2-(2-Methyl-2H-tetrazol-5-yl)pyridine-5-boronic acid pinacol ester

2-% 282 - Methyl - 2H - tetrazol - 5 - yl% 29pyridine - 5 - boronic acid pinacol ester is an organic compound. It has many chemical properties.
This compound contains a boron ester structure, which endows it with certain reactivity. Boron esters are often used as important intermediates in organic synthesis and can participate in many reactions, such as the Suzuki reaction. In the Suzuki reaction, boron esters can be coupled with halogenated aromatics or halogenated olefins under the action of palladium catalysts and bases, thereby forming carbon-carbon bonds, which are then used in the synthesis of various complex organic molecules, which is of great significance in the fields of medicinal chemistry and materials science.
At the same time, the pyridine ring and tetrazole group in this compound also have a profound impact on its chemical properties. Pyridine ring is aromatic, and the presence of nitrogen atoms makes the electron cloud distribution of pyridine ring unique, which can participate in electrophilic substitution and nucleophilic substitution reactions. Tetrazole group has good stability and certain acidity, and can be complexed with metal ions, which is widely used in the field of coordination chemistry.
In addition, the methyl substituent in the 2-Methyl-2H-tetrazol-5-yl part can affect the electron cloud density of surrounding groups due to the methyl power supply effect, and change the overall reactivity and physical properties of the compound, such as solubility and melting point. Overall, the compound shows potential application value in the fields of organic synthesis, drug development, and material preparation due to its unique structure.

The common methods for synthesizing 2 - (2-methyl-2H-tetrazolium-5-yl) pyridine-5-boronic acid pinacol esters are as follows:
The starting material is selected from 2-halopyridine derivatives and 2-methyl-2H-tetrazolium-5-yl related reagents for coupling reaction. First, the 2-halopyridine derivatives are placed in the reaction vessel, and an appropriate amount of organic solvents, such as toluene, dioxane, etc., are added to create a suitable environment for the reaction. Subsequently, alkali substances such as potassium carbonate and sodium carbonate are added. The function of the base is to adjust the pH of the reaction system and promote the progress of the reaction. Then, 2-methyl-2H-tetrazole-5-based reagents are added. Here, metal catalysts are indispensable, such as palladium catalysts (tetra- (triphenylphosphine) palladium, etc.), which can significantly speed up the reaction rate and improve the reaction yield. Heat the reaction system and maintain a certain temperature, usually between 80 and 120 ° C. The reaction takes several hours to more than ten hours, during which the reaction process is closely monitored.
After the above coupling reaction is completed, the product is preliminarily treated and transferred to the borate esterification step. The reaction solution is cooled, and an appropriate amount of catalyst is added, such as Lewis acid (boron trifluoride ether complex, etc.). The reaction system is heated again, and the temperature is controlled at 60-100 ° C, and the reaction lasts for several hours. During this process, the boric acid and pinacol undergo esterification to form the target product 2- (2-methyl-2H-tetrazolium-5-yl) pyridine-5-boronic acid pinacol ester. After the
reaction is completed, the product needs to be separated and purified. The commonly used method is column chromatography, using silica gel as the stationary phase, selecting a suitable eluent, such as the mixed solvent of petroleum ether and ethyl acetate, and achieving the separation of the two according to the difference in the distribution coefficient between the product and the impurity in the stationary phase and the mobile phase, so as to obtain a pure target product.

2-%282-Methyl-2H-tetrazol-5-yl%29pyridine-5-boronic acid pinacol ester is also a chemical substance. Its use, in the field of synthesis, is often used in the field of synthesis. There are synthetic molecules that want to be synthesized, and this compound can be used for multiple reactions, such as catalysis.
It is also important for the research of substances. It is often used by physicists to create the core skeleton of molecules, hoping to create substances with specific biological activities, and to create general diseases. It can be used by ingenious chemical reactions, other compounds, and the integration properties of the whole molecule, such as solubility, lipidinity, etc., which are all important for the absorption, separation, substitution, and excretion of substances.
And in the field of materials, it may also have its own function. It can assist in the research of new functional materials, such as light materials. Because of its special chemical properties, it may make the material exhibit unique light and properties, which adds to the material science. Moreover, 2-%282-Methyl-2H-tetrazol-5-yl%29pyridine-5-boronic acid pinacol ester plays an indispensable role in many fields such as chemical synthesis, material research, and materials science. Scientific research and technology development provide important assistance.

2-% 282 - Methyl - 2H - tetrazol - 5 - yl% 29pyridine - 5 - boronic acid pinacol ester (2 - (2 - methyl - 2H - tetrazol - 5 - yl) pyridine - 5 - boronic acid pinacol ester) is a commonly used reagent in organic synthesis. When storing this substance, pay attention to the following numbers.
First, the control of temperature and humidity. This compound is quite sensitive to temperature and humidity. High temperature will cause its chemical properties to become active or initiate decomposition reactions; if the humidity is too high, water vapor may interact with the substance, affecting its purity and structure. Therefore, it should be stored in a cool and dry place, usually the temperature is 2-8 ° C, and the humidity is preferably maintained at 40% -60%.
Second, store in the shade away from light. Many borate esters are unstable to light, as are 2- (2-methyl-2H-tetrazole-5-yl) pyridine-5-boronic acid pinacol esters. Light or promote photochemical reactions to cause structural changes and reduced activity. Therefore, it should be stored in dark containers such as brown bottles and placed in a dark place.
Third, isolated storage. It needs to be stored separately from oxidants, acids, bases, etc. Because of the borate ester part in its chemical structure, it may react with acid and alkali, destroying its structure; oxidizing agent or causing its oxidation, changing its chemical properties.
Fourth, sealed storage. Oxygen in the air reacts weakly with carbon dioxide or the compound, and long-term contact or quality is affected. Sealed storage can reduce contact with air and ensure its stability. In conclusion, when storing 2 - (2 - methyl - 2H - tetrazole - 5 - yl) pyridine - 5 - boronic acid pinacol ester, attention should be paid to temperature and humidity, light, isolation and sealing in order to maintain its chemical stability and purity, so that it can play its due role in organic synthesis.

I don't know the market price of "2- (2-Methyl-2H-tetrazol-5-yl) pyridine-5-boronic acid pinacol ester". This compound is not widely known and common, and its price is often determined by many factors.
First, purity is the key factor. If the purity is extremely high, it is almost perfect, and it is used in high-end scientific research experiments, the preparation process required is complicated and expensive, and the price will be high. On the contrary, if the purity is slightly lower, it is used in general research or industrial production auxiliary links, and the price is relatively close to the people.
Second, the amount of output affects the price. If it is mass-produced, the unit cost may be reduced by virtue of the scale effect, and the price will also decrease. However, if only a small amount of customization is used, there is no scale benefit, and the preparation cost is shared, the price will be higher.
Third, the market supply and demand relationship is an important factor. If many scientific research institutions or enterprises have strong demand for this product and limited supply, the price will naturally rise. On the contrary, if the market demand is low and the supply is sufficient, the price will go down.
Fourth, the difficulty of preparation also affects. If the preparation process requires special reagents, complex reaction steps or harsh reaction conditions, the cost will increase and the price will also rise.
To know the exact market price, you can consult professional chemical reagent suppliers, because they are often aware of market dynamics and can provide accurate quotations based on real-time situations. Or refer to the information of the relevant chemical product trading platform, but the price involved may vary due to factors such as platform and time, and it needs to be screened in detail.