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What is the main use of 2,2 '-pyridine-2,6-diyldiethanol?
2%2C2%27-pyridine-2%2C6-diyldiethanol, the Chinese name is often 2,2 '- (pyridine-2,6-diyl) diethyl alcohol. This substance has a wide range of uses.
In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of many drugs. Due to its special structure of pyridine ring and alcohol hydroxyl groups, it can participate in various chemical reactions and help build complex drug molecular structures. For example, when developing certain compounds with specific biological activities, 2,2' - (pyridine-2,6-diyl) diethyl alcohol can be used as a starting material. Through a series of reactions, its structure can be gradually converted into molecules that meet drug needs, providing an important cornerstone for drug development.
In the field of materials science, it also has important uses. The pyridine ring and alcohol hydroxyl groups endow the substance with unique chemical and physical properties, which can be used to prepare functional materials. For example, it can be introduced into polymer materials to improve the solubility and stability of the material through its special structure or endow the material with specific response properties, such as responding to specific environmental factors, so as to expand the application of the material in different fields, such as the field of smart materials.
In organic synthesis chemistry, it is a class of commonly used organic synthesis reagents. Because it contains active hydroxyl groups and pyridine rings with coordination ability, it can participate in many organic reactions such as esterification, etherification, and nucleophilic substitution. In the design of organic synthesis routes, it provides various possibilities for constructing complex organic molecular structures, and helps chemists synthesize organic compounds with unique structures and functions.
What are the physical properties of 2,2 '-pyridine-2,6-diyldiethanol
2% 2C2% 27 - pyridine - 2% 2C6 - diyldiethanol is an organic compound. Its physical properties are quite unique, with the following characteristics.
Looking at its shape, under normal circumstances, it is mostly colorless to light yellow viscous liquid, just like warm grease, and it is smooth when flowing. This compound is stable at room temperature and pressure. In case of hot topics or open flames, it is at risk of ignition and explosion. It must be properly disposed of to ensure safety.
Its melting point is low, about [specific value] ℃. If the ambient temperature rises slightly, it is easy to solidify into a liquid state. The boiling point is higher, reaching [specific value] ° C. To make it boil and vaporize, more energy needs to be applied. This property makes it able to maintain a liquid state in high temperature environments, and is widely used.
Solubility is also one of its important physical properties. 2% 2C2% 27 - pyridine - 2% 2C6 - diyldiethanol is soluble in many organic solvents, such as ethanol, acetone, etc., just like fish get water, and the two are inseparable. However, in water, its solubility is limited, only slightly soluble, just like oil floating in water, difficult to integrate.
In terms of density, it is about [specific value] g/cm ³, which is slightly heavier than water. If it is co-located with water, it will slowly sink and sink to the bottom.
In addition, it has a certain viscosity, and when touched, it feels sticky, just like the thickness of honey. This property can play a unique role in specific industrial processes.
In summary, the physical properties of 2% 2C2% 27 - pyridine - 2% 2C6 - diyldiethanol are of great significance in many fields such as chemicals and materials. In-depth understanding of it can make good use of it to maximize its effectiveness.
What are the chemical properties of 2,2 '-pyridine-2,6-diyldiethanol?
2% 2C2% 27 -pyridine - 2% 2C6 -diyldiethanol, Chinese name or 2,2 '-pyridine-2,6-diyl diethanol. This material has unique chemical properties. It has the characteristics of alcohols and can participate in the esterification reaction because it contains two alcohol hydroxyl groups. In the case of carboxylic acids, under suitable catalysts and conditions, hydroxyl hydrogen and carboxyl hydroxyl groups combine to form water to form corresponding esters. This reaction may be used to prepare specific organic compounds.
Furthermore, the pyridine ring gives it a certain alkalinity. The nitrogen atom of the pyridine ring has lone pairs of electrons, which can accept protons and can form salts when it encounters acids. This property may help it interact with acidic groups in pharmaceutical chemistry, changing the properties and activities of drug molecules.
From the perspective of spatial structure, the pyridine ring is connected to two ethanol groups, or the molecule has a certain polarity, which affects its solubility. In organic solvents, due to the principle of similar miscibility, it may have better solubility; in water, due to the presence of polar groups, it also has certain solubility, but the specific solubility is affected by factors such as temperature and solvent ratio.
In addition, the covalent bond properties between carbon, hydrogen, oxygen and nitrogen atoms in the molecule are stable, but under the action of strong oxidants or reducing agents, bond breakage and structural changes may occur. Strong oxidants such as potassium permanganate or alcohol hydroxyl groups cause structural changes; strong reducing agents may affect the pyridine ring, changing its electron cloud distribution and chemical activity.
In summary, 2,2 '-pyridine-2,6-diyl diethyl alcohol has chemical properties such as esterification, acidity and alkalinity, and specific solubility due to the structure of the alcohol hydroxyl group and pyridine ring, which may have potential uses in organic synthesis, drug development and other fields.
What is the synthesis method of 2,2 '-pyridine-2,6-diyldiethanol
To prepare 2,2 '-pyridine-2,6-diyldiethyl alcohol, the method is as follows:
First take pyridine-2,6-dicarboxylic acid, combine it with a suitable reducing agent, such as lithium aluminum hydride, in a suitable organic solvent, such as anhydrous ethyl ether, in a low temperature and nitrogen protected environment, carefully react. Pyridine-2,6-dicarboxylic acid meets lithium aluminum hydride, the carboxyl group is reduced, and 2,6-bis (hydroxymethyl) pyridine can be obtained through this step.
Then, 2,6-bis (hydroxymethyl) pyridine is reacted with ethylene oxide in a reaction kettle at a certain temperature and pressure in the presence of a basic catalyst, such as sodium hydroxide. Catalyzed by alkali, ethylene oxide is ring-opened and nucleophilic substituted with the hydroxyl methyl group of 2,6-bis (hydroxymethyl) pyridine to obtain 2,2 '-pyridine-2,6-diyl diethyl alcohol.
After the reaction is completed, the impurities are removed by conventional separation and purification methods, such as vacuum distillation, recrystallization, etc., to obtain a pure product. This synthesis method has clear steps and controllable conditions, and the desired compound can be obtained.
In which fields is 2,2 '-pyridine-2,6-diyldiethanol used?
2% 2C2% 27 - pyridine - 2% 2C6 - diyldiethanol, Chinese name or 2,2 '-pyridine-2,6-diyldiethanol, this substance is used in many fields.
In the field of medicine, it may be used as an intermediate in drug synthesis. Due to its special chemical structure, it can introduce specific active groups to drug molecules, which helps to build complex drug structures, such as participating in the development of compounds with specific pharmacological activities, or acting on specific targets for disease treatment.
In the field of materials science, it can participate in the synthesis of polymer materials. By reacting with other monomers to form polymers with special properties, such as improving material solubility, thermal stability, etc., it can be used to make high-performance plastics and fibers, and is used in aerospace, electronic equipment and other industries that require strict material properties.
In the field of organic synthesis, it is an important organic reagent. In organic reactions, or as ligands, coordinate with metal ions to catalyze specific organic reactions, improve reaction selectivity and efficiency, promote the development of organic synthesis chemistry, and achieve efficient synthesis of complex organic compounds.
In the field of daily chemicals, or used in cosmetics and detergent formulations. With its special chemical properties, it can play the role of emulsification, solubilization, etc., improve product stability and performance, such as making cosmetics more uniform texture and detergent decontamination ability.
In summary, 2,2 '-pyridine-2,6-diyl diethyl alcohol plays an important role in the fields of medicine, materials, organic synthesis, daily chemicals, etc., and has far-reaching impact on the development of various industries.