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What is the chemical structure of 2- (2- (dimethylamino) ethyl) (p-methoxybenzyl) amino) pyridine?
This is an organic compound whose name is 2 - {[ (2 - (dimethylamino) ethyl) (p-methoxybenzyl) amino] pyridine}. To clarify its chemical structure, follow the principles of organic chemistry and analyze its name to know the approximate structure.
The first view of "pyridine", which is a six-membered nitrogen-containing heterocycle, is aromatic, and is the core skeleton of the compound. The "2 -" epitope is attached to the second position of the pyridine ring.
Look again at the "{[ (2 - (dimethylamino) ethyl) (p-methoxybenzyl) amino]}" part. " ( 2 - (dimethylamino) ethyl) ", the second carbon of ethyl is connected with dimethylamino, that is, the structure of -CH ³ CH ³ N (CH < unk >) ³." (p-methoxybenzyl) ", benzyl is benzyl, -CH < unk > -is connected to the benzene ring, and the" p-methoxy "epiphenyl ring has methoxy-OCH < unk >, that is, -CH < unk > - C < unk > - OCH < unk > (para). The two are connected by amino-NH-to form the -NH-CH -2-C H -OCH
The chemical structure of the compound is based on the pyridine ring as the core, and the second position is connected with a complex substituent, which is composed of dimethylaminoethyl and p-methoxybenzyl. This structure makes the compound have both the properties of the pyridine ring and the characteristics imparted by the substituent, and may have important uses in organic synthesis, medicinal chemistry and other fields.
What are the physical properties of 2- (2- (dimethylamino) ethyl) (p-methoxybenzyl) amino) pyridine?
2-%28%282-%28dimethylamino%29ethyl%29%28p-methoxybenzyl%29amino%29pyridine, this is an organic compound, and its physical properties are particularly important, which is described in detail by you.
First, the appearance is often colorless to light yellow liquid. The appearance of this color state is related to the arrangement of atoms in its molecular structure and the distribution of electron clouds. It has a specific smell, but the description of this smell needs to be based on the actual smell experience, which is roughly a certain stimulating organic smell.
About its melting point, the melting point is low, and it is usually at room temperature, so it is mostly liquid. The boiling point is relatively high, because there are interactions such as van der Waals force and hydrogen bonds between molecules. To make molecules break free from the liquid phase, more energy is required. < Br >
In terms of solubility, the compound has good solubility in organic solvents such as ethanol and acetone, because its molecular structure is consistent with the principle of similar miscibility of organic solvents. However, its solubility in water is limited, because there are relatively few hydrophilic groups in the molecule, and the hydrophobic part accounts for a large proportion.
Density is also one of the important physical properties. Its density is slightly higher than that of water. When mixed with water, it can be seen that it sinks to the bottom of the water.
In addition, the stability of the compound is acceptable under certain conditions. In case of special environments such as high temperature and strong oxidants, the molecular structure may change, triggering chemical reactions. < Br >
The physical properties of this compound are determined by its unique molecular structure, and the properties are also interrelated, which is of key significance in chemical research and practical applications.
What are the common uses of 2- (2- (dimethylamino) ethyl) (p-methoxybenzyl) amino) pyridine?
2-%28%282-%28dimethylamino%29ethyl%29%28p-methoxybenzyl%29amino%29pyridine, chemical compounds are also used. These compounds are often used in multiple fields and have multiple uses.
In the field of research, they may be important in the synthesis of chemical compounds. Because the molecule contains a specific base, it can be modified by chemistry and introduced into other active parts to build molecules with specific biological activities. or involved in controlling the activity of specific organisms and enzymes, and the purpose of treating diseases.
In the field of materials, it may also exhibit special properties. Its molecules or give materials special physical and chemical properties, such as optical properties, properties, etc. It can be used in the research of optical materials, such as optical diodes (OLEDs), solar cells and other phase materials.
Furthermore, in chemical research, this compound may be used as a compounding agent. Because of its nitrogen-containing coordination atoms, it can form complexes of gold particles, which can be used in catalytic reactions. It can improve the activity and performance of catalysis, promote more efficient and efficient reactions, and help to refine and efficiency of chemical synthesis.
In this way, 2-%28%282-%28dimethylamino%29ethyl%29%28p-methoxybenzyl%29amino%29pyridine, materials, and chemical fields are all important, and provide assistance for scientific research and development.
What are the synthesis methods of 2- (2- (dimethylamino) ethyl) (p-methoxybenzyl) amino) pyridine?
To prepare 2 - {[ (2 - (dimethylamino) ethyl) (p-methoxybenzyl) amino] pyridine, there are many methods, and each has its advantages and disadvantages, so it is necessary to choose according to the actual situation.
First, using pyridine as a group, first react the pyridine with an appropriate halogenated reagent, and introduce a leaving group, such as a halogen atom, into the pyridine 2-position to prepare 2-halogenated pyridine. This halogenated pyridine has good activity and can undergo nucleophilic substitution with (2 - (dimethylamino) ethyl) (p-methoxybenzyl) amine. During the reaction, a suitable base needs to be selected to assist in the formation and reaction of nucleophilic reagents, such as potassium carbonate, triethylamine, etc. This base can take hydrogen from the amine group, increase its nucleophilicity, accelerate nucleophilic substitution, and obtain the target product.
Second, a pyridine ring can be constructed first. A compound containing nitrogen and suitable carbon chains is used as the raw material to form a pyridine ring through multi-step reaction cyclization. For example, a β-dicarbonyl compound is used with ammonia or nitrogen-containing derivatives as the starting material to react into a pyridine ring through condensation, cyclization, etc. After cyclization, a (2- (dimethylamino) ethyl) (p-methoxybenzyl) amino group is introduced at the 2-position of the pyridine ring. This introduction process may also involve nucleophilic substitution, condensation and other reactions. The reaction conditions and reagents need to be carefully selected to achieve the ideal yield and selectivity.
Third, or the coupling reaction catalyzed by transition metals can be used. For example, in the palladium-catalyzed amination reaction, 2-halopyridine is used as the substrate, (2- (dimethylamino) ethyl) (p-methoxybenzyl) amine is used as the amine source, and the carbon-nitrogen bond is constructed in the presence of palladium catalyst, ligand and base. The palladium catalyst has high activity and good selectivity, which can effectively promote the reaction. The ligand can regulate the electronic and spatial properties of the catalyst to optimize the reaction activity and selectivity. Bases play multiple roles in the reaction, such as assisting in the generation of active palladium species and neutralizing acids.
However, regardless of the method, it is necessary to pay attention to the optimization of reaction conditions, such as temperature, time, and the proportion of reactants, in order to improve the yield and purity of the product. And the toxicity, cost and difficulty of post-treatment of the reagents used in each method are also key factors to be considered in the actual synthesis.
What are the precautions for using 2- (2- (dimethylamino) ethyl) (p-methoxybenzyl) amino) pyridine?
2-%28%282-%28dimethylamino%29ethyl%29%28p-methoxybenzyl%29amino%29pyridine is an organic compound, and all precautions should be taken when using it.
First, safety protection is the key. This compound may be toxic and irritating, and protective equipment must be comprehensive when exposed. When operating, wear laboratory clothes, gloves and goggles to prevent it from coming into contact with the skin and eyes. If you come into contact accidentally, rinse with plenty of water immediately and seek medical treatment according to the specific situation. It is also necessary to operate in a well-ventilated environment. It is best to do it in a fume hood to avoid inhaling its volatile aerosols or dust, so as not to damage the respiratory system.
Second, storage conditions should also be paid attention to. Store in a cool, dry and ventilated place, away from fire sources and oxidants. Improper storage or deterioration of compounds, affecting their performance, or even causing safety accidents. When storing, the label must be clear, indicating the name of the compound, properties, danger warnings and other key information, so that access and management.
Third, accurate operation cannot be ignored. Before use, its properties and reaction characteristics should be fully understood. In chemical reactions, strict control of reaction conditions, such as temperature, pH, reaction time, etc., will affect the reaction results. According to specific reaction requirements, accurately measure the amount of compounds to ensure the accuracy and repeatability of the reaction. During the experiment, carefully observe the reaction phenomenon, and take timely measures in case of abnormal situations.
Fourth, waste disposal must also be in compliance. After use, the remaining compounds and reaction waste should not be discarded at will. Classified collection and treatment should be carried out in accordance with relevant regulations and laboratory regulations. Organic waste usually needs to be collected centrally and disposed of by professional institutions to prevent pollution to the environment.