2,2'-dithiobis(5-nitropyridine)

2% 2C2% 27 - dithiobis% 285 - nitropyridine% 29, which is 2,2 '-disulfide (5-nitropyridine), is widely used. In the field of biochemical research, it is often used as a protein thiol reagent. Due to its unique structure, it can specifically react with thiol groups in proteins, so as to explore the relationship between protein structure and function. For example, thiol groups in proteins are often located in the active center, which is crucial for the maintenance of their activity. Reaction with 2,2' -disulfide (5-nitropyridine) may change protein activity, helping researchers to understand the role of thiol groups in the realization of protein function.
In the field of organic synthesis, it is also an important reagent. It can participate in the reaction of constructing sulfur-containing and nitrogen-containing heterocyclic compounds. Using it as a raw material and through specific reaction steps, novel heterocyclic products can be obtained. Such heterocyclic compounds have potential application value in the field of medicinal chemistry, or can be developed into new drugs for disease treatment.
In addition, it has attracted more and more attention in the field of materials science. Or it can be used to prepare functional materials, with its ability to react with specific groups, endowing materials with unique properties, such as adsorption and recognition of specific substances, and opening up new paths for the creation of new functional materials. In short, 2,2 '-disulfide bis (5-nitropyridine) has important uses in many fields, promoting scientific research and technological development in various fields.

2% 2C2% 27 - dithiobis% 285 - nitropyridine% 29, that is, 2,2 '-disulfide (5-nitropyridine), the physical properties of this substance are as follows:
Its appearance is often yellow to orange crystalline powder. It is relatively stable at room temperature and pressure, and it may react dangerously in case of hot topic, open flame or strong oxidant.
The melting point is about 149-153 ° C. This property can be used to identify and purify this substance. In organic solvents, its solubility presents certain characteristics. In common organic solvents such as dichloromethane and chloroform, it has good solubility and can form a clear solution; in water, its solubility is poor. Because its molecular structure contains hydrophobic pyridine rings and nitro groups, the interaction between water molecules is weak, so it is difficult to dissolve.
In addition, the substance has a certain degree of hygroscopicity, and in humid environments, it may absorb certain water. Because its structure contains sulfur atoms and nitro groups, under specific conditions, it may participate in oxidation-reduction reactions, nucleophilic substitution reactions, etc., which may also have indirect effects on its physical properties. The physical properties of this substance lay an important foundation for its application in chemical, pharmaceutical and other fields.

2% 2C2% 27 - dithiobis% 285 - nitropyridine% 29, the Chinese name is often 2,2 '-disulfide bis (5-nitropyridine). The chemical properties of this substance are as follows:
Looking at its properties, at room temperature, it is usually solid, the color is light yellow or nearly white, and the appearance is mostly powdery, fine and uniform. Its solubility is quite specific. It is slightly soluble in common organic solvents such as ethanol and dichloromethane, but it is almost insoluble in water. This is due to the small number of hydrophilic groups in the molecular structure and the large number of hydrophobic parts.
When it comes to chemical activity, the intramolecular disulfide bond is very reactive. When exposed to reducing agents such as dithiothreitol (DTT), this disulfide bond can be easily broken to form corresponding thiol compounds. This property is widely used in the fields of biochemistry and organic synthesis, and is often used as a switch for redox response. Moreover, the presence of nitro groups on the pyridine ring makes its electron cloud density different, making the pyridine ring more susceptible to attack by nucleophiles, and then nucleophilic substitution reactions occur. It can be used as a key intermediate in the construction of complex organic molecular systems.
When heated, the stability of 2,2 '-disulfide bis (5-nitropyridine) gradually loses, the disulfide bond breaks first, and the nitro group may also decompose and other complex reactions. The products are mostly sulfur-containing and nitrogen-containing small molecule compounds. This process is often accompanied by energy release. However, due to the complex reaction conditions and products, careful temperature control and attention to the reaction process are required in practical applications.

2% 2C2% 27 - dithiobis% 285 - nitropyridine% 29 is 2,2 '-disulfide bis (5-nitropyridine), and its synthesis method is as follows:
To prepare 2,2' -disulfide bis (5-nitropyridine), 5-nitropyridine-2-mercaptan can be taken as the starting material. Place an appropriate amount of 5-nitropyridine-2-mercaptan in a suitable reaction vessel, add an appropriate amount of base, such as sodium hydroxide or potassium hydroxide aqueous solution, and stir to fully react 5-nitropyridine-2-mercaptan with the base to generate the corresponding mercaptan salt. This step aims to convert the mercaptan into a more nucleophilic mercaptan salt to facilitate subsequent reactions.
Then, slowly add a mild oxidizing agent to the above reaction system, usually an organic solution of elemental iodine ($I_2 $). The dropwise addition process needs to be careful, and the stirring should be continued to ensure that the reaction proceeds uniformly. With the addition of the oxidizing agent, an oxidative coupling reaction occurs between the thiols, and 2,2 '-disulfide (5-nitropyridine) is gradually formed. During the reaction process, the reaction progress can be monitored by means of thin layer chromatography (TLC). When the raw material point disappears, the reaction is basically completed.
After the reaction is completed, the reaction mixture is post-treated. First, an appropriate amount of water is added to the system to dilute, and then an organic solvent such as dichloromethane or ethyl acetate is used for extraction. Multiple extractions are carried out to fully extract the product. The organic phases are combined and dried with a desiccant such as anhydrous sodium sulfate to remove the moisture in the organic phase. Then, the organic solvent is removed by reduced pressure distillation to obtain a crude product.
Finally, the crude product is purified. Column chromatography can be used, using silica gel as the stationary phase, selecting a suitable eluent, such as a solution of petroleum ether and ethyl acetate mixed in a certain proportion, column chromatography can be used to separate, collect the fraction containing the pure product, and volatilize to remove the eluent to obtain a pure 2,2 '-disulfide (5-nitropyridine).
Another approach can be tried, using 2-halo-5-nitropyridine and sodium disulfide as raw materials. Sodium disulfide is first prepared into a solution of suitable concentration, 2-halo-5-nitropyridine is slowly added to it, and the reaction is stirred at an appropriate temperature. This reaction is based on a nucleophilic substitution mechanism, in which halogen atoms are replaced by disulfide anions to form the target product. Subsequent post-treatment and purification steps are similar to the previous ones. After extraction, drying, distillation, column chromatography, etc., 2,2 '-disulfide bis (5-nitropyridine) can also be obtained.

2% 2C2% 27 - dithiobis% 285 - nitropyridine% 29, chemical substances are also used.
First, this substance is toxic. If it is used, it must be prevented from contact with the skin and the eyes. If it is accidentally contaminated with the skin, it is advisable to wash it with a lot of water as soon as possible, and it will be treated immediately. If it enters the eyes, it is even more necessary to wash it with a lot of water immediately, and ask for help as soon as possible.
Second, its taste is not good, or it is irritating, and it is advisable to use it for good. In this way, it can prevent the user from inhaling harmful substances, keep their breathing and body healthy.
Third, this material is not good or disturbing, and light and other factors may cause it to melt.
Fourth, the utensils used are dry and dry, and they are protected from light, so as to ensure that the product is not damaged.
Fourth, the utensils used are dry and dry, so as not to cause the opposite of the damage and affect the effect. After use, the damaged things should also be properly handled according to the corresponding conditions, and should not be poured down by accident, so as not to dye the environment.
Fifth, the user must be familiar with its properties, methods of use and unexpected measures. In this way, it is possible to use this thing safely and effectively, and avoid danger before it occurs. Therefore, be careful and operate according to the rules, and use 2% 2C2% 27 - dithiobis% 285 - nitropyridine% 29.