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What is the chemical structure of the compound 2- {[2-methyl-3- (trifluoromethyl) phenyl] amino} pyridine-3-carboxylic acid - 1-deoxy-1- (methylamino) -D-glucitol (1:1)?
The name of this compound is 2 - {[2-methyl-3- (trifluoromethyl) phenyl] amino} pyridine-3-carboxylic acid-1-deoxy-1- (methylamino) -D-glucitol (1:1). Its chemical structure is described below in the style of the ancient saying of "Tiangong Kaiwu":
This compound is based on pyridine, at the second position of pyridine, connected with a group of {[2-methyl-3- (trifluoromethyl) phenyl] amino}. Above this phenyl group, there are methyl groups in the binary position, trifluoromethyl groups are connected in three places, and the amino group is connected between the phenyl group and the pyridine group, which is like a bridge to communicate the two. And in the three places of pyridine, it is connected with the carboxylic acid group.
There is also 1-deoxy-1- (methylamino) -D-glucitol combined with it in a ratio of 1:1. The structure of D-glucitol is in the shape of a six-membered carbon ring, which is like a jade ring formed in heaven. Deoxidized at 1 position, and connected with methylamino and methylamino, the methyl group is connected to the amino group.
The two are connected in a specific way, with a delicate structure, just like those made by heaven. Each group is in its own place and interacts to form this unique chemical structure, revealing the wonders of chemistry and the delicate mysteries of material composition.
What are the physical properties of 2- {[2-methyl-3- (trifluoromethyl) phenyl] amino} pyridine-3-carboxylic acid - 1-deoxy-1- (methylamino) -D-glucitol (1:1)?
2-% 7B% 5B2 - methyl - 3 - (trifluoromethyl) phenyl%5Damino%7Dpyridine - 3 - carboxylic acid - 1 - deoxy - 1 - (methylamino) -D - glucitol (1:1), this is a special chemical compound. Its physical properties are unique and related to many factors.
When it comes to morphology, this compound is often solid, and its microstructure is arranged in an orderly manner, resulting in a relatively stable macroscopic morphology. The color is mostly white or nearly white, and the sense of purity is full.
In terms of solubility, in organic solvents, such as common ethanol and acetone, it shows a certain solubility. The polarity of ethanol molecules interacts with some of the groups of the compound, making it dispersible under suitable conditions. However, in water, the solubility is not good, because the hydrophobic part of the molecular structure accounts for a large proportion, it is difficult for water molecules to fully affinity with it.
Melting point is also an important physical property. Experiments have determined that its melting point is in a specific temperature range. At this temperature, the intermolecular force is weakened, the lattice structure begins to disintegrate, and the solid state gradually changes to the liquid state. This transition temperature provides a reference for the application of the compound in different environments.
In addition, the density cannot be ignored. It reflects the mass per unit volume of a substance, and has guiding significance for container selection and space utilization during preparation, storage and transportation.
The above physical properties are all key factors to consider when studying, producing, and applying this compound, helping researchers better grasp its characteristics and laying the foundation for the development of related fields.
2- {[2-methyl-3- (trifluoromethyl) phenyl] amino} pyridine-3-carboxylic acid - 1-deoxy-1- (methylamino) -D-glucitol (1:1) is used in what fields?
2-% {[2-methyl-3- (trifluoromethyl) phenyl] amino} pyridine-3-carboxylic acid-1-deoxy-1- (methylamino) -D-glucitol (1:1), this is a special chemical compound, which has extraordinary applications in the fields of medicine, agriculture and materials science.
In the field of medicine, because of its unique structure or specific biological activity, it can precisely interact with biological macromolecules in the body. For example, it can be used as a new drug lead compound, which can be further studied and optimized, or innovative drugs for specific diseases can be developed. It can either regulate the activity of specific enzymes in the body and correct the metabolic imbalance in pathological states; or it binds to cell surface receptors to regulate cell signaling pathways, and has potential value in the treatment of major diseases such as cancer and cardiovascular diseases.
In the field of agriculture, it may be used to develop new pesticides. Its unique chemical structure may endow high selective inhibition or killing ability against specific pests and pathogens, and it is relatively friendly to the environment. It can not only effectively protect crops from pests and diseases, ensure food yield and quality, but also reduce the negative impact of traditional pesticides on the ecological environment, which is in line with the current needs of green agriculture development.
In the field of materials science, this compound may be used as a key component of functional materials. With its special chemical and physical properties, or endow materials with unique properties. Such as adding in polymer materials, or improving the thermal stability and mechanical properties of materials, or endowing materials with special optical and electrical properties, providing new options for the development of electronic devices, optical materials and other fields.
In summary, 2-% {[2-methyl-3- (trifluoromethyl) phenyl] amino} pyridine-3-carboxylic acid-1-deoxy-1- (methylamino) -D-glucitol (1:1) has shown broad application prospects in many fields, and is expected to bring new opportunities for the development of various fields.
What is the synthesis method of 2- {[2-methyl-3- (trifluoromethyl) phenyl] amino} pyridine-3-carboxylic acid - 1-deoxy-1- (methylamino) -D-glucitol (1:1)?
To prepare 2 - {[2 - methyl - 3 - (trifluoromethyl) phenyl] amino} pyridine - 3 - carboxylic acid - 1 - deoxy - 1 - (methylamino) -D - glucitol (1:1), the following ancient method can be used. < Br >
First take 2-chloropyridine-3-carboxylic acid, with 2-methyl-3- (trifluoromethyl) aniline, with an appropriate amount of potassium carbonate as acid binding agent, in N, N-dimethylformamide (DMF) solvent, heat and stir to make it nucleophilic substitution reaction. The temperature is about 100-120 ° C. When the reaction number is reached, the feed peak in the reaction solution is almost invisible in the liquid chromatography monitoring, and it is cooled to room temperature. The reaction solution was diluted with water, then extracted with ethyl acetate several times, the organic phases were combined, dried with anhydrous sodium sulfate, filtered, and the solvent was evaporated under reduced pressure to obtain 2- {[2-methyl-3- (trifluoromethyl) phenyl] amino} pyridine-3 -carboxylic acid crude product, purified by column chromatography for later use.
Take another 1-deoxy-1- (methylamino) -D-gluconol, dissolve in an appropriate amount of methanol, purify the above-mentioned 2- {[2-methyl-3- (trifluoromethyl) phenyl] amino} pyridine-3 -carboxylic acid is also dissolved, an appropriate amount of p-toluenesulfonic acid is added as a catalyst, and the reaction is stirred at 50-60 ° C. During this period, the reaction process was monitored by thin-layer chromatography at regular intervals. When the raw materials were fully reacted, the methanol was evaporated under reduced pressure, and the residue was dissolved with an appropriate amount of dichloromethane. The residue was washed with water, saturated sodium bicarbonate solution, and water. The organic phase was dried with anhydrous sodium sulfate, filtered, and the solvent was evaporated to obtain the target product. After re-crystallization, careful operation with a suitable solvent, such as an ethanol-water mixed solvent, can obtain a high purity of 2 - {[2-methyl-3- (trifluoromethyl) phenyl] amino} pyridine-3-carboxylic acid-1-deoxy-1- (methylamino) -D-glucitol (1:1).
What is the safety of 2- {[2-methyl-3- (trifluoromethyl) phenyl] amino} pyridine-3-carboxylic acid - 1-deoxy-1- (methylamino) -D-glucitol (1:1)?
This is a question about the safety of 2- {[2-methyl-3- (trifluoromethyl) phenyl] amino} pyridine-3-carboxylic acid-1-deoxy-1- (methylamino) -D-gluconol (1:1). The safety of this compound is related to many aspects.
In terms of chemical structure, 2- {[2-methyl-3- (trifluoromethyl) phenyl] amino} pyridine-3-carboxylic acid part, containing pyridine ring and specific substituted phenyl groups, such structures may be sensitized and potentially toxic in some compounds. The nitrogen atom activity of the pyridine ring may affect its interaction with molecules in vivo. The 1-deoxy-1- (methylamino) -D-glucitol part is related to the structure of carbohydrates. Although carbohydrates are mostly common components in organisms, this modified sugar structure introduces methylamino groups, or alters their biological activities and metabolic pathways.
From a toxicological point of view, without sufficient research data, it is difficult to know its impact on various systems in organisms. Or there is acute toxicity, such as damage to important organs such as liver and kidney, affecting their normal function. Long-term exposure may also have latent risks such as mutagenicity, teratogenicity, and carcinogenesis, and interfere with the normal transmission and expression of genetic material in cells.
In terms of environmental safety, if it enters the environment, it may accumulate and cause adverse effects on the biodiversity and food chain of the ecosystem due to the presence of fluorine atoms, which may be difficult to degrade in the natural environment.
In summary, due to the lack of specific research data, the safety of this compound is difficult to draw conclusions. Only through rigorous experimental studies, covering toxicology, Environmental Impact Assessment and other fields, can its safety be clarified.