drugs to deal with various diseases, such as anti-tumor, anti-infection and other fields.
    In summary, 2,3,5-trimethylpyridine, with its unique chemical structure, plays an indispensable role in the chemical and pharmaceutical industries, promoting technological development and product innovation in related fields.
    What are the preparation methods of 2,3,5-trimethylpyridine?
    2% 2C3% 2C5-trimethylbenzene, there are many ways to prepare it.
    One is the Fu-gram alkylation method. Benzene is used as a raw material, and under the catalysis of Lewis acid such as anhydrous aluminum trichloride, it reacts with halogenated alkanes such as chloromethane, chloroethane, and chloropropane. For example, when benzene and chloromethane are reacted, the benzene ring of benzene is nucleophilic, while the chlorine atom in chloromethane is affected by methyl groups and has a certain positive electricity. Under the action of catalysts, chloromethyl replaces the hydrogen atom on the benzene ring and gradually introduces methyl groups to obtain 2,3,5-trimethylbenzene. However, in this process, the electron cloud density of the benzene ring increases after the introduction of methyl as the power supply group, and further substitution is more likely to occur. Therefore, the reaction conditions need to be carefully regulated to prevent the formation of multiple substitution by-products.
    The second is the isomerization method. Other methyl benzene isomers, such as homotrimethylbenzene, can be prepared first, and then the isomerization reaction occurs under the action of a specific catalyst. The catalysts used are mostly solid acid catalysts, such as zeolite molecular sieve catalysts. These catalysts have unique pore structures and acidic check points, which can selectively catalyze the migration and rearrangement of methyl on the benzene ring, thereby converting other methyl benzene isomers into 2,3,5-trimethylbenzene. The key to this method is to find efficient and highly selective catalysts to improve the yield of the target product.
    The third is to separate and purify coal dry distillation or petroleum reforming products as raw materials. During coal dry distillation, the generated coal tar contains many aromatic hydrocarbons, including various isomers of methyl benzene. By a series of separation methods such as distillation and extraction, 2,3,5-trimethylbenzene can be separated from the complex mixture of coal tar. The petroleum reforming products also contain aromatic hydrocarbons, and the target products can also be obtained through similar separation operations. However, the products obtained by this route are often mixed with impurities and need to be further refined to achieve high purity requirements.
    What are the precautions for storing and transporting 2,3,5-trimethylpyridine?
    2% 2C3% 2C5-trimethylpentane requires careful attention when storing and transporting.
    Safety is the first issue. This is a flammable product. In the storage place, it must be kept away from fire and heat sources. Fireworks are strictly prohibited, and complete fire protection facilities and equipment must be equipped. The storage site must be well ventilated to prevent the accumulation of combustible gases and the risk of explosion. When transporting, the transportation vehicle should also meet fire safety standards and be equipped with corresponding fire protection equipment.
    Furthermore, it is related to the storage environment. It should be stored in a cool, dry and well-ventilated place, away from direct sunlight and humid environment. Due to sun exposure and humidity or chemical changes caused by it, the quality will be affected. Storage containers should also be tightly sealed to prevent leakage, and suitable materials, such as corrosion-resistant metal or special plastic containers, should be selected to prevent corrosion and leakage of the container.
    The transportation process should not be ignored. To ensure that the transportation vehicle runs smoothly, avoid bumps and violent vibrations, to prevent damage to the storage container and cause leakage. Transport personnel should be professionally trained and familiar with the characteristics of the substance and emergency treatment methods. In the event of an accident such as leakage, it can be disposed of quickly and properly to reduce the harm.
    In addition, whether it is storage or transportation, relevant regulations and standards must be strictly followed. Keep detailed records, covering information such as storage volume, warehousing time, transportation route, etc., for supervision and traceability.
    Only during the storage and transportation of 2% 2C3% 2C5-trimethylpentane can the above matters be treated carefully to ensure its safety and stability and avoid accidents.