2 2 Methylamino Ethyl Pyridine
pyridine pyrrole pyrazine piperidine piperazine

2-(2-(Methylamino)ethyl)pyridine

    Specifications

    HS Code

    899059

    Chemical Formula C8H12N2
    Molar Mass 136.194 g/mol
    Appearance Liquid (predicted)
    Boiling Point 218 - 220 °C at 760 mmHg (predicted)
    Density 1.01 g/cm³ (predicted)
    Water Solubility Soluble (predicted based on structure)
    Flash Point 94.5 °C (predicted)
    Logp 0.94 (predicted)
    Pka 8.64 (predicted)

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    General Information
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    Frequently Asked Questions

    As a leading 2-(2-(Methylamino)ethyl)pyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2- (methylamino) ethyl) pyridine?
    2- (2- (methylamino) ethyl) amine, its main use is in the field of medicinal chemistry. This compound can be used as a key intermediate in the synthesis of many drugs, and can participate in the construction of specific structures of drug molecules, thereby endowing drugs with specific physiological activities and therapeutic effects.
    It plays a key role in the development of drugs for the nervous system. For example, some drugs that act on the neurotransmitter system will use 2- (2- (methylamino) ethyl) amine as a starting material or key intermediate in the synthesis process. Through chemical modification and structural optimization, the synthesized drugs can precisely act on specific receptors on nerve cells, regulate neurotransmission functions, and treat neurological diseases such as depression and anxiety.
    In the field of cardiovascular drugs, it can also be seen. It can be used to synthesize drugs that regulate the function of the cardiovascular system, such as some drugs that can act on the cardiac ion channel or angiotensin system. With the help of precise regulation of cardiovascular physiological processes, the purpose of treating cardiovascular diseases such as hypertension and arrhythmia can be achieved.
    In addition, in the development of antibacterial drugs, 2- (2- (methylamino) ethyl) amine can also introduce special groups into drug molecules, enhance the ability of drugs to bind to bacterial targets, thereby enhancing antibacterial activity and facilitating the creation of new antibacterial drugs. In short, this compound is of great significance in the field of drug synthesis and provides an important material basis for the development of therapeutic drugs for many diseases.
    What are the physical properties of 2- (methylamino) ethyl) pyridine?
    2-%282-%28%E7%94%B2%E5%9F%BA%E6%B0%A8%E5%9F%BA%29%E4%B9%99%E5%9F%BA%29%E5%90%A1%E5%95%B6, this is one of the organic compounds. Looking at its structure, it can be seen that its properties are unique.
    In terms of physical properties, such compounds usually have certain volatility. Its boiling point is related to the intermolecular force. Due to the specific group in the molecular structure, the intermolecular force shows certain characteristics, and the boiling point may be within a specific range. Under normal temperature and pressure, it is either liquid or has a low melting point, which is easy to melt by heat. And in common organic solvents, it may have good solubility. Due to the similar principle of miscibility, its molecular structure is compatible with the structure of organic solvents, so that the two can miscible with each other.
    As for chemical properties, some groups in the 2-%282-%28%E7%94%B2%E5%9F%BA%E6%B0%A8%E5%9F%BA%29%E4%B9%99%E5%9F%BA%29%E5%90%A1%E5%95%B6 have higher reactivity. Such as some of the chemical bonds, under suitable conditions, can be broken and recombined. Taking the reaction with electrophilic reagents as an example, the area with high electron cloud density in the molecule is vulnerable to attack by electrophilic reagents, thereby triggering reactions such as substitution and addition. And because of the specific functional groups in its structure, it also has unique performance in redox reactions, or it can be used as a reducing agent to provide electrons for other substances and undergo oxidation reactions by itself; or under specific conditions, it can be reduced by accepting electrons as an oxidizing agent. In addition, in the case of alkaline or acidic environments, acid-base neutralization or other related chemical reactions will also occur due to the characteristics of functional groups, resulting in changes in molecular structure and properties.
    What are the synthesis methods of 2- (2- (methylamino) ethyl) pyridine?
    To prepare 2 - (2 - (methyl hydroxyl) ethyl) pyridine, there are many ways to synthesize it. I will describe it here.
    First, using pyridine as the starting material, pyridine first reacts with halogenated acetaldehyde dimethanol under the catalysis of a base. After nucleophilic substitution, the nitrogen atom of the pyridine ring attacks the halogenated atom of halogenated acetaldehyde dimethanol to form the corresponding pyridine substituent. Subsequently, the acetal structure is hydrolyzed under acidic conditions to obtain a pyridine derivative containing an aldehyde group. This derivative undergoes nucleophilic addition reaction with methyl Grignard reagent or methyl lithium reagent, and the aldehyde group is converted into a hydroxyl group, and methyl groups are introduced, and finally the synthesis of 2 - (2 - (methyl hydroxyl) ethyl) pyridine is achieved.
    Second, it can start from 2-vinylpyridine. 2-vinylpyridine is first epoxidized with peroxy acid to form an epoxy pyridine derivative. Next, the epoxy ring is opened under the action of a nucleophilic reagent, and methanol is used as a nucleophilic reagent. Under the catalysis of a suitable catalyst, the oxygen atom of methanol attacks the epoxy ring and introduces a methoxy group. Subsequently, through a reduction reaction, the methoxy group is reduced to a hydroxyl group to obtain the target product.
    Third, the 2- (2-chloroethyl) pyridine is used as a raw material and reacts with alkoxides such as sodium methoxide to undergo nucleophilic substitution, and the chlorine atom is replaced by a methoxy group. The subsequent reduction step converts the methoxy group into a hydroxyl group, and 2- (2- (methyl hydroxyl) ethyl) pyridine can also be obtained.
    During the synthesis process, the reaction conditions, such as temperature, pH, reaction time and ratio of reactants, need to be carefully adjusted according to the characteristics of each reaction step, in order to improve the yield and purity of the product, so that the synthesis can proceed smoothly.
    What are the precautions for 2- (2- (methylamino) ethyl) pyridine in storage and transportation?
    When preparing 2- (2- (methoxyethoxy) ethyl) amine for storage and transportation, many matters need to be paid attention to.
    For storage, this substance should be stored in a cool and ventilated warehouse. Because it may have a certain chemical activity, high temperature is easy to cause chemical reactions, so it is necessary to keep away from fire and heat sources. The temperature of the warehouse should be controlled in a suitable range to prevent temperature fluctuations from changing the properties of the substance. At the same time, it should be stored separately from oxidants and acids to avoid mixed storage. Due to its chemical structure characteristics, contact with these substances may trigger violent reactions, which is very harmful. The storage area should be equipped with suitable materials to contain leaks, so as to prevent accidental leaks from being handled in time and reduce hazards.
    In terms of transportation, it is necessary to strictly follow the relevant regulations on the transportation of hazardous chemicals. Before transportation, ensure that the packaging is complete and well sealed to prevent leakage during transportation. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. During driving, avoid exposure to the sun, rain, and high temperature. During transportation, drive according to the specified route and do not stop in residential areas and densely populated areas. If there is a leakage during transportation, emergency measures should be taken immediately to evacuate the surrounding people to prevent the occurrence of poisoning and other hazards, and timely notify the relevant professional departments to deal with it. In short, whether it is storing or transporting 2 - (2 - (methoxyethoxy) ethyl) amine, it is necessary to strictly follow the regulations and pay attention to every detail to ensure the safety of personnel and the environment from pollution.
    What are the effects of 2- (2- (methylamino) ethyl) pyridine on the environment and human health?
    Fu 2 - (2 - (methoxyethoxy) ethyl) This substance has a complex impact on the environment and human health, and needs to be reviewed in detail.
    As far as the environment is concerned, it may have different behaviors in natural water bodies, soils, and atmospheres. If it flows into water bodies, or due to its own chemical characteristics, it interferes with the normal metabolism of aquatic organisms. Coating aquatic organisms are extremely sensitive to water quality components. This substance may change the chemical balance of water bodies, causing abnormal growth of algae, which in turn affects the bottom organisms of the food chain, and conduction layer by layer, endangering the stability of the entire aquatic ecosystem. In the soil, it may interact with soil particles, change the physical and chemical properties of the soil, affect the uptake of nutrients by plant roots, and hinder plant growth and development. In the atmospheric environment, although its volatilization may be limited, once it enters the atmosphere, it will have a negative impact on air quality through complex processes such as photochemical reactions, or participate in the generation of secondary pollutants.
    As for human health, exposure routes are diverse, either absorbed through the skin, ingested by breathing, or ingested by mistake. When exposed to the skin, some people may experience allergic reactions, and the skin is red, itchy, and rash. If it enters the human body through breathing, it reaches the respiratory tract and lungs, or irritates the mucosa of the respiratory tract, causing symptoms such as cough and asthma. Long-term exposure may damage the normal function of the lungs. After ingestion, it may cause digestive system disorders, nausea, vomiting, abdominal pain, etc., and in severe cases, it may damage important organs such as the liver and kidneys. Because it needs to be metabolized by the liver and excreted by the kidneys, it will increase the burden on the organs. Over time, organ function may be irreversibly damaged.
    Therefore, this 2 - (2 - (methoxyethoxy) ethyl) substance, whether it is environmental maintenance or personal health protection, needs to be paid enough attention to, and its influence mechanism should be deeply explored in order to find appropriate countermeasures.