2-(2-Aminobenzoyl)pyridine

2- (2-aminobenzoyl) pyridine, its main uses are as follows:
This compound is widely used in the field of organic synthesis. In pharmaceutical chemistry, it is often used as a key intermediate. In the design and synthesis of many biologically active drug molecules, 2- (2-aminobenzoyl) pyridine can construct complex structures with specific pharmacological effects through ingenious chemical reactions. For example, when developing some antibacterial and anti-inflammatory drugs, with its unique molecular structure, it can precisely interact with the target biological target, thus exerting therapeutic effects.
In the field of materials science, it also has important uses. It can participate in the preparation of functional materials, such as organic optoelectronic materials. Due to its special electron cloud distribution and molecular configuration, it can endow materials with unique optical and electrical properties. For example, in the synthesis of organic Light Emitting Diode (OLED) materials, the introduction of this structure helps to adjust key parameters such as luminous efficiency and color purity of the material, thereby improving the performance of OLED devices.
In addition, in coordination chemistry, 2- (2-aminobenzoyl) pyridine can coordinate with a variety of metal ions by virtue of the nitrogen atoms on the amino group and pyridine ring, forming complexes with diverse structures. These complexes exhibit unique properties in the field of catalysis, and can be used as high-efficiency catalysts to accelerate many organic reactions and improve the yield and selectivity of the reaction. Overall, 2- (2-aminobenzoyl) pyridine plays an indispensable role in many important fields due to its unique structure.

2 - (2 -aminobenzoyl) derivatives have the following physical properties:
Their appearance often varies according to the specific structure, and they are mostly crystalline or powdery. In terms of color, some of them are white. If there are chromophores such as conjugated systems in the molecular structure, they may show different colors such as light yellow to dark yellow.
Melting point is one of the important physical properties, which varies due to differences in factors such as intermolecular forces and hydrogen bonds. Due to the presence of amino groups and benzoyl groups, hydrogen bonds can be formed between molecules, making the melting point relatively high. For example, some simple 2 - (2 - aminobenzoyl) compounds have melting points between 150 ° C and 200 ° C, depending on the type and location of the substituents on the benzene ring.
In terms of solubility, such compounds have various solubility in organic solvents. In view of the fact that there are both polar groups such as amino groups in their molecules and non-polar parts such as benzene rings, in polar organic solvents such as ethanol and acetone, they can form hydrogen bonds or dipole-dipole interactions with solvents, which have a certain solubility; in non-polar organic solvents such as n-hexane, the solubility is relatively small. < Br >
In terms of density, it is roughly consistent with the density range of common organic compounds, generally between 1.1 and 1.3 g/cm ³, which is closely related to its molecular composition and structure.
In addition, 2- (2-aminobenzoyl) derivatives also have a certain refractive index, which can reflect the compactness of their molecular structure and the distribution of electron clouds. Usually, the refractive index is around 1.5-1.6. The specific value is affected by factors such as the type of atoms in the molecule and the type of chemical bonds.

2-%282-%E6%B0%A8%E5%9F%BA%E8%8B%AF%E7%94%B2%E9%85%B0%E5%9F%BA%29%E5%90%A1%E5%95%B6%E7%9A%84%E5%8C%96%E5%AD%A6%E6%80%A7%E8%B4%A8%E5%B9%B6%E9%9D%9E%E5%8D%B3%E7%A8%B3%E5%AE%9A%E4%B9%8B%E7%89%A9. This is an organic chemical substance, and its chemical properties may vary depending on the environment and reaction conditions encountered.
Looking at this structure, (2-hydroxybenzyl) partially contains hydroxyl groups, and the hydroxyl groups have certain reactivity. The oxygen atom of the hydroxyl group has a solitary pair of electrons and can participate in many reactions, such as nucleophilic reactions. It can interact with electrophilic reagents. Due to the large electronegativity of oxygen, the electron cloud density is high, and it is easy to attract electron-deficient electrophilic reagents.
Furthermore, the conjugated system of the benzyl part and the benzene ring makes this structure stable to a certain extent, but it also gives it special reactivity. The benzene ring can undergo electrophilic substitution reaction, because its π electron cloud is exposed above and below the ring, and it is vulnerable to electrophilic attack.
When in a specific acid-base environment, the hydroxyl group can undergo protonation or deprotonation, which can significantly change its chemical properties and reactivity. In an alkaline environment, the hydroxyl group is prone to lose protons and form oxygen negative ions, which enhances its nucleophilicity and is more likely to participate in nucleophilic substitution and other reactions.
In addition, in case of oxidation reagents, the hydroxyl group may be oxidized, resulting in a major change in the structure and properties of this compound.
In conclusion, the chemical properties of 2 - (2 - hydroxybenzyl) are not absolutely stable, but are extremely sensitive to the chemical environment in which they are located, and can exhibit a variety of reactivity and chemical behavior under different conditions.

To prepare 2 - (2 - aminobenzyl) pyridine, there are many synthesis methods, which are described in detail as follows:
First, 2 - halopyridine and 2 - aminobenzyl halide are used as raw materials, under the action of bases, through nucleophilic substitution reaction. This reaction condition is mild and convenient to operate, so it is necessary to select suitable halogenates and bases to improve the reaction yield. If 2 - chloropyridine and 2 - aminobenzyl chloride are heated in a suitable organic solvent in the presence of potassium carbonate and other bases, after stirring, separation, purification and other steps, the target product can be obtained.
Second, the coupling reaction catalyzed by transition metals. The coupling reaction is carried out with 2-pyridyl boronic acid and 2-halobenzyl amine as raw materials under the action of transition metal catalysts such as palladium. This method has good selectivity and high yield, but the catalyst cost is high and the reaction conditions are strict. For example, in a nitrogen-protected atmosphere, palladium acetate is used as the catalyst and bipyridyl is used as the ligand, the two are reacted in an organic solvent under basic conditions, and then the product is obtained by separation and purification.
Third, 2-pyridyl formaldehyde and 2-aminobenzyl amine are used as the starting materials, and the imine intermediate is obtained first through condensation reaction, and then the target product is prepared by reduction reaction. The condensation reaction is usually carried out under acidic conditions, and reducing agents such as sodium borohydride can be selected for the reduction step. This approach is easy to obtain raw materials, and the steps are relatively simple. However, the reduction process requires attention to control the reaction conditions to prevent side reactions such as excessive reduction.
Fourth, through the cyclization reaction of pyridine derivatives and benzylamine derivatives. This method requires specific reaction conditions and catalysts, and can construct the structure of the target molecule in one step. It requires high requirements for reaction design. If the conditions are suitable, the product can be synthesized efficiently.
All these synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material availability, cost, reaction conditions and product purity requirements, and make careful choices.

2 - (2 -Aminobenzyl amino) What is the price of this product in the market?
In Guanfu's shops, the price of the product often depends on many reasons. First, the state of supply and demand is essential. If there are many buyers for this product in the market, and there are few suppliers, its price will rise; conversely, if the supply exceeds demand, the price may decline. Second, manufacturing costs are also key. Such as the price of raw materials, labor costs, equipment consumption, etc., will affect its final price. If the raw materials are rare and expensive, and the manufacturing labor costs are also high, the price will naturally be expensive. Third, the trend of competition in the same industry should not be underestimated. If there are many similar things in the market competing with each other, in order to attract customers to buy their own products, merchants may compete with each other on price, resulting in fluctuations in the price of this product.
However, I do not know the specific market details of "2- (2-Aminobenzyl Amino) ", such as its common uses, main production areas, mainstream manufacturers, etc. Without such information, it is difficult to say exactly what the price is. Or when you go to the market in person, consult the merchants, or check the relevant trade books and market reports, you can get a more accurate price. And the market is fickle, and the price will also move with the times, so you need to observe it in real time to know its current price.